scholarly journals The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria

2012 ◽  
Vol 31 (16) ◽  
pp. 3507-3507 ◽  
Author(s):  
Anastasia A Aksyuk ◽  
Petr G Leiman ◽  
Lidia P Kurochkina ◽  
Mikhail M Shneider ◽  
Victor A Kostyuchenko ◽  
...  
Keyword(s):  
Bacteriophage T4 ◽  
Molecular Machine ◽  
Tail Sheath ◽  
Sheath Structure

scholarly journals The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria

2009 ◽  
Vol 28 (7) ◽  
pp. 821-829 ◽  
Author(s):  
Anastasia A Aksyuk ◽  
Petr G Leiman ◽  
Lidia P Kurochkina ◽  
Mikhail M Shneider ◽  
Victor A Kostyuchenko ◽  
...  
Keyword(s):  
Bacteriophage T4 ◽  
Molecular Machine ◽  
Tail Sheath ◽  
Sheath Structure

Polymerization of Bacteriophage T4 Tail Sheath Protein Mutants Truncated at the C-Termini

1999 ◽  
Vol 127 (3) ◽  
pp. 224-230 ◽  
Author(s):  
Boris F. Poglazov ◽  
Andrei V. Efimov ◽  
Sergio Marco ◽  
Jose Carrascosa ◽  
Tanya A. Kuznetsova ◽  
...  
Keyword(s):  
Bacteriophage T4 ◽  
Protein Mutants ◽  
Tail Sheath

scholarly journals A First Model of the Dynamics of the Bacteriophage T4 Injection Machinery

2016 ◽  
Vol 11 (4) ◽  
Author(s):  
Ameneh Maghsoodi ◽  
Anupam Chatterjee ◽  
Ioan Andricioaei ◽  
N. C. Perkins
Keyword(s):  
Bacteriophage T4 ◽  
Infection Process ◽  
Hydrodynamic Drag ◽  
Kirchhoff Rod ◽  
Rod Theory ◽  
Tail Assembly ◽  
Contractile Tail ◽  
Helical Protein ◽  
Important Building Block ◽  
Sheath Structure

Bacteriophage T4 is one of the most common and complex of the tailed viruses that infect host bacteria using an intriguing contractile tail assembly. Despite extensive progress in resolving the structure of T4, the dynamics of the injection machinery remains largely unknown. This paper contributes a first model of the injection machinery that is driven by elastic energy stored in a structure known as the sheath. The sheath is composed of helical strands of protein that suddenly collapse from an energetic, extended conformation prior to infection to a relaxed, contracted conformation during infection. We employ Kirchhoff rod theory to simulate the nonlinear dynamics of a single protein strand coupled to a model for the remainder of the virus, including the coupled translation and rotation of the head (capsid), neck, and tail tube. Doing so provides an important building block toward the future goal of modeling the entire sheath structure which is composed of six interacting helical protein strands. The resulting numerical model exposes fundamental features of the injection machinery including the time scale and energetics of the infection process, the nonlinear conformational change experienced by the sheath, and the contribution of hydrodynamic drag on the head (capsid).

The Tail Sheath of Bacteriophage T4 as a Microactuator

2006 ◽  
Vol 342 (1) ◽  
pp. 57-64 ◽  
Author(s):  
Wayne Falk ◽  
R. D. James
Keyword(s):  
Bacteriophage T4 ◽  
Tail Sheath
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