scholarly journals Molecular evidence for interspecies transmission of H3N2pM/H3N2v influenza A viruses at an Ohio agricultural fair, July 2012

2012 ◽  
Vol 1 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Andrew S Bowman ◽  
Srinand Sreevatsan ◽  
Mary L Killian ◽  
Shannon L Page ◽  
Sarah W Nelson ◽  
...  
Keyword(s):  
Influenza A ◽  
Interspecies Transmission ◽  
Molecular Evidence ◽  
Influenza A Viruses

scholarly journals Molecular Evidence of Influenza A Virus Circulation in African Dromedary Camels Imported to Saudi Arabia, 2017–2018

2019 ◽  
Vol 6 (10) ◽  
Author(s):  
Abdulaziz Alghamdi ◽  
Ahmed M Hassan ◽  
Ahmed M Tolah ◽  
Sawsan S Alamari ◽  
Abdulrahman A Alzahrani ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Influenza A ◽  
Swine Influenza ◽  
Interspecies Transmission ◽  
Molecular Evidence ◽  
Influenza A Viruses ◽  
Influenza A H1n1 ◽  
Nasal Swabs ◽  
Close Relationship ◽  
Partial Genome

Abstract Little is known about influenza A viruses in dromedaries. Here, we detected influenza A viral RNA in 11 specimens (1.7 %) out of 665 nasal swabs collected from dromedaries between 2017 and 2018 in Saudi Arabia. Positive samples were detected only in imported camels from Sudan and Djibouti but not local ones. Partial genome sequencing indicates a close relationship to 2009–2019 human/swine influenza A H1N1 isolates from different countries, suggesting possible interspecies transmission. Taken together, dromedaries could represent a potentially unrecognized permissive host for these viruses, highlighting the need for enhanced surveillance in animals to aid implementation of one-health strategies.

Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review

EcoHealth ◽  
2015 ◽  
Vol 13 (1) ◽  
pp. 171-198 ◽  
Author(s):  
Olga Munoz ◽  
◽  
Marco De Nardi ◽  
Karen van der Meulen ◽  
Kristien van Reeth ◽  
...  
Keyword(s):  
Literature Review ◽  
Influenza A ◽  
Potential Role ◽  
Domestic Animals ◽  
Interspecies Transmission ◽  
Genetic Adaptation ◽  
Influenza A Viruses

Interspecies Transmission and Reassortment of Influenza A Viruses in Pigs and Turkeys in the United States

1992 ◽  
Vol 136 (4) ◽  
pp. 488-497 ◽  
Author(s):  
Stephen M. Wright ◽  
Yoshihiro Kawaoka ◽  
Gerold B. Sharp ◽  
Dennis A. Senne ◽  
Robert G. Webster
Keyword(s):  
United States ◽  
Influenza A ◽  
The United States ◽  
Interspecies Transmission ◽  
Influenza A Viruses

scholarly journals Erratum to: Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review

EcoHealth ◽  
2015 ◽  
Vol 13 (1) ◽  
pp. 199-199 ◽  
Author(s):  
Olga Munoz ◽  
◽  
Marco De Nardi ◽  
Karen van der Meulen ◽  
Kristien van Reeth ◽  
...  
Keyword(s):  
Literature Review ◽  
Influenza A ◽  
Potential Role ◽  
Domestic Animals ◽  
Interspecies Transmission ◽  
Genetic Adaptation ◽  
Influenza A Viruses

scholarly journals The host factor ANP32A is required for influenza A virus vRNA and cRNA synthesis

2021 ◽  
Author(s):  
Benjamin E Nilsson-Payant ◽  
Benjamin R. tenOever ◽  
Aartjan J.W. te Velthuis
Keyword(s):  
Rna Polymerase ◽  
Viral Replication ◽  
Influenza A Virus ◽  
Influenza A ◽  
Host Factor ◽  
Viral Rna ◽  
Molecular Evidence ◽  
Influenza A Viruses ◽  
Ribonucleoprotein Complexes ◽  
Rna Genome

