scholarly journals Ribosome hijacking: a role for small protein B during trans ‐translation

EMBO Reports ◽  
2009 ◽  
Vol 10 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Sylvie Nonin‐Lecomte ◽  
Noella Germain‐Amiot ◽  
Reynald Gillet ◽  
Marc Hallier ◽  
Luc Ponchon ◽  
...  
Keyword(s):  
Small Protein ◽  
Small Protein B ◽  
Protein B

scholarly journals How a circularized tmRNA moves through the ribosome

Science ◽  
2019 ◽  
Vol 363 (6428) ◽  
pp. 740-744 ◽  
Author(s):  
Christopher D. Rae ◽  
Yuliya Gordiyenko ◽  
V. Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Messenger Rna ◽  
Small Protein ◽  
Reading Frame ◽  
Nascent Polypeptide ◽  
Cryo Electron Microscopy ◽  
Small Protein B ◽  
Protein B

During trans-translation, transfer-messenger RNA (tmRNA) and small protein B (SmpB) together rescue ribosomes stalled on a truncated mRNA and tag the nascent polypeptide for degradation. We used cryo–electron microscopy to determine the structures of three key states of the tmRNA-SmpB-ribosome complex during trans translation at resolutions of 3.7 to 4.4 angstroms. The results show how tmRNA and SmpB act specifically on stalled ribosomes and how the circularized complex moves through the ribosome, enabling translation to switch from the old defective message to the reading frame on tmRNA.

scholarly journals Pre-binding of Small Protein B to a Stalled Ribosome Triggerstrans-Translation

2004 ◽  
Vol 279 (25) ◽  
pp. 25978-25985 ◽  
Author(s):  
Marc Hallier ◽  
Natalia Ivanova ◽  
Armelle Rametti ◽  
Michael Pavlov ◽  
Måns Ehrenberg ◽  
...  
Keyword(s):  
Small Protein ◽  
Small Protein B ◽  
Protein B

scholarly journals A previously uncharacterized role for small protein B (SmpB) in transfer messenger RNA-mediated trans-translation

2005 ◽  
Vol 102 (7) ◽  
pp. 2316-2321 ◽  
Author(s):  
T. R. Sundermeier ◽  
D. P. Dulebohn ◽  
H. J. Cho ◽  
A. W. Karzai
Keyword(s):  
Messenger Rna ◽  
Small Protein ◽  
Small Protein B ◽  
Protein B

scholarly journals The highest affinity binding site of small protein B on transfer messenger RNA is outside the tRNA domain

RNA ◽  
2008 ◽  
Vol 14 (9) ◽  
pp. 1761-1772 ◽  
Author(s):  
L. Metzinger ◽  
M. Hallier ◽  
B. Felden
Keyword(s):  
Binding Site ◽  
Messenger Rna ◽  
Affinity Binding ◽  
Small Protein ◽  
Small Protein B ◽  
Protein B
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