scholarly journals Drosophila syndecan regulates tracheal cell migration by stabilizing Robo levels

EMBO Reports ◽  
2011 ◽  
Vol 12 (10) ◽  
pp. 1039-1046 ◽  
Author(s):  
Joachim G Schulz ◽  
Helga Ceulemans ◽  
Emmanuel Caussinus ◽  
Maria F Baietti ◽  
Markus Affolter ◽  
...  
Keyword(s):  
Cell Migration ◽  
Tracheal Cell

scholarly journals Hedgehog Is a Positive Regulator of FGF Signalling during Embryonic Tracheal Cell Migration

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92682 ◽  
Author(s):  
Elisenda Butí ◽  
Duarte Mesquita ◽  
Sofia J. Araújo
Keyword(s):  
Cell Migration ◽  
Positive Regulator ◽  
Tracheal Cell ◽  
Fgf Signalling

ventral veinless, a POU domain transcription factor, regulates different transduction pathways required for tracheal branching in Drosophila

Development ◽  
1997 ◽  
Vol 124 (17) ◽  
pp. 3273-3281 ◽  
Author(s):  
M. Llimargas ◽  
J. Casanova
Keyword(s):  
Cell Migration ◽  
Target Genes ◽  
Branching Pattern ◽  
Specific Expression ◽  
Tracheal System ◽  
Tracheal Cell ◽  
Pou Domain ◽  
Tracheal Branching ◽  
Multicellular Organisms

Cell migration is an important step in a variety of developmental processes in many multicellular organisms. A particularly appropriate model to address the study of cell migration is the tracheal system of Drosophila, whose formation occurs by migration and fusion from clusters of ectodermal cells specified in each side of ten embryonic segments. Morphogenesis of the tracheal tree requires the activity of many genes, among them breathless (btl) and ventral veinless (vvl) whose mutations abolish tracheal cell migration. Activation of the btl receptor by branchless (bnl), its putative ligand, exerts an instructive role in the process of guiding tracheal cell migration. vvl has been shown to be required for the maintenance of btl expression during tracheal tree formation. Here we show that, in addition, vvl is independently required for the specific expression in the tracheal cells of thick veins (tkv) and rhomboid (rho), two genes whose mutations disrupt only particular branches of the tracheal system. Indeed, we show that expression in the tracheal cells of an activated form of tkv, the putative decapentaplegic (dpp) receptor, is able to induce shifts in their migration, asserting the role of the dpp pathway in establishing the branching pattern of the tracheal tree. In addition, by ubiquitous expression of the btl and tkv genes in vvl mutant embryos we show that both genes contribute to vvl function. These results indicate that through activation of its target genes, vvl makes the tracheal cells competent to further signalling and suggest that the btl transduction pathway could collaborate with other transduction pathways also regulated by vvl to specify the tracheal branching pattern.

Hedgehog signaling patterns the tracheal branches

Development ◽  
2001 ◽  
Vol 128 (9) ◽  
pp. 1599-1606 ◽  
Author(s):  
L. Glazer ◽  
B.Z. Shilo
Keyword(s):  
Cell Migration ◽  
Hedgehog Signaling ◽  
Egf Receptor ◽  
Cell Types ◽  
Fixed Number ◽  
Branching Pattern ◽  
Tracheal System ◽  
Tracheal Cell ◽  
Distinct Cell

The elaborate branching pattern of the Drosophila tracheal system originates from ten tracheal placodes on both sides of the embryo, each consisting of about 80 cells. Simultaneous cell migration from each tracheal pit in six different directions gives rise to the stereotyped branching pattern. Each branch contains a fixed number of cells. Previous work has shown that in the dorsoventral axis, localized activation of the Dpp, Wnt and EGF receptor (DER) pathways, subdivides the tracheal pit into distinct domains. We present the role of the Hedgehog (Hh) signaling system in patterning the tracheal branches. Hh is expressed in segmental stripes abutting the anterior border of the tracheal placodes. Induction of patched expression, which results from activation by Hh, demonstrates that cells in the anterior half of the tracheal pit are activated. In hh-mutant embryos migration of all tracheal branches is absent or stalled. These defects arise from a direct effect of Hh on tracheal cells, rather than by indirect effects on patterning of the ectoderm. Tracheal cell migration could be rescued by expressing Hh only in the tracheal cells, without rescuing the ectodermal defects. Signaling by several pathways, including the Hh pathway, thus serves to subdivide the uniform population of tracheal cells into distinct cell types that will subsequently be recruited into the different branches.

scholarly journals A Genetic Mosaic Analysis With a Repressible Cell Marker Screen to Identify Genes Involved in Tracheal Cell Migration During Drosophila Air Sac Morphogenesis

