scholarly journals The 12S rRNA A1555G mutation in the mitochondrial haplogroup D5a is responsible for maternally inherited hypertension and hearing loss in two Chinese pedigrees

2012 ◽  
Vol 20 (6) ◽  
pp. 607-612 ◽  
Author(s):  
Hong Chen ◽  
Jing Zheng ◽  
Ling Xue ◽  
Yanzi Meng ◽  
Yan Wang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
12S Rrna ◽  
Mitochondrial Haplogroup ◽  
A1555g Mutation

Extremely low penetrance of hearing loss in four Chinese families with the mitochondrial 12S rRNA A1555G mutation

2005 ◽  
Vol 328 (4) ◽  
pp. 1244-1251 ◽  
Author(s):  
Wie-Yen Young ◽  
Lidong Zhao ◽  
Yaping Qian ◽  
Qiuju Wang ◽  
Ning Li ◽  
...  
Keyword(s):  
Hearing Loss ◽  
12S Rrna ◽  
Chinese Families ◽  
A1555g Mutation ◽  
Mitochondrial 12S Rrna

Mitochondrial 12S rRNA A1555G mutation associated with nonsyn-dromic hearing loss in twenty-five Han Chinese pedigrees

2013 ◽  
Vol 35 (1) ◽  
pp. 62-72 ◽  
Author(s):  
Guang-Hua PENG ◽  
Bin-Jiao ZHENG ◽  
Fang FANG ◽  
Yue WU ◽  
Ling-Zhi LIANG ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Han Chinese ◽  
12S Rrna ◽  
A1555g Mutation ◽  
Mitochondrial 12S Rrna

scholarly journals Identification of a mitochondrial 12S rRNA A1555G mutation causing aminoglycoside-induced deafness in a large Thai family

2017 ◽  
Vol 9 (2) ◽  
pp. 211-215
Author(s):  
Pongsathorn Chaiyasap ◽  
Chalurmpon Srichomthong ◽  
Siraprapa Tongkobpetch ◽  
Kanya Suphapeetiporn ◽  
Vorasuk Shotelersuk
Keyword(s):  
Hearing Loss ◽  
Molecular Techniques ◽  
12S Rrna ◽  
Thai Population ◽  
Mitochondrial Mutation ◽  
Medical Practitioners ◽  
A1555g Mutation ◽  
Raising Awareness ◽  
Mitochondrial 12S Rrna ◽  
Mutation Analyses

Abstract Background Hearing loss is among the most frequent sensory disorders. Preventable causes include medications given to genetically susceptible individuals. Several families around the world with an A1555G mitochondrial mutation who became profoundly deaf after receiving aminoglycosides have been described. However, none has been reported in Thailand. Objectives To identify the cause of hearing loss of a large Thai family with 11 members who reportedly turned deaf after receiving antibiotics. Methods We obtained blood samples from 5 members; 4 of whom had hearing loss. Mutation analyses were performed using molecular techniques including polymerase chain reaction, Sanger sequencing, and restriction fragment length polymorphism. Results All 4 affected members were found to harbor the same A1555G mitochondrial mutation, while the unaffected had only the wild-type A. Conclusions We have identified the mitochondrial mutation leading to aminoglycoside-induced hearing loss in a Thai population. Raising awareness for medical practitioners of this genetic susceptibility in Thailand is warranted. Avoidance of certain medications in these individuals would prevent this acquired permanent hearing loss.

Very low penetrance of hearing loss in seven Han Chinese pedigrees carrying the deafness-associated 12S rRNA A1555G mutation

Gene ◽  
2007 ◽  
Vol 393 (1-2) ◽  
pp. 11-19 ◽  
Author(s):  
Xiaowen Tang ◽  
Li Yang ◽  
Yi Zhu ◽  
Zhisu Liao ◽  
Jindan Wang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Han Chinese ◽  
12S Rrna ◽  
A1555g Mutation

scholarly journals Mitochondrial haplogroup B increases the risk for hearing loss among the Eastern Asian pedigrees carrying 12S rRNA 1555A>G mutation

2015 ◽  
Vol 6 (11) ◽  
pp. 844-848 ◽  
Author(s):  
Zhengbiao Ying ◽  
Jing Zheng ◽  
Zhaoyang Cai ◽  
Li Liu ◽  
Yu Dai ◽  
...  
Keyword(s):  
Hearing Loss ◽  
12S Rrna ◽  
Mitochondrial Haplogroup

scholarly journals Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation

BMC Genetics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 26 ◽  
Author(s):  
Yuhua Zhu ◽  
Shasha Huang ◽  
Dongyang Kang ◽  
Mingyu Han ◽  
Guojian Wang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
12S Rrna ◽  
A1555g Mutation ◽  
Mitochondrial 12S Rrna
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