Influenza A viruses are negative-sense RNA viruses that rely on their own viral replication machinery to replicate and transcribe their segmented single-stranded RNA genome. The viral ribonucleoprotein complexes in which viral RNA is replicated consist of a nucleoprotein scaffold around which the RNA genome is bound, and a heterotrimeric RNA-dependent RNA polymerase that catalyzes viral replication. The RNA polymerase copies the viral RNA (vRNA) via a replicative intermediate, called the complementary RNA (cRNA), and subsequently uses this cRNA to make more vRNA copies. To ensure that new cRNA and vRNA molecules are associated with ribonucleoproteins in which they can be amplified, the active RNA polymerase recruits a second polymerase to encapsidate the cRNA or vRNA. Host factor ANP32A has been shown to be essential for viral replication and to facilitate the formation of a dimer between viral RNA polymerases and differences between mammalian and avian ANP32A proteins are sufficient to restrict viral replication. It has been proposed that ANP32A is only required for the synthesis of vRNA molecules from a cRNA, but not vice versa. However, this view does not match recent molecular evidence. Here we use minigenome assays, virus infections, and viral promoter mutations to demonstrate that ANP32A is essential for both vRNA and cRNA synthesis. Moreover, we show that ANP32 is not only needed for the actively replicating polymerase, but also for the polymerase that is encapsidating nascent viral RNA products. Overall, these results provide new insights into influenza A virus replication and host adaptation.

scholarly journals Airborne Transmission of Avian Origin H9N2 Influenza A Viruses

2021 ◽  
Author(s):  
C. Joaquín Cáceres ◽  
Daniela S. Rajao ◽  
Daniel R. Perez
Keyword(s):  
Influenza A ◽  
Mammalian Species ◽  
World Health ◽  
Interspecies Transmission ◽  
Influenza A Viruses ◽  
Highly Pathogenic ◽  
Zoonotic Infections ◽  
The World ◽  
Avian Origin ◽  
Health Organization

Influenza A viruses (IAV) are widespread viruses affecting avian and mammalian species worldwide. Outbreaks of IAV in poultry are usually associated with substantial morbidity and mortality, significantly affecting the poultry industry and food security. IAVs from avian species can be transmitted to mammals including humans and, thus, they are of inherent pandemic concern. Most of the efforts to understand the pathogenicity and transmission of avian origin IAVs have been focused on H5 and H7 subtypes due to their highly pathogenic phenotype in poultry. However, IAV of the H9 subtype that circulate endemically in poultry flocks in some regions of the world have also been associated with cases of zoonotic infections. As a result, the World Health Organization includes avian origin H9N2 IAV among the top in the list of IAVs of pandemic concern. In this review, we discuss the interspecies transmission of H9N2 between avian and mammalian species and the molecular factors that are thought relevant for this spillover. Additionally, we discuss factors that have been associated with the ability of these viruses to transmit through the respiratory route in mammalian species.

Evidence for Interspecies Transmission and Reassortment of Influenza A Viruses in Pigs in Southern China

Virology ◽  
1994 ◽  
Vol 202 (2) ◽  
pp. 825-833 ◽  
Author(s):  
Li L. Shu ◽  
Yi P. Lin ◽  
Stephen M. Wright ◽  
Kennedy F. Shortridge ◽  
Robert G. Webster
Keyword(s):  
Influenza A ◽  
Southern China ◽  
Interspecies Transmission ◽  
Influenza A Viruses

scholarly journals Live Animal Markets in Minnesota: A Potential Source for Emergence of Novel Influenza A Viruses and Interspecies Transmission

2015 ◽  
Vol 61 (9) ◽  
pp. 1355-1362 ◽  
Author(s):  
Mary J. Choi ◽  
Montserrat Torremorell ◽  
Jeff B. Bender ◽  
Kirk Smith ◽  
David Boxrud ◽  
...  
Keyword(s):  
Influenza A ◽  
Interspecies Transmission ◽  
Influenza A Viruses ◽  
Live Animal ◽  
Potential Source ◽  
Novel Influenza A
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