Chronic cholestasis in patients on parenteral nutrition: the influence of restoring bowel continuity after mesenteric infarction

2015 ◽  
Vol 70 (2) ◽  
pp. 189-193 ◽  
Author(s):  
F Adaba ◽  
M Uppara ◽  
F Iqbal ◽  
S Mallappa ◽  
C J Vaizey ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Mesenteric Infarction ◽  
Chronic Cholestasis ◽  
Bowel Continuity

PTH-196 Chronic cholestasis and parenteral nutrition: prevalence and effect of bowel restoration surgery

Gut ◽  
2015 ◽  
Vol 64 (Suppl 1) ◽  
pp. A495.2-A495
Author(s):  
F Adaba ◽  
F Iqbal ◽  
C Vaizey ◽  
S Gabe ◽  
J Warusavitarne ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Chronic Cholestasis

scholarly journals Taurine status and response to intravenous taurine supplementation in adults with short-bowel syndrome undergoing long-term parenteral nutrition: a pilot study

2006 ◽  
Vol 96 (2) ◽  
pp. 365-370 ◽  
Author(s):  
Stéphane M. Schneider ◽  
Françoise Joly ◽  
Marie-France Gehrardt ◽  
Abdul M. Badran ◽  
Anne Myara ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Bile Acids ◽  
Short Bowel Syndrome ◽  
Short Bowel ◽  
Chronic Cholestasis ◽  
Taurine Level ◽  
Taurine Deficiency ◽  
Total Bile Acids ◽  
Conjugated Bile Acids

Taurine deficiency in patients on long-term parenteral nutrition may be involved in cholestasis. We aimed to assess plasma taurine and tauro-conjugated bile acids in adults with short-bowel syndrome and their response to intravenous taurine. Thirty-two adult patients, who had been on taurine-free parenteral nutrition for a mean of 59(SE14) months for short-bowel syndrome, were studied retrospectively. In a second study, a subgroup of ten patients with chronic cholestasis received taurine-enriched (6·0(SE0·6)mg/kg per d) parenteral nutrition for 55(SE13) months. Post-absorptive plasma taurine and bile acid concentrations were measured and liver function tests routinely sampled. At baseline, plasma taurine was lower in patients with a jejunal length of less than 35cm (group A,n16) than in those with a jejunal length of 35cm or more (group B,n16): 43(SE3)v. 58(SE4)μmol/l (P=0·01). The groups were no different in terms of chronic cholestasis (1/6v.1/6 patients), total bile acids (26(SE13)v.14(SE5)μmol/l) or the ratio of tauro-conjugated:glyco-conjugated bile acids (5(SE2)v.8(SE 4)%, usual range 30–60%). After supplementation, there was an increase in plasma taurine level (63(SE8)v. 43(SE4),P=0·007) but was no change in either total bile acids or the ratio of tauro-conjugated: glyco-conjugated bile acids. There was a significant decrease in aspartate aminotransferase level. Long-term parenteral nutrition for short-bowel syndrome is associated with an impaired tauro-conjugation of bile acids (enterohepatic pool), irrespective of plasma taurine level (systemic pool) and despite long-term taurine intravenous supplementation.

Perioperative parenteral nutrition: A meta-analysis

2001 ◽  
Vol 120 (5) ◽  
pp. A263-A263
Author(s):  
R KORETZ ◽  
T LIPMAN ◽  
S KLEIN
Keyword(s):  
Parenteral Nutrition ◽  
Meta Analysis
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