scholarly journals Claudin-14 regulates renal Ca++transport in response to CaSR signalling via a novel microRNA pathway

2012 ◽  
Vol 31 (8) ◽  
pp. 1999-2012 ◽  
Author(s):  
Yongfeng Gong ◽  
Vijayaram Renigunta ◽  
Nina Himmerkus ◽  
Jiaqi Zhang ◽  
Aparna Renigunta ◽  
...  
Keyword(s):  
Ca Transport ◽  
Microrna Pathway ◽  
Claudin 14

scholarly journals Heme oxygenase-1 retards hepatocellular carcinoma progression through the microRNA pathway

2016 ◽  
Vol 36 (5) ◽  
pp. 2715-2722 ◽  
Author(s):  
Chaoxia Zou ◽  
Chendan Zou ◽  
Wanpeng Cheng ◽  
Qiang Li ◽  
Zhongjing Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Microrna Pathway

Localization of diuretic action in microperfused rat distal tubules: Ca and Na transport

1985 ◽  
Vol 248 (4) ◽  
pp. F527-F535 ◽  
Author(s):  
L. S. Costanzo
Keyword(s):  
Distal Tubule ◽  
Maximal Concentration ◽  
Na Transport ◽  
Tubule Cell ◽  
Ca Transport ◽  
Site Of Action ◽  
Distal Tubules ◽  
Sites Of Action ◽  
Distal Site

Experiments were performed in rats to examine the distal site of action of thiazide diuretics and the additive hypocalciuric properties of thiazides and amiloride. In clearance experiments, the maximal natriuretic and hypocalciuric dose of chlorothiazide was established. When amiloride was added, there was further augmentation of Ca reabsorption (P less than 0.025) but no additional natriuresis. Amiloride blunted thiazide-induced kaliuresis (P less than 0.001). Localization of the thiazide effect was studied in early and late distal tubules microperfused in vivo with control and thiazide-containing solutions. The maximally effective luminal drug concentration, 5 X 10(-4) M, inhibited Na transport (P less than 0.001) and enhanced Ca transport (P less than 0.01) in the early distal segments; late segments were on the average unaffected. It is suggested that thiazides interact with the distal convoluted tubule cell, whose predominant location is the early distal tubule. In two long distal tubules, with early and late segments, a maximal concentration of chlorothiazide increased Ca transport and decreased Na transport. Addition of 10(-5) M amiloride caused an additional increment in Ca reabsorption. As amiloride's action is located in the late distal tubule, it is suggested from these experiments that a basis for additive hypocalciuric actions of thiazides and amiloride is separate sites of action in the distal tubule.

scholarly journals Author Correction: nc886 is induced by TGF-β and suppresses the microRNA pathway in ovarian cancer

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Ji-Hye Ahn ◽  
Hyun-Sung Lee ◽  
Ju-Seog Lee ◽  
Yeon-Su Lee ◽  
Jong-Lyul Park ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Microrna Pathway

A variant in a cis -regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones

2017 ◽  
Vol 38 (6) ◽  
pp. 649-657 ◽  
Author(s):  
Megan E. Ure ◽  
Emma Heydari ◽  
Wanling Pan ◽  
Ajay Ramesh ◽  
Sabah Rehman ◽  
...  
Keyword(s):  
Kidney Stones ◽  
Regulatory Element ◽  
Pediatric Onset ◽  
Claudin 14

scholarly journals Role of microRNA Pathway in Mental Retardation

2007 ◽  
Vol 7 ◽  
pp. 146-154 ◽  
Author(s):  
Abrar Qurashi ◽  
Shuang Chang ◽  
Peng Jin
Keyword(s):  
Mental Retardation ◽  
Fragile X Syndrome ◽  
Genetic Basis ◽  
Fragile X ◽  
Biological Pathways ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein ◽  
Mirna Pathway ◽  
Microrna Pathway

Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR. Fragile X syndrome is one of the most common forms of inherited MR, caused by the loss of functional Fragile X Mental Retardation Protein (FMRP).MicroRNAs (miRNAs) are endogenous, single-stranded RNAs between 18 and 25 nucleotides in length, which have been implicated in diversified biological pathways. Recent studies have linked the miRNA pathway to fragile X syndrome. Here we review the role of the miRNA pathway in fragile X syndrome and discuss its implication in MR in general.

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