scholarly journals Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health

2014 ◽  
Vol 68 (10) ◽  
pp. 1088-1094 ◽  
Author(s):  
J A Schmidt ◽  
A Gorst-Rasmussen ◽  
P W Nyström ◽  
J H Christensen ◽  
E B Schmidt ◽  
...  
2018 ◽  
Vol 7 (6) ◽  
pp. 2391-2404 ◽  
Author(s):  
Ulrick Espelund ◽  
Andrew G. Renehan ◽  
Søren Cold ◽  
Claus Oxvig ◽  
Lee Lancashire ◽  
...  

Heart ◽  
2013 ◽  
Vol 99 (20) ◽  
pp. 1519-1524 ◽  
Author(s):  
Thomas Andersen Rix ◽  
Albert Marni Joensen ◽  
Sam Riahi ◽  
Søren Lundbye-Christensen ◽  
Kim Overvad ◽  
...  

2009 ◽  
Vol 20 (9) ◽  
pp. 1715-1721 ◽  
Author(s):  
Petra M. Witt ◽  
Jeppe H. Christensen ◽  
Erik B. Schmidt ◽  
Claus Dethlefsen ◽  
Anne Tjønneland ◽  
...  

1997 ◽  
Vol 15 (4) ◽  
pp. 1377-1384 ◽  
Author(s):  
J A Petrek ◽  
L C Hudgins ◽  
M Ho ◽  
D R Bajorunas ◽  
J Hirsch

PURPOSE Fatty acid composition of adipose tissue is an indicator of the long-term ingestion pattern of several specific fatty acids. There is good correlation of antecedent diet with the essential fatty acids, and there is reflection of the diet with the fatty acids that can be synthesized. The relationship between the fatty acid levels and lymph node status and clinical outcome was examined. METHODS At the time of diagnostic surgery, 161 women with clinical stage T1NO breast cancer had subcutaneous adipose tissue (breast and abdominal) aspirated. The concentrations of 35 fatty acids, seven summed classes, and six fatty acid groups were measured by capillary gas chromatography. Lymph node status was determined with axillary dissection, and patients were followed-up (mean, 7.3 years) for clinical outcome. RESULTS There was no significant association of any adipose tissue fatty acids with overall survival, although few (16 of 161 women) died of breast cancer. However, the odds of having positive lymph nodes (57 of 161 women) were significantly higher for women with a greater adipose tissue proportion of oleic acid (odds ratio [OR], 7.56; 95% confidence interval [CI], 1.78 to 32.1) or total saturated acids (OR, 8.43; 95% CI, 1.48 to 40.0) and significantly lower with a higher proportion of trans fatty acids (OR, 0.24; 95% CI, 0.07 to 0.77), as assessed by multivariate logistic regression. CONCLUSION These data support previous research with dietary questionnaire methodology, suggesting that specific dietary fatty acids may be associated with breast cancer promotion. Further research with long-term clinical follow-up is necessary to investigate these observations in large, diverse populations before dietary recommendations can be envisioned.


Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 465 ◽  
Author(s):  
Huaxing Wu ◽  
Cecilie Kyrø ◽  
Anne Tjønneland ◽  
Katja Boll ◽  
Anja Olsen ◽  
...  

Whole grain rye (WGR) and whole grain wheat (WGW) have been suggested to protect against the development of breast cancer. In this study, we estimated long-term intake of WGR and WGW, using both a food frequency questionnaire (FFQ) and alkylresorcinol concentrations in adipose tissue biopsies, in relation to the risk of developing invasive breast cancer in a case-cohort study (n = 414 in the case group, n = 933 in the subcohort group) on the Danish “Diet, Cancer and Health” cohort. The median follow-up time of the subcohort was 5.3 years. Total WGR and WGW intake estimated with FFQ or reflected by total alkylresorcinol concentration in adipose tissue was not significantly associated with risk of breast cancer. However, after adjustment for total WGR and WGW intake, women in the highest quartile of relative WGR intake, reflected by the alkylresorcinol C17:0/C21:0 ratio, had a higher risk of overall breast cancer and estrogen-receptor-positive (ER+) breast cancer than women in the lowest quartile of relative WGR intake, while the risk of estrogen-receptor-negative (ER-) breast cancer incidence was unaffected. Similar results were obtained with the FFQ data. Based on these data, further investigation of the role of specific grain types in reducing or increasing breast cancer risk, and their overall impact on health, is warranted.


2021 ◽  
Vol 149 ◽  
pp. 106399
Author(s):  
Amina Amadou ◽  
Delphine Praud ◽  
Thomas Coudon ◽  
Floriane Deygas ◽  
Leny Grassot ◽  
...  

Author(s):  
Trine Koch ◽  
Jeanette Therming Jørgensen ◽  
Jane Christensen ◽  
Christian Dehlendorff ◽  
Lærke Priskorn ◽  
...  

2016 ◽  
Vol 109 (2) ◽  
pp. djw204 ◽  
Author(s):  
Kirsten T. Eriksen ◽  
Jane A. McElroy ◽  
James M. Harrington ◽  
Keith E. Levine ◽  
Camilla Pedersen ◽  
...  

2016 ◽  
Vol 42 (4) ◽  
pp. 299-308 ◽  
Author(s):  
Ida EH Madsen ◽  
Ann D Larsen ◽  
Sannie V Thorsen ◽  
Jan H Pejtersen ◽  
Reiner Rugulies ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document