Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial

2017 ◽  
Vol 72 (1) ◽  
pp. 99-104 ◽  
Author(s):  
H Mohammadi ◽  
M Djalali ◽  
M Daneshpazhooh ◽  
N M Honarvar ◽  
C Chams‐Davatchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Lipid Profile ◽  
Controlled Trial ◽  
Pemphigus Vulgaris ◽  
Carnitine Supplementation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Biomarkers Of Oxidative Stress

scholarly journals The Multispecies Probiotic Effectively Reduces Homocysteine Concentration in Obese Women: A Randomized Double-Blind Placebo-Controlled Study

2020 ◽  
Vol 9 (4) ◽  
pp. 998 ◽  
Author(s):  
Karolina Majewska ◽  
Matylda Kręgielska-Narożna ◽  
Hieronim Jakubowski ◽  
Monika Szulińska ◽  
Paweł Bogdański
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Controlled Study ◽  
Obese Women ◽  
Bacterial Strains ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Homocysteine Concentration

Dysregulated metabolism of homocysteine (Hcy) is associated with obesity. Supplementation with probiotics can potentially be a natural therapeutic method for metabolic disorders. The precise mechanism in which microbiota affect Hcy metabolism in obese individuals is still unknown. The aim of this study was to evaluate the effects of a 12-week supplementation with a multispecies probiotic on Hcy levels, oxidative stress, inflammation and lipid profile in obese patients. This randomized double-blind placebo-controlled trial was performed on 50 obese women (aged 45–70 years). Subjects were randomly assigned to take either a multispecies probiotic supplement (n = 25) or placebo (n = 25) for 12 weeks. The probiotic contained nine bacterial strains containing 2.5 × 109 CFU/g. Biochemical and anthropometric measurements were carried out at baseline and after 12 weeks of intervention. At the end of the study, a significant decrease in Hcy, tumor necrosis factor α (TNF-α), total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglyceride (TG) levels were observed in the probiotic group. The amelioration of total antioxidant status (TAS) was also observed. The 12-week supplementation of the multispecies probiotic (Ecologic® BARIER) effectively reduced Hcy concentration, oxidative stress and inflammation, and improved the lipid profile. These multidirectional effects can potentially reduce cardiometabolic risks.

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