scholarly journals Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells

1998 ◽  
Vol 30 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Jeongwon Sohn ◽  
Chul-Hee Lee ◽  
Dong Jun Chung ◽  
Sul Hee Park ◽  
Insun Kim ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Petroleum Ether ◽  
Renal Cell ◽  
Cell Cycle Progression ◽  
Petroleum Ether Extract ◽  
Carcinoma Cells ◽  
Ether Extract ◽  
Cycle Progression ◽  
Human Renal Cell Carcinoma

scholarly journals Molecular and Functional Analysis of Sunitinib-Resistance Induction in Human Renal Cell Carcinoma Cells

2021 ◽  
Vol 22 (12) ◽  
pp. 6467
Author(s):  
Magdalena Rausch ◽  
Adriano Rutz ◽  
Pierre-Marie Allard ◽  
Céline Delucinge-Vivier ◽  
Mylène Docquier ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Cycle Progression ◽  
Mass Spectrometry Analysis ◽  
Cycle Progression ◽  
Human Renal Cell Carcinoma ◽  
Resistance Induction ◽  
Extracellular Matrix Components

Resistance in clear cell renal cell carcinoma (ccRCC) against sunitinib is a multifaceted process encompassing numerous molecular aberrations. This induces clinical complications, reducing the treatment success. Understanding these aberrations helps us to select an adapted treatment strategy that surpasses resistance mechanisms, reverting the treatment insensitivity. In this regard, we investigated the dominant mechanisms of resistance to sunitinib and validated an optimized multidrug combination to overcome this resistance. Human ccRCC cells were exposed to single or chronic treatment with sunitinib to obtain three resistant clones. Upon manifestation of sunitinib resistance, morphometric changes in the cells were observed. At the molecular level, the production of cell membrane and extracellular matrix components, chemotaxis, and cell cycle progression were dysregulated. Molecules enforcing the cell cycle progression, i.e., cyclin A, B1, and E, were upregulated. Mass spectrometry analysis revealed the intra- and extracellular presence of N-desethyl sunitinib, the active metabolite. Lysosomal sequestration of sunitinib was confirmed. After treatment with a synergistic optimized drug combination, the cell metabolic activity in Caki-1-sunitinib-resistant cells and 3D heterotypic co-cultures was reduced by >80%, remaining inactive in non-cancerous cells. These results demonstrate geno- and phenotypic changes in response to sunitinib treatment upon resistance induction. Mimicking resistance in the laboratory served as a platform to study drug responses.

scholarly journals Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection

2015 ◽  
Vol 15 (6) ◽  
pp. 861-867 ◽  
Author(s):  
Eric J. Askeland ◽  
Vincent A. Chehval ◽  
Ryan W. Askeland ◽  
Placede G. Fosso ◽  
Zaina Sangale ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Cycle Progression ◽  
Clear Cell ◽  
Metastatic Progression ◽  
Cell Renal Cell Carcinoma ◽  
Cycle Progression

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 7539-7547 ◽  
Author(s):  
Yi-Hsien Hsieh ◽  
Chien-Hsing Lee ◽  
Hsiao-Yun Chen ◽  
Shu-Ching Hsieh ◽  
Chia-Liang Lin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Dna Damage ◽  
Cell Carcinoma ◽  
Cell Cycle Arrest ◽  
Renal Cell ◽  
Carcinoma Cells ◽  
Human Renal Cell Carcinoma ◽  
Cycle Arrest

The Cell Cycle Progression Score: Unclear Role in Renal Cell Carcinoma

2018 ◽  
Vol 74 (1) ◽  
pp. 128-129 ◽  
Author(s):  
Daiki Ueno ◽  
Garrett M. Dancik ◽  
Brian Shuch
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Cycle Progression ◽  
Cycle Progression

scholarly journals Tanshinone IIA arrests cell cycle and induces apoptosis in 786-O human renal cell carcinoma cells

2012 ◽  
Vol 3 (5) ◽  
pp. 1144-1148 ◽  
Author(s):  
XIANLI WEI ◽  
LUNBIN ZHOU ◽  
LIANGYONG HU ◽  
YAOXIONG HUANG
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carcinoma Cells ◽  
Tanshinone Iia ◽  
Human Renal Cell Carcinoma

scholarly journals ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (32) ◽  
pp. 51829-51839 ◽  
Author(s):  
Gaosi Xu ◽  
Xiongbing Lu ◽  
Tianlun Huang ◽  
Jie Fan
Keyword(s):  
Cell Cycle ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cell Cycle Progression ◽  
Cycle Progression
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