Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis

Sebastian E Carrasco; Youyun Yang; Bryan Troxell; Xiuli Yang; Utpal Pal; X Frank Yang

doi:10.1038/emi.2015.54

Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis

Emerging Microbes & Infections ◽

10.1038/emi.2015.54 ◽

2015 ◽

Vol 4 (1) ◽

pp. 1-8 ◽

Cited By ~ 15

Author(s):

Sebastian E Carrasco ◽

Youyun Yang ◽

Bryan Troxell ◽

Xiuli Yang ◽

Utpal Pal ◽

...

Keyword(s):

Borrelia Burgdorferi ◽

Lyme Borreliosis ◽

Elongation Factor ◽

Immunogenic Protein

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Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis

Infection Genetics and Evolution ◽

10.1016/j.meegid.2016.04.019 ◽

2016 ◽

Vol 42 ◽

pp. 66-76 ◽

Cited By ~ 35

Author(s):

E. Claudia Coipan ◽

Setareh Jahfari ◽

Manoj Fonville ◽

G. Anneke Oei ◽

Lodewijk Spanjaard ◽

...

Keyword(s):

Borrelia Burgdorferi ◽

Lyme Borreliosis ◽

Clinical Manifestations ◽

Borrelia Burgdorferi S.L ◽

Sequence Types

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Questionnaire Surveys of Cases of Tick Bite and Lyme Borreliosis in Hunters in Hokkaido with Reference to Detection of Anti-Borrelia burgdorferi Antibody.

Internal Medicine ◽

10.2169/internalmedicine.31.1163 ◽

1992 ◽

Vol 31 (10) ◽

pp. 1163-1168 ◽

Cited By ~ 6

Author(s):

Nobuhiko KUBO ◽

Yasutomo ARASHIMA ◽

Minori YOSHIDA ◽

Masato KAWABATA ◽

Susumu NISHINARITA ◽

...

Keyword(s):

Borrelia Burgdorferi ◽

Lyme Borreliosis ◽

Tick Bite ◽

Questionnaire Surveys

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Association of Borrelia afzelii with rodents in Europe

Parasitology ◽

10.1017/s0031182002002548 ◽

2003 ◽

Vol 126 (1) ◽

pp. 11-20 ◽

Cited By ~ 152

Author(s):

K. HANINCOVÁ ◽

S. M. SCHÄFER ◽

S. ETTI ◽

H.-S. SEWELL ◽

V. TARAGELOVÁ ◽

...

Keyword(s):

Borrelia Burgdorferi ◽

Lyme Borreliosis ◽

Tick Infestation ◽

Zoonotic Transmission ◽

Host Association ◽

Borrelia Afzelii ◽

Hard Ticks ◽

Bank Voles ◽

Endemic Focus ◽

Questing Ticks

Borrelia burgdorferi sensu lato (s.l.) is maintained in nature by complex zoonotic transmission cycles, involving a large variety of vertebrates as hosts and hard ticks of the genus Ixodes as vectors. Recent studies suggest that the genospecies of B. burgdorferi s.l. and sometimes their subtypes are propagated by different spectra of hosts, mainly birds and rodents. In order to test the concept of host-association, we analysed the relationships between Borrelia genospecies, rodent hosts and I. ricinus ticks in an endemic focus of Lyme borreliosis in western Slovakia. Rodents and questing ticks were collected at a forested lowland locality near Bratislava. Tick infestation levels on rodents were determined, and spirochaete infections in ticks and in ear punch biopsies were analysed by PCR followed by genotyping. Mice were more heavily infested with ticks than bank voles, and a higher proportion of mice was infected with spirochaetes than voles. However, the infectivity of voles was much higher than that of mice. The vast majority of infections detected in the skin and in ticks feeding on the rodents represented B. afzelii. In contrast, more than half of all infections in questing ticks collected in the same region of Slovakia were identified as B. valaisiana and B. garinii. In conclusion, whilst the study reveals that mice and voles play different quantitative roles in the ecology of Lyme borreliosis, it demonstrates that B. afzelii is specifically maintained by European rodents, validating the concept of host-association of B. burgdorferi s.l.

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