scholarly journals Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people

2013 ◽  
Vol 67 (10) ◽  
pp. 1050-1055 ◽  
Author(s):  
M Tieland ◽  
E M Brouwer-Brolsma ◽  
C Nienaber-Rousseau ◽  
L J C van Loon ◽  
L C P G M De Groot
Keyword(s):  
Vitamin D ◽  
Elderly People ◽  
Muscle Mass ◽  
Physical Performance ◽  
Frail Elderly ◽  
Vitamin D Status ◽  
Frail Elderly People

scholarly journals Prevalence of Sarcopenia and Related Factors of Skeletal Muscle Mass in Community-dwelling Frail Elderly People

2015 ◽  
Vol 30 (5) ◽  
pp. 793-796
Author(s):  
Yoshiharu NAGAI ◽  
Masami NAKAHARA ◽  
Takeyoshi SHIMODA ◽  
Yoshirou TAKANO
Keyword(s):  
Skeletal Muscle ◽  
Elderly People ◽  
Muscle Mass ◽  
Frail Elderly ◽  
Skeletal Muscle Mass ◽  
Community Dwelling ◽  
Related Factors ◽  
Frail Elderly People

scholarly journals Serum vitamin D status inversely associates with a prevalence of severe sarcopenia among female patients with rheumatoid arthritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroto Minamino ◽  
Masao Katsushima ◽  
Mie Torii ◽  
Wataru Yamamoto ◽  
Yoshihito Fujita ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Skeletal Muscle ◽  
Vitamin D ◽  
Muscle Mass ◽  
Physical Performance ◽  
Gait Speed ◽  
Skeletal Muscle Mass ◽  
Vitamin D Status ◽  
Female Patients ◽  
High Prevalence

AbstractSarcopenia is an age-related disease with an increased risk of mortality. It is emerging that low serum 25-hydroxyvitamin D [25(OH)D] affects the sarcopenic state in general, but in rheumatoid arthritis (RA), these associations are not understood although the prevalence of vitamin D insufficiency is high in RA. We conducted a cross-sectional study of older female outpatients from our cohort (KURAMA) database. We measured skeletal muscle mass, handgrip strength, and gait-speed to diagnose severe sarcopenia. The serum 25(OH)D concentration was measured using electrochemiluminescence immunoassay. A total of 156 female patients with RA (sarcopenia:44.9%, severe sarcopenia: 29.5%, and without sarcopenia: 25.6%) were enrolled. Classification of vitamin D status at a cutoff point of median 25(OH)D concentration revealed that low 25(OH)D status was associated with a high prevalence of severe sarcopenia and with low measured values of muscle mass, handgrip, and gait speed. Furthermore, multivariable logistic regression analysis identified that low 25(OH)D status was associated with a high prevalence of severe sarcopenia (OR 6.00; 95% CI 1.99–18.08).The same association was observed when the cut-off value was set at 20 ng/ml. In components of sarcopenia, both low physical performance and muscle mass were associated with low 25(OH)D status. In conclusion, vitamin D status was inversely associated with severe sarcopenia, low physical performance, and low skeletal muscle mass. Modification of vitamin D status including vitamin D supplementation should be investigated as a therapeutic strategy for sarcopenic patients with RA.

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