scholarly journals Cell-type specific regulation of thrombospondin-1 expression and its promoter activity by regulatory agents

2001 ◽  
Vol 33 (3) ◽  
pp. 117-123 ◽  
Author(s):  
Soo-A Kim ◽  
Jong-Hoon Kang ◽  
Inho Cho ◽  
Sung-Won Bae ◽  
Kyong-Ja Hong
Keyword(s):  
Promoter Activity ◽  
Cell Type ◽  
Thrombospondin 1 ◽  
Cell Type Specific ◽  
Specific Regulation

scholarly journals Cell type specific regulation of COUP-TF II promoter activity

FEBS Letters ◽  
1996 ◽  
Vol 391 (1-2) ◽  
pp. 95-100 ◽  
Author(s):  
A. Soosaar ◽  
K. Neuman ◽  
H.O. Nornes ◽  
T. Neuman
Keyword(s):  
Promoter Activity ◽  
Cell Type ◽  
Cell Type Specific ◽  
Specific Regulation

scholarly journals Cell Type-Specific Regulation of CREB Gene Expression: Mutational Analysis of CREB Promoter Activity

2002 ◽  
Vol 71 (5) ◽  
pp. 1865-1874 ◽  
Author(s):  
Emily Coven ◽  
Yan Ni ◽  
Katherine L. Widnell ◽  
Jingshan Chen ◽  
William H. Walker ◽  
...  
Keyword(s):  
Gene Expression ◽  
Promoter Activity ◽  
Mutational Analysis ◽  
Cell Type ◽  
Cell Type Specific ◽  
Specific Regulation

scholarly journals Shisa6 mediates cell-type specific regulation of depression in the nucleus accumbens

2021 ◽  
Author(s):  
Hee-Dae Kim ◽  
Jing Wei ◽  
Tanessa Call ◽  
Nicole Teru Quintus ◽  
Alexander J. Summers ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
Current Treatment ◽  
Specific Cell ◽  
Excitatory Synapses ◽  
Cell Type ◽  
Cell Type Specific ◽  
Specific Regulation ◽  
Circuit Function

AbstractDepression is the leading cause of disability and produces enormous health and economic burdens. Current treatment approaches for depression are largely ineffective and leave more than 50% of patients symptomatic, mainly because of non-selective and broad action of antidepressants. Thus, there is an urgent need to design and develop novel therapeutics to treat depression. Given the heterogeneity and complexity of the brain, identification of molecular mechanisms within specific cell-types responsible for producing depression-like behaviors will advance development of therapies. In the reward circuitry, the nucleus accumbens (NAc) is a key brain region of depression pathophysiology, possibly based on differential activity of D1- or D2- medium spiny neurons (MSNs). Here we report a circuit- and cell-type specific molecular target for depression, Shisa6, recently defined as an AMPAR component, which is increased only in D1-MSNs in the NAc of susceptible mice. Using the Ribotag approach, we dissected the transcriptional profile of D1- and D2-MSNs by RNA sequencing following a mouse model of depression, chronic social defeat stress (CSDS). Bioinformatic analyses identified cell-type specific genes that may contribute to the pathogenesis of depression, including Shisa6. We found selective optogenetic activation of the ventral tegmental area (VTA) to NAc circuit increases Shisa6 expression in D1-MSNs. Shisa6 is specifically located in excitatory synapses of D1-MSNs and increases excitability of neurons, which promotes anxiety- and depression-like behaviors in mice. Cell-type and circuit-specific action of Shisa6, which directly modulates excitatory synapses that convey aversive information, identifies the protein as a potential rapid-antidepressant target for aberrant circuit function in depression.

The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation

1992 ◽  
Vol 12 (2) ◽  
pp. 552-562
Author(s):  
L Pani ◽  
X B Quian ◽  
D Clevidence ◽  
R H Costa
Keyword(s):  
Transcription Factor ◽  
Promoter Activity ◽  
Binding Activity ◽  
Specific Factor ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Cell Type Specific

The transcription factor hepatocyte nuclear factor 3 (HNF-3) is involved in the coordinate expression of several liver genes. HNF-3 DNA binding activity is composed of three different liver proteins which recognize the same DNA site. The HNF-3 proteins (designated alpha, beta, and gamma) possess homology in the DNA binding domain and in several additional regions. To understand the cell-type-specific expression of HNF-3 beta, we have defined the regulatory sequences that elicit hepatoma-specific expression. Promoter activity requires -134 bp of HNF-3 beta proximal sequences and binds four nuclear proteins, including two ubiquitous factors. One of these promoter sites interacts with a novel cell-specific factor, LF-H3 beta, whose binding activity correlates with the HNF-3 beta tissue expression pattern. Furthermore, there is a binding site for the HNF-3 protein within its own promoter, suggesting that an autoactivation mechanism is involved in the establishment of HNF-3 beta expression. We propose that both the LF-H3 beta and HNF-3 sites play an important role in the cell-type-specific expression of the HNF-3 beta transcription factor.

scholarly journals Cell-type-specific regulation of raft-associated Akt signaling

2011 ◽  
Vol 2 (4) ◽  
pp. e145-e145 ◽  
Author(s):  
Y Liu ◽  
G Yang ◽  
X Bu ◽  
G Liu ◽  
J Ding ◽  
...  
Keyword(s):  
Akt Signaling ◽  
Cell Type ◽  
Cell Type Specific ◽  
Specific Regulation

scholarly journals The 5′-flanking region of humanCD24 gene has cell-type-specific promoter activity in small-cell lung cancer

1998 ◽  
Vol 78 (4) ◽  
pp. 496-502 ◽  
Author(s):  
Maria K. Pass ◽  
Gianluca Quintini ◽  
Jürg A. Zarn ◽  
Sandra M. Zimmermann ◽  
Jürg A. Sigrist ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Promoter Activity ◽  
Small Cell ◽  
Cell Type ◽  
Small Cell Lung ◽  
Cell Type Specific ◽  
Flanking Region
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