scholarly journals Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

EMBO Reports ◽  
2008 ◽  
Vol 9 (6) ◽  
pp. 536-542 ◽  
Author(s):  
Fumiyo Ikeda ◽  
Ivan Dikic
Keyword(s):  
Protein Modifications ◽  
Molecular Signals

Sortase A Mediated Protein Modifications and Peptide Conjugations

2016 ◽  
Vol 12 (4) ◽  
pp. 205-213 ◽  
Author(s):  
Natalya Voloshchuk ◽  
Danni Liang ◽  
Jun Liang
Keyword(s):  
Sortase A ◽  
Protein Modifications

scholarly journals Protein Modifications by Activated Carcinogens

1973 ◽  
Vol 248 (8) ◽  
pp. 2730-2737
Author(s):  
Eugene J. Barry ◽  
Helmut R. Gutmann
Keyword(s):  
Protein Modifications

scholarly journals Glycans in autophagy, endocytosis and lysosomal functions

2021 ◽  
Author(s):  
Fulvio Reggiori ◽  
Hans-Joachim Gabius ◽  
Massimo Aureli ◽  
Winfried Römer ◽  
Sandro Sonnino ◽  
...  
Keyword(s):  
Sugar Code ◽  
Endogenous Lectins ◽  
Biological Aspects ◽  
Molecular Signals ◽  
Lysosomal Proteins ◽  
In Cells

AbstractGlycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

Proteomics and posttranslational protein modifications in Toxoplasma gondii

2020 ◽  
pp. 983-1020
Author(s):  
Louis M. Weiss ◽  
Jonathan Wastling ◽  
Victoria Jeffers ◽  
William J. Sullivan ◽  
Kami Kim
Keyword(s):  
Toxoplasma Gondii ◽  
Protein Modifications

scholarly journals A halotyrosine antibody that detects increased protein modifications in asthma patients

2014 ◽  
Vol 403 (1-2) ◽  
pp. 17-25 ◽  
Author(s):  
Hongjun Jin ◽  
Teal S. Hallstrand ◽  
Don S. Daly ◽  
Melissa M. Matzke ◽  
Parameswaran Nair ◽  
...  
Keyword(s):  
Protein Modifications ◽  
Asthma Patients

scholarly journals Isovitexin modulates autophagy in Alzheimer’s disease via miR-107 signalling

2020 ◽  
Vol 11 (1) ◽  
pp. 391-401
Author(s):  
Jiang Cheng ◽  
Guowei Wang ◽  
Na Zhang ◽  
Fang Li ◽  
Lina Shi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Loss ◽  
The Elderly ◽  
Tnf Α ◽  
Autophagic Process ◽  
Molecular Signals ◽  
Ad Mouse Model ◽  
Mtor Signalling

AbstractBackground:Alzheimer’s disease (AD) is an ultimately fatal, degenerative brain disease in the elderly people. In the current work, we assessed the defensive capability of isovitexin (IVX) through an intracerebroventricular injection of streptozotocin (STZ)-induced AD mouse model.Methods:Mice were separated into four cohorts: sham-operated control mice; STZ-intoxicated Alzheimer’s mice; IVX cohort, IVX + STZ; and Ant-107 cohort, antagomiR-107 + IVX/STZ as in the IVX cohort.Results:The outcomes indicated that IVX administration ameliorated spatial memory loss and blunted a cascade of neuro-noxious episodes – including increased amyloid-beta (Aβ) and degraded myelin basic protein burden, neuroinflammation (represented by elevated caspase-1, TNF-α and IL-6 levels) and autophagic dysfunction (represented by altered LC3-II, Atg7 and beclin-1 expressions) – via the inhibition of PI3K/Akt/mTOR signalling axis. We considered the question of whether the epigenetic role of microRNA-107 (miR-107) has any impact on these events, by using antagomiR-107.Conclusion:This probing underscored that miR-107 could be a pivotal regulatory button in the activation of molecular signals linked with the beneficial autophagic process and anti-inflammatory activities in relation to IVX treatment. Hence, this report exemplifies that IVX could guard against Aβ toxicity and serve as an effectual treatment for patients afflicted with AD.

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