scholarly journals zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells

2006 ◽  
Vol 38 (6) ◽  
pp. 634-642 ◽  
Author(s):  
Su-Bog Yee ◽  
Soo Jin Baek ◽  
Hwan Tae Park ◽  
Seung Hun Jeong ◽  
Jin Hee Jeong ◽  
...  
Keyword(s):  
Mastocytoma Cells ◽  
Caspase 6 ◽  
P815 Mastocytoma

scholarly journals Transmembrane signaling in P815 mastocytoma cells by transfected IgE receptors.

1990 ◽  
Vol 265 (21) ◽  
pp. 12444-12453 ◽  
Author(s):  
L Miller ◽  
G Alber ◽  
N Varin-Blank ◽  
R Ludowyke ◽  
H Metzger
Keyword(s):  
Transmembrane Signaling ◽  
Ige Receptors ◽  
Mastocytoma Cells ◽  
P815 Mastocytoma

Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells

2007 ◽  
Vol 31 (9) ◽  
pp. 979-984 ◽  
Author(s):  
E. Ümit Bağrıaçık ◽  
Kadriye Uslu ◽  
Erkan Yurtçu ◽  
Milan Stefek ◽  
Çimen Karasu
Keyword(s):  
Caspase 9 ◽  
Mastocytoma Cells ◽  
Induced Apoptosis ◽  
Dependent Pathway ◽  
P815 Mastocytoma

Synthetic chenodeoxycholic acid derivative HS-1200-induced apoptosis of p815 mastocytoma cells is augmented by co-treatment with lactacystin

2003 ◽  
Vol 14 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Su Yeong Seo ◽  
Eun Joo Jun ◽  
Sung Moon Jung ◽  
Ki-Ho Kim ◽  
Young Jin Lim ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Chenodeoxycholic Acid ◽  
Mastocytoma Cells ◽  
Induced Apoptosis ◽  
P815 Mastocytoma

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells

Nature ◽  
1984 ◽  
Vol 308 (5957) ◽  
pp. 367-370 ◽  
Author(s):  
M. M. Simon ◽  
H. U. Weltzien ◽  
H. J. Bühring ◽  
K. Eichmann
Keyword(s):  
T Cell ◽  
T Cell Clones ◽  
Cell Clones ◽  
Specific Cytotoxicity ◽  
Mastocytoma Cells ◽  
Killer T Cell ◽  
P815 Mastocytoma

scholarly journals On the heterogeneity of murine natural killer cells.

1981 ◽  
Vol 154 (3) ◽  
pp. 750-762 ◽  
Author(s):  
N Minato ◽  
L Reid ◽  
B R Bloom
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Measles Virus ◽  
Cell Subset ◽  
Regulatory Control ◽  
Target Cells ◽  
Nk Activity ◽  
Mastocytoma Cells ◽  
P815 Mastocytoma

The heterogeneity of cells capable exerting spontaneous cytotoxicity in vitro was explored using antisera to several genetically determined surface markers on mouse lymphocytes. Four phenotypes of cells derived either from fresh or cultured murine lymphoid tissue were found to exert natural killer (NK) activity in vitro. One affector cell subset, termed NKI cells, had the serological phenotype of Thy-1-, Lyt-2-, Qa5+, and lysed measles virus persistently infected target cells (HeLa-Ms) but not P815 mastocytoma cells. It corresponds with the NK cells described in most systems in which lymphoma targets are commonly used. A second subset, with the same target cell specificity, termed NKT is a thymus-independent cell with the phenotype Thy-1+, Lyt-2-, Qa-5+, Ly-5+. A third subset of NK cells, termed T killer (TK) cells deriving from cultures of conventional but not nude mouse spleens, mediated spontaneous cytotoxicity of P815 mastocytoma cells, but not of virus-infected targets. It has a phenotype of Thy-1+, Lyt-2+, Qa-5-, Ly-5+, apparently identical with that of conventional, antigen-specific cytotoxic T lymphocytes. The fourth phenotype of NK cells, termed NKM, derived primarily from cultures of bone marrow, is cytotoxic for HeLa-measles but not P815, and expresses only Ly-5+ among the various markers tested. Beige mice possess normal TK and NKM activities, but had normal NKI, NKT as well as NKM activity. All NK cell subsets express the Ly-5 surface marker. The existence of four phenotypically distinct NK effector cells was strengthened by studies on selective regulation of their activity by two different biological factors. Interferon (IFN) augmented NK activity of primarily one of the subsets examined, the NKI cell; the activity of IFN on NKT cells could not be directly tested, but IFN was without positive effect on TK or NKM cells. In contrast, partially purified IFN-free interleuken 2 (IL-2) augmented the activities of both the TK and NKT subsets, but not of NKI or NKM cell. IL-2 was active in augmenting NK activity in spleen cells obtained from both conventional and nu/nu mice, but was without effect on spleens of nu/nu mice depleted of Thy-1+ cells. These and other data suggest that IL-2 acts primarily, if not exclusively, on THy-1+ cells. These results strengthen the view that natural cytotoxicity in vitro can be mediated by several distinct cell populations under different genetic and regulatory control and indicate the importance of defining and delineating the cell lineages of each and the role of the independent subsets in resistance to virus infections and tumors in vivo.

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