scholarly journals Effects of concentrated arabinoxylan and β-glucan compared with refined wheat and whole grain rye on glucose and appetite in subjects with the metabolic syndrome: a randomized study

2013 ◽  
Vol 68 (1) ◽  
pp. 84-90 ◽  
Author(s):  
M L Hartvigsen ◽  
S Gregersen ◽  
H N Lærke ◽  
J J Holst ◽  
K E Bach Knudsen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Randomized Study ◽  
Whole Grain ◽  
The Metabolic Syndrome

scholarly journals Whole Grain Rye Intake, Reflected by a Biomarker, Is Associated with Favorable Blood Lipid Outcomes in Subjects with the Metabolic Syndrome – A Randomized Study

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110827 ◽  
Author(s):  
Ola Kally Magnusdottir ◽  
Rikard Landberg ◽  
Ingibjorg Gunnarsdottir ◽  
Lieselotte Cloetens ◽  
Björn Åkesson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Randomized Study ◽  
Blood Lipid ◽  
Whole Grain ◽  
The Metabolic Syndrome

scholarly journals Effects of whole-grain wheat, rye, and lignan supplementation on cardiometabolic risk factors in men with metabolic syndrome: a randomized crossover trial

2020 ◽  
Vol 111 (4) ◽  
pp. 864-876
Author(s):  
Anne K Eriksen ◽  
Carl Brunius ◽  
Mohsen Mazidi ◽  
Per M Hellström ◽  
Ulf Risérus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Glucose Tolerance ◽  
Gut Microbiota ◽  
Ldl Cholesterol ◽  
Oral Glucose ◽  
Microbiota Composition ◽  
Whole Grain ◽  
The Metabolic Syndrome

ABSTRACT Background A whole-grain (WG)–rich diet has shown to have potential for both prevention and treatment of the metabolic syndrome (MetS), which is a cluster of risk factors that increase the risk of type 2 diabetes and cardiovascular disease. Different WGs may have different health effects. WG rye, in particular, may improve glucose homeostasis and blood lipids, possibly mediated through fermentable dietary fiber and lignans. Recent studies have also suggested a crucial role of the gut microbiota in response to WG. Objectives The aim was to investigate WG rye, alone and with lignan supplements [secoisolariciresinol diglucoside (SDG)], and WG wheat diets on glucose tolerance [oral-glucose-tolerance test (OGTT)], other cardiometabolic outcomes, enterolignans, and microbiota composition. Moreover, we exploratively evaluated the role of gut microbiota enterotypes in response to intervention diets. Methods Forty men with MetS risk profile were randomly assigned to WG diets in an 8-wk crossover study. The rye diet was supplemented with 280 mg SDG at weeks 4–8. Effects of treatment were evaluated by mixed-effects modeling, and effects on microbiota composition and the role of gut microbiota as a predictor of response to treatment were analyzed by random forest plots. Results The WG rye diet (± SDG supplements) did not affect the OGTT compared with WG wheat. Total and LDL cholesterol were lowered (−0.06 and −0.09 mmol/L, respectively; P < 0.05) after WG rye compared with WG wheat after 4 wk but not after 8 wk. WG rye resulted in higher abundance of Bifidobacterium [fold-change (FC) = 2.58, P < 0.001] compared with baseline and lower abundance of Clostridium genus compared with WG wheat (FC = 0.54, P = 0.02). The explorative analyses suggest that baseline enterotype is associated with total and LDL-cholesterol response to diet. Conclusions WG rye, alone or with SDG supplementation, compared with WG wheat did not affect glucose metabolism but caused transient LDL-cholesterol reduction. The effect of WG diets appeared to differ according to enterotype. This trial was registered at www.clinicaltrials.gov as NCT02987595.

scholarly journals Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults

2006 ◽  
Vol 83 (1) ◽  
pp. 124-131 ◽  
Author(s):  
Nadine R Sahyoun ◽  
Paul F Jacques ◽  
Xinli L Zhang ◽  
Wenyen Juan ◽  
Nicola M McKeown
Keyword(s):  
Older Adults ◽  
Metabolic Syndrome ◽  
Whole Grain ◽  
The Metabolic Syndrome

scholarly journals Postprandial effects of test meals including concentrated arabinoxylan and whole grain rye in subjects with the metabolic syndrome: a randomised study

2014 ◽  
Vol 68 (5) ◽  
pp. 567-574 ◽  
Author(s):  
M L Hartvigsen ◽  
H N Lærke ◽  
A Overgaard ◽  
J J Holst ◽  
K E Bach Knudsen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Whole Grain ◽  
Randomised Study ◽  
The Metabolic Syndrome

Dynamics of the sexual hormones level on the background of the non-hormonal correction of climacteric disorders in patients with the metabolic syndrome

2016 ◽  
Vol 10 (1) ◽  
pp. 0-0
Author(s):  
Бериханова ◽  
R. Berikhanova ◽  
Миненко ◽  
I. Minenko
Keyword(s):  
Metabolic Syndrome ◽  
Randomized Study ◽  
Follicle Stimulating Hormone ◽  
Diet Therapy ◽  
Positive Influence ◽  
Alternative Methods ◽  
Therapeutic Exercise ◽  
Sexual Hormones ◽  
Basic Group ◽  
The Metabolic Syndrome

The article presents the results of the randomized study with the participation of 120 women aged from 45 to 50 years with the metabolic syndrome. The authors determined the levels of the follicle stimulating hormone, luteinizing hormone, estradiol in the dynamics on the background of the application of different combinations of the non-hormonal methods of the correction of the disorders depending on age. On the completion of six months of therapy substantial changes in the hormonal background are revealed in the basic group of patients receiving the non-hormonal complex (diet therapy, psychotherapy, physiotherapy, the therapeutic exercise) and the orally vitamin mineral complex: a decrease in the level FSG to 35,2%, LG- to 25,2%, raising the level of estradiol by 76,3%. The obtained results demonstrate the positive influence of the association of the alternative methods of the correction of climacteric disorders in patients with MS to the hormonal profile. This suggests the pathogenetic justification of the non-drug therapy.

Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome

Nutrition ◽  
2016 ◽  
Vol 32 (2) ◽  
pp. 217-221 ◽  
Author(s):  
Claudia Vetrani ◽  
Giuseppina Costabile ◽  
Delia Luongo ◽  
Daniele Naviglio ◽  
Angela A. Rivellese ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Short Chain Fatty Acid ◽  
Chain Fatty Acid ◽  
Short Chain ◽  
Whole Grain ◽  
The Metabolic Syndrome ◽  
Whole Grain Cereal

scholarly journals Plasma Alkylresorcinol Metabolite, A Biomarker of Whole-Grain Wheat and Rye Intake, and Risk of Metabolic Syndrome: A Case-Control Study

2020 ◽  
Author(s):  
Li Zhou ◽  
Xiaoxing Mo ◽  
Qiang Wang ◽  
Hongjie Liu ◽  
Yang Liu ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
High Performance ◽  
Case Control Study ◽  
Smoking Status ◽  
Epidemiological Studies ◽  
Case Control ◽  
Whole Grain ◽  
The Metabolic Syndrome ◽  
Drinking Status ◽  
Control Study

Abstract Background: Whole-grain intake assessed through dietary recording methods has been suggested to be inversely associated with the metabolic syndrome (MetS) risk in several epidemiological studies. However, limited studies have evaluated the association between whole-grain intake and MetS risk when using objective biomarkers of whole-grain intake. The aim of this study was to examine the association between plasma 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA), a biomarker of whole-grain wheat and rye intake, and MetS risk in a Chinese population.Methods: A case-control study of 667 MetS cases and 667 matched controls was conducted based on baseline data of the Tongji-Ezhou Cohort study. Plasma DHPPA concentrations were assessed by high-performance liquid chromatography-tandem mass spectrometry. MetS was determined using definition of the Joint Interim Statement.Results: Plasma DHPPA was inversely associated with MetS risk. After adjustment for age, sex, body mass index, smoking status, alcohol drinking status, physical activity and education level, the odds ratios (ORs) for MetS across increasing quartiles of plasma DHPPA concentrations were 1 (referent), 0.86 (0.58-1.26), 0.77 (0.52-1.15), and 0.59 (0.39-0.89), respectively. The inverse relation between plasma DHPPA and MetS persisted in stratified analyses according to confounding factors. In addition, the cubic spline analysis revealed a potential nonlinear association between plasma DHPPA and MetS, with a steep reduction in the risk at the lower range of plasma DHPPA concentration.Conclusions: Our study revealed that higher plasma DHPPA concentrations were associated with lower odds of MetS. Our findings provided further evidence to support health benefits of whole grain consumption.

scholarly journals Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET)

2019 ◽  
Vol 110 (5) ◽  
pp. 1108-1118 ◽  
Author(s):  
Marjo Tuomainen ◽  
Olli Kärkkäinen ◽  
Jukka Leppänen ◽  
Seppo Auriola ◽  
Marko Lehtonen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Milk Fat ◽  
Plasma Concentrations ◽  
Metabolic Health ◽  
Spectrometric Method ◽  
Mass Spectrometric Method ◽  
Whole Grain ◽  
Nordic Diet ◽  
The Metabolic Syndrome ◽  
Fasting Plasma

ABSTRACT Background Recently, a group of betainized compounds have been suggested to play a role in health effects in relation to a whole-grain-rich diet. Objectives The aims of this study were to develop a quantitative mass spectrometric method for selected betainized compounds in human plasma, and to investigate their association with nutrient intake and measures of metabolic health in participants of the SYSDIET study. Methods The SYSDIET study was a controlled randomized intervention including individuals with metabolic syndrome, where the healthy Nordic diet (HND) group increased intakes of whole grains, canola oil, berries, and fish, whereas the control diet (CD) group consumed low-fiber cereal products, milk fat, and restricted amounts of fish and berries. A quantitative LC combined with triple quadrupole MS method for betainized compounds was developed and applied to fasting plasma samples from baseline (week 0) and the end of the intervention (week 18 or 24). Concentrations of betainized compounds were correlated with intakes of selected nutrients and fiber and measures of metabolic health. Results Pipecolic acid betaine (PAB) concentrations were significantly higher in the HND group than in the CD group (P = 0.00032) at the end of the intervention and correlated directly (P < 0.0001) with intakes of dietary fiber (r = 0.376) and a biomarker related to whole-grain rye intake, namely the ratio of alkylresorcinol C17:0 to C21:0 (r = 0.442). PAB was associated inversely with fasting plasma insulin consistently at the beginning and at the end of the intervention (P < 0.001, r = −0.300; P < 0.01, r = −0.250, respectively), as well as IL-1 receptor antagonist (P < 0.01, r = −0.232 at the beginning; P < 0.01, r = −0.236 at the end) and serum LDL/HDL cholesterol (P < 0.01, r = −0.239 at the beginning; P < 0.01, r = −0.241 at the end). Conclusions Among adults with the metabolic syndrome, PAB plasma concentrations were associated with fasting insulin, inflammation, and lipids and were significantly increased with adoption of the HND. Further studies are needed to clarify the biological functions of betainized compounds. This trial was registered at clinicaltrials.gov as NCT00992641.

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