scholarly journals Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study

2017 ◽  
Vol 8 (4) ◽  
pp. e91 ◽  
Author(s):  
Ronan T Gray ◽  
Marie M Cantwell ◽  
Helen G Coleman ◽  
Maurice B Loughrey ◽  
Peter Bankhead ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Pik3ca Mutation ◽  
Population Based

scholarly journals Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin use and Colon Cancer Survival in a Population-Based Cohort Study

2017 ◽  
Vol 152 (5) ◽  
pp. S1023
Author(s):  
Ronan T. Gray ◽  
Marie M. Cantwell ◽  
Helen G. Coleman ◽  
Maurice B. Loughrey ◽  
Peter Bankhead ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Pik3ca Mutation ◽  
Population Based

scholarly journals Statin use, candidate mevalonate pathway biomarkers, and colon cancer survival in a population-based cohort study

2017 ◽  
Vol 116 (12) ◽  
pp. 1652-1659 ◽  
Author(s):  
Ronan T Gray ◽  
Maurice B Loughrey ◽  
Peter Bankhead ◽  
Chris R Cardwell ◽  
Stephen McQuaid ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Mevalonate Pathway ◽  
Population Based ◽  
Statin Use

scholarly journals Statin use, Candidate Mevalonate Pathway Biomarkers, and Colon Cancer Survival in a Population-Based Cohort Study

2017 ◽  
Vol 152 (5) ◽  
pp. S1023-S1024
Author(s):  
Ronan T. Gray ◽  
Maurice B. Loughrey ◽  
Peter Bankhead ◽  
Chris Cardwell ◽  
Stephen McQuaid ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Mevalonate Pathway ◽  
Population Based ◽  
Statin Use

scholarly journals Risk of primary gastrointestinal cancers following incident non-metastatic breast cancer: a Danish population-based cohort study

2020 ◽  
Vol 7 (1) ◽  
pp. e000413
Author(s):  
Kasper Adelborg ◽  
Dóra Körmendiné Farkas ◽  
Jens Sundbøll ◽  
Lidia Schapira ◽  
Suzanne Tamang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Colon Cancer ◽  
Cohort Study ◽  
Metastatic Breast Cancer ◽  
Stomach Cancer ◽  
Metastatic Breast ◽  
Population Based ◽  
Gastrointestinal Cancers ◽  
Increased Risk

ObjectiveWe examined the risk of primary gastrointestinal cancers in women with breast cancer and compared this risk with that of the general population.DesignUsing population-based Danish registries, we conducted a cohort study of women with incident non-metastatic breast cancer (1990–2017). We computed cumulative cancer incidences and standardised incidence ratios (SIRs).ResultsAmong 84 972 patients with breast cancer, we observed 2340 gastrointestinal cancers. After 20 years of follow-up, the cumulative incidence of gastrointestinal cancers was 4%, driven mainly by colon cancers. Only risk of stomach cancer was continually increased beyond 1 year following breast cancer. The SIR for colon cancer was neutral during 2–5 years of follow-up and approximately 1.2-fold increased thereafter. For cancer of the oesophagus, the SIR was increased only during 6–10 years. There was a weak association with pancreas cancer beyond 10 years. Between 1990–2006 and 2007–2017, the 1–10 years SIR estimate decreased and reached unity for upper gastrointestinal cancers (oesophagus, stomach, and small intestine). For lower gastrointestinal cancers (colon, rectum, and anal canal), the SIR estimate was increased only after 2007. No temporal effects were observed for the remaining gastrointestinal cancers. Treatment effects were negligible.ConclusionBreast cancer survivors were at increased risk of oesophagus and stomach cancer, but only before 2007. The risk of colon cancer was increased, but only after 2007.

scholarly journals Geographical residency influences pancreatic cancer survival: a Danish nationwide population-based cohort study

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S533
Author(s):  
J. Kirkegård ◽  
M. Ladekarl ◽  
C.W. Fristrup ◽  
C. Palnæs-Hansen ◽  
M. Sall ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Population Based

scholarly journals Urban versus rural residency and pancreatic cancer survival: A Danish nationwide population-based cohort study

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202486 ◽  
Author(s):  
Jakob Kirkegård ◽  
Morten Ladekarl ◽  
Claus Wilki Fristrup ◽  
Carsten Palnæs Hansen ◽  
Mogens Sall ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Cancer Survival ◽  
Population Based ◽  
Rural Residency ◽  
Urban Versus

Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: a population-based cohort study

2018 ◽  
Vol 42 (10) ◽  
pp. 1797-1803 ◽  
Author(s):  
Britt W. Jensen ◽  
Lise G. Bjerregaard ◽  
Lars Ängquist ◽  
Ismail Gögenur ◽  
Andrew G. Renehan ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cohort Study ◽  
Weight Status ◽  
Early Adulthood ◽  
Population Based ◽  
Late Adulthood

Mutation profile of colon cancer in hispanic population of central California.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16067-e16067
Author(s):  
Sanjay Hinduja ◽  
Mir Ali ◽  
Mohammed SANI Bukari ◽  
Uzair Bashir Chaudhary ◽  
Tanner Mortenson ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Microsatellite Instability ◽  
Metastatic Disease ◽  
Pik3ca Mutation ◽  
Population Based ◽  
Metastatic Colon Cancer ◽  
Hispanic Population ◽  
Central California ◽  
Mutation Profile ◽  
Hispanic Patients

e16067 Background: The clinical and mutational profile of Hispanic patients with metastatic colon cancer is not well documented. In this retrospective study, we aim to describe the clinical and mutational profile of Hispanic patients with metastatic colon cancer in central California. Methods: We retrospectively evaluated the clinical and mutational profile of colon cancer at a single institution in Fresno, California from 2010-2019. We selected 136 patients out of which 70 patients self-identified as Hispanic and 66 self-identified as non-Hispanic. We studied clinical parameters and next-generation sequencing via Foundation one testing for these patients. Results: Among Hispanics, there were 43(61%) males and 27(38%) females. The median age at diagnosis was similar in both groups at 57. Right sided colon cancer accounted for 52% of Hispanic patients versus 40% in non-Hispanics. Fifty two percent of Hispanic patients presented with metastatic disease versus 45% in non-Hispanics. The frequency of commonly mutated genes in colon cancer in Hispanics versus non-Hispanics are as follows. KRAS (35.7% vs 37%), NRAS (11% vs 4%) BRAF (8% vs 7%), Her2/neu 0% in both groups. The frequency of other mutations such as TP53, APC, ATM, PTEN, CDKN2A, Myc amplification were also noted to be similar in both groups. PIK3CA mutation was seen in 18.6% of Hispanic patients versus 34% in non-Hispanic population which was statistically significant with a p value = 0.032. Microsatellite instability (MSI) was seen at 3.3% in Hispanics versus 10.6% in non-Hispanics. Tumor mutational burden was similar in both groups. Conclusions: The frequency of actionable mutations was similar in both Hispanic and non-Hispanic patients. Hispanics were noted to have lower PIK3CA and microsatellite instability. Metastatic disease and right sided colon cancer were seen at higher frequency in Hispanic population. Our results were similar to another population-based study which analyzed KRAS mutation with colon cancer patients in Puerto Rico[1]. Larger population based studies would be needed to further assess the differences in this patient population. Ruiz-Candelaria, Y., C. Miranda-Diaz, and R.F. Hunter-Mellado, K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011. Int J Biol Markers, 2013. 28(4): p. e393-7.

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