Genetics ◽  
2007 ◽  
Vol 176 (4) ◽  
pp. 2177-2187 ◽  
Author(s):  
Hélène Chanut-Delalande ◽  
Alain C. Jung ◽  
Li Lin ◽  
Magdalena M. Baer ◽  
Andreas Bilstein ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Marker ◽  
Tracheal Cell ◽  
Genetic Mosaic ◽  
Mosaic Analysis

scholarly journals Dual function of the region-specific homeotic gene spalt during Drosophila tracheal system development

Development ◽  
1996 ◽  
Vol 122 (7) ◽  
pp. 2215-2223 ◽  
Author(s):  
R.P. Kuhnlein ◽  
R. Schuh
Keyword(s):  
Cell Migration ◽  
System Development ◽  
Dual Function ◽  
Homeotic Gene ◽  
Tracheal System ◽  
Directed Migration ◽  
Tracheal Cell ◽  
Distinct Subset ◽  
Directed Cell Migration ◽  
Placode Formation

We report that the region-specific homeotic gene spalt affects the Drosophila tracheal system at two different stages of embryonic development. Both lack-of-function and gain-of-function experiments show that blastodermal spalt activity restricts tracheal development to 10 bilaterally positioned pairs of tracheal placodes in the trunk region by repressing placode formation in parasegments 2, 3 and 14. The results suggest that the activity of the zinc-finger type transcription factor encoded by spalt suppresses the molecular pathway that establishes tracheal development. spalt function is also necessary for the directed migration of the dorsal trunk cells, a distinct subset of tracheal cells. This process is a prerequisite for the formation of the dorsal trunk generated by fusion of adjacent tracheal metameres into a common tubular structure. The directed cell migration, in which spalt gene function participates, seems to be independent of branch fusion and general tracheal cell migration processes.

scholarly journals DPP controls tracheal cell migration along the dorsoventral body axis of the Drosophila embryo

Development ◽  
1997 ◽  
Vol 124 (14) ◽  
pp. 2741-2750 ◽  
Author(s):  
S. Vincent ◽  
E. Ruberte ◽  
N.C. Grieder ◽  
C.K. Chen ◽  
T. Haerry ◽  
...  
Keyword(s):  
Cell Migration ◽  
Expression Patterns ◽  
Drosophila Embryo ◽  
Type I ◽  
Migration Behavior ◽  
Specific Expression ◽  
Drosophila Embryogenesis ◽  
Tracheal Cell ◽  
Guidance Molecule ◽  
To Receive

We report that DPP signaling is required for directed tracheal cell migration during Drosophila embryogenesis. The failure of tracheal cells to receive the DPP signal from adjacent dorsal and ventral cells results in the absence of dorsal and ventral migrations. Ectopic DPP signaling can reprogram cells in the center of the placode to adopt a dorsoventral migration behavior. The effects observed in response to ectopic DPP signaling are also observed upon the tracheal-specific expression of a constitutive active DPP type I receptor (TKV(Q253D)), indicating that the DPP signal is received and transmitted in tracheal cells to control their migration behavior. DPP signaling determines localized gene expression patterns in the developing tracheal placode, and is also required for the dorsal expression of the recently identified BRANCHLESS (BNL) guidance molecule, the ligand of the BREATHLESS (BTL) receptor. Thus, DPP plays a dual role during tracheal cell migration. It is required to control the dorsal expression of the BNL ligand; in addition, the DPP signal recruits groups of dorsal and ventral tracheal cells and programs them to migrate in dorsal and ventral directions.

scholarly journals Elucidation of the role of breathless, a Drosophila FGF receptor homolog, in tracheal cell migration.

1994 ◽  
Vol 8 (4) ◽  
pp. 428-439 ◽  
Author(s):  
M Reichman-Fried ◽  
B Dickson ◽  
E Hafen ◽  
B Z Shilo
Keyword(s):  
Cell Migration ◽  
Fgf Receptor ◽  
Tracheal Cell

scholarly journals branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching

Cell ◽  
1996 ◽  
Vol 87 (6) ◽  
pp. 1091-1101 ◽  
Author(s):  
David Sutherland ◽  
Christos Samakovlis ◽  
Mark A Krasnow
Keyword(s):  
Cell Migration ◽  
Tracheal Cell

scholarly journals Stripe Provides Cues Synergizing with Branchless to Direct Tracheal Cell Migration

2002 ◽  
Vol 252 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Ruslan Dorfman ◽  
Ben-Zion Shilo ◽  
Talila Volk
Keyword(s):  
Cell Migration ◽  
Tracheal Cell
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