scholarly journals Erratum: Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans

2015 ◽  
Vol 69 (10) ◽  
pp. 1180-1180 ◽  
Author(s):  
K E Bradbury ◽  
F L Crowe ◽  
P N Appleby ◽  
J A Schmidt ◽  
R C Travis ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Serum Concentrations ◽  
Apolipoprotein A

scholarly journals Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans

2013 ◽  
Vol 68 (2) ◽  
pp. 178-183 ◽  
Author(s):  
K E Bradbury ◽  
F L Crowe ◽  
P N Appleby ◽  
J A Schmidt ◽  
R C Travis ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Serum Concentrations ◽  
Apolipoprotein A

Serum concentrations of apolipoprotein A-I, apolipoprotein B, and lipoprotein(a) in a population sample

1995 ◽  
Vol 41 (11) ◽  
pp. 1633-1636 ◽  
Author(s):  
A Leino ◽  
O Impivaara ◽  
M Kaitsaari ◽  
J Järvisalo
Keyword(s):  
Apolipoprotein B ◽  
Population Sample ◽  
Serum Concentrations ◽  
Finnish Population ◽  
Apo B ◽  
Lipoprotein A ◽  
Apolipoprotein A ◽  
Increased Risk ◽  
Age Dependent ◽  
Age And Sex

Abstract Serum concentrations of apolipoprotein (apo) A-I, apo B, and lipoprotein(a) [Lp(a)] were studied with respect to age and sex in a Finnish population sample of 575 subjects (286 men and 289 women), ages 27-67 years. Apo A-I and apo B were measured with an immunoturbidimetric method calibrated against WHO International Reference Materials. Lp(a) was measured by RIA. Apo A-I and apo B concentrations were almost normally distributed (apo A-I: mean 1.38 g/L vs median 1.34 g/L for men, and 1.58 g/L vs 1.55 g/L for women; apo B: mean 1.21 g/L vs median 1.20 g/L for men and 1.09 g/L vs 1.05 g/L for women). The distribution of Lp(a) was remarkably skewed (mean 190 mg/L vs median 86 mg/L for men, and 169 mg/L vs 85 mg/L for women). The 95% intervals for apo A-I were 1.09-1.84 g/L for men and 1.06-2.28 g/L for women; for apo B, they were 0.63-1.88 g/L and 0.56-1.82 g/L, respectively. Apo A-I concentrations appeared to be unrelated to age, whereas apo B and Lp(a) concentrations were age-dependent. Cutoff values based on the 90th percentile for apo B and the 10th percentile for apo A-I are proposed for identifying subjects at increased risk of coronary heart disease.

scholarly journals Familial hypertriglyceridemia: an entity with distinguishable features from other causes of hypertriglyceridemia

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Ivette Cruz-Bautista ◽  
Alicia Huerta-Chagoya ◽  
Hortensia Moreno-Macías ◽  
Rosario Rodríguez-Guillén ◽  
María Luisa Ordóñez-Sánchez ◽  
...  
Keyword(s):  
Apolipoprotein B ◽  
Rare Variants ◽  
Regulatory Proteins ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Apo B ◽  
Independent Components ◽  
Apolipoprotein A

Abstract Background Familial hypertriglyceridemia (FHTG) is a partially characterized primary dyslipidemia which is frequently confused with other forms hypertriglyceridemia. The aim of this work is to search for specific features that can help physicians recognize this disease. Methods This study included 84 FHTG cases, 728 subjects with common mild-to-moderate hypertriglyceridemia (CHTG) and 609 normotriglyceridemic controls. All subjects underwent genetic, clinical and biochemical assessments. A set of 53 single nucleotide polymorphisms (SNPs) previously associated with triglycerides levels, as well as 37 rare variants within the five main genes associated with hypertriglyceridemia (i.e. LPL, APOC2, APOA5, LMF1 and GPIHBP1) were analyzed. A panel of endocrine regulatory proteins associated with triglycerides homeostasis were compared between the FHTG and CHTG groups. Results Apolipoprotein B, fibroblast growth factor 21(FGF-21), angiopoietin-like proteins 3 (ANGPTL3) and apolipoprotein A-II concentrations, were independent components of a model to detect FHTG compared with CHTG (AUC 0.948, 95%CI 0.901–0.970, 98.5% sensitivity, 92.2% specificity, P < 0.001). The polygenic set of SNPs, accounted for 1.78% of the variance in triglyceride levels in FHTG and 6.73% in CHTG. Conclusions The clinical and genetic differences observed between FHTG and CHTG supports the notion that FHTG is a unique entity, distinguishable from other causes of hypertriglyceridemia by the higher concentrations of insulin, FGF-21, ANGPTL3, apo A-II and lower levels of apo B. We propose the inclusion of these parameters as useful markers for differentiating FHTG from other causes of hypertriglyceridemia.

scholarly journals Identification of the cysteine residue in apolipoprotein(a) that mediates extracellular coupling with apolipoprotein B-100.

1993 ◽  
Vol 268 (26) ◽  
pp. 19819-19825 ◽  
Author(s):  
M.L. Koschinsky ◽  
G.P. Côté ◽  
B Gabel ◽  
Y.Y. van der Hoek
Keyword(s):  
Apolipoprotein B ◽  
Cysteine Residue ◽  
Apolipoprotein A
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