scholarly journals DNA vaccines for cervical cancer: from bench to bedside

2007 ◽  
Vol 39 (6) ◽  
pp. 679-689 ◽  
Author(s):  
Chien-Fu Hung ◽  
Archana Monie ◽  
Ronald D Alvarez ◽  
T-C Wu
Keyword(s):  
Cervical Cancer ◽  
Dna Vaccines

scholarly journals A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine

2019 ◽  
Vol 22 ◽  
pp. 536-547 ◽  
Author(s):  
Mohammad Nasir Uddin ◽  
Brittany Henry ◽  
Kewan D Carter ◽  
Monzurul a Roni ◽  
Samir S Kouzi
Keyword(s):  
Cervical Cancer ◽  
Dosage Form ◽  
Dna Vaccines ◽  
Dosage Forms ◽  
Human Papillomaviruses ◽  
Cold Chain ◽  
Native Form ◽  
Dna Viruses ◽  
Virus Like Particle ◽  
Therapeutic Tools

Human papillomaviruses (HPV) are small, double-stranded DNA viruses that cause cervical cancer, the second most lethal cancer among women in the world. Currently, two vaccines are on the market for preventing HPV-caused cervical cancers and warts. Both are virus-like particle (VLP)-based vaccines. However, these vaccines have limitations; they are costly, have an invasive route of administration, require trained personnel to administer, need cold chain storage to preserve them, and most of all, they are preventive vaccines that do not have curative effects. Therefore, it is necessary to develop therapeutic HPV vaccines to facilitate the control of HPV-associated malignancies and to address all these issues. Recently there are DNA vaccines under investigation to prevent HPV. In general, DNA-based vaccines are better than or an excellent alternative to traditional vaccines since they can closely mimic live infections and can induce both antibody and cell-mediated immune responses. DNA vaccines involve the delivery of plasmid DNA (pDNA) which encodes the specific antigens. DNA vaccines have potential to be effective therapeutic tools against HPV infections. Combining the VLP-based and DNA-based vaccines can be highly effective as they can complement each other. VLP vaccines are more prone to mucosal immunity whereas DNA vaccines are more towards systemic immunity. In this article, we discuss an optimal formulation that will contain both type of vaccines, preventive and therapeutic. A film dosage form can be a good option which can be administered in buccal or sublingual routes for systemic action or in the vaginal area for local action to treat cervical cancer and to protect from future infection. Multiple vaccines in native form or in particulate form can be incorporated in film dosage forms. The film dosage form of vaccines can elicit both antibody-mediated (preventative) and cell-mediated (therapeutic) mechanisms. Film dosage forms are feasible to prepare for vaccine administration in the mouth cavity, GI tract, and vagina.

A combined ultrastructural and gene molecular research for the relationship between human uterine cervical carcinoma and human papillomavirus

1990 ◽  
Vol 48 (3) ◽  
pp. 204-205
Author(s):  
Kun Lee ◽  
Jingyi Si ◽  
Ricai Han ◽  
Wei Zhang ◽  
Bingbing Tan ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Intraepithelial Neoplasia ◽  
Hpv Infection ◽  
Dot Blot ◽  
Homologous Sequences ◽  
Normal Cervical Epithelium ◽  
The Relationship ◽  
Chronic Cervicitis

There are more supports for the view that human papillomavirus (HPV) infection might be an etiological factor in the development of cervical cancer when the association of persistent condylomata is considered. Biopsies from 318 cases with squamous cell carcinoma of uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 normal cervical epithelium were collected from 5 geographic regions of China with different cervical cancer mortalities. All specimens were prepared for Dot blot, Southern blot and in situ DNA-DNA hybridizations by using HPV-11, 16, 18 DNA labelled with 32P and 3H as probes to detect viral homologous sequences in samples. Among them, 32 cases with cervical cancer, 27 with condyloma and 10 normal cervical epitheliums were randomly chosen for comparative EM observation. The results showed that: 1), 192 out of 318 (60.4%) cases of cervical cancer were positive for HPV-16 DNA probe (Table I)

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

Stanniocalcin 1 enhanced sensitization of cervical cancer CaSki cells to anti-tumor drugs

2010 ◽  
Vol 34 (8) ◽  
pp. S49-S49
Author(s):  
Ya‑Lin Li ◽  
Feng‑Jie Guo ◽  
Jia‑Jia Wang ◽  
Yue‑Hui Li ◽  
Yan‑Hong Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Tumor Drugs

The effect of multidisciplinary team integration on treatment completion disparities in women undergoing treatment for cervical cancer

2020 ◽  
Vol 159 ◽  
pp. 179-180
Author(s):  
A.L. Beavis ◽  
A.F. Rositch ◽  
A. Romero-Sackey ◽  
A. Viswanathan ◽  
A.N. Fader ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Multidisciplinary Team ◽  
Treatment Completion ◽  
Team Integration

Low-income minority women at risk for cervical cancer: a process to improve adherence to follow-up recommendations

2001 ◽  
Vol 116 (6) ◽  
pp. 608-616 ◽  
Author(s):  
Virginia A Cardin ◽  
Richard M Grimes ◽  
Zhi Dong Jiang ◽  
Nancy Pomeroy ◽  
Luther Harrell ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
At Risk ◽  
Low Income ◽  
Minority Women

Subjective self-assessment of morbidity 8-25 months following radical hysterectomy for cervical cancer

1998 ◽  
Vol 5 (1) ◽  
pp. 79A-79A
Author(s):  
S BUTLERMANUEL ◽  
K SUMMERVILLE ◽  
A FORD ◽  
A RILEY ◽  
F CHAN ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Radical Hysterectomy ◽  
Self Assessment
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