scholarly journals Somatic DNA Hypomethylation in H. pylori-Associated High-Risk Gastritis and Gastric Cancer: Enhanced Somatic Hypomethylation Associates with Advanced Stage Cancer

2015 ◽  
Vol 6 (4) ◽  
pp. e85 ◽  
Author(s):  
Andreas Leodolter ◽  
Sergio Alonso ◽  
Beatriz González ◽  
Matthias P Ebert ◽  
Michael Vieth ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Advanced Stage ◽  
Dna Hypomethylation ◽  
H Pylori ◽  
Advanced Stage Cancer

Eradication of H. pylori Did Not Improve Abnormal Sonic Hedgehog Expression in the High Risk Group for Gastric Cancer

2011 ◽  
Vol 57 (3) ◽  
pp. 643-649 ◽  
Author(s):  
Akiko Shiotani ◽  
Takahisa Murao ◽  
Noriya Uedo ◽  
Hiroyasu Iishi ◽  
Yoshiyuki Yamanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Sonic Hedgehog ◽  
Risk Group ◽  
High Risk Group ◽  
H Pylori

scholarly journals Cost-effectiveness ofHelicobacter pyloriscreening followed by eradication treatment for employees in Japan

2018 ◽  
Vol 146 (14) ◽  
pp. 1834-1840 ◽  
Author(s):  
A. Kowada
Keyword(s):  
Gastric Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
High Risk ◽  
Sensitivity Analyses ◽  
High Risk Population ◽  
Lifetime Horizon ◽  
Risk Population ◽  
Life Years ◽  
H Pylori

AbstractGastric cancer is the third leading cause of cancer death worldwide. Gastric cancer screening using upper gastrointestinal series, endoscopy and serological testing has been performed in population-based (employee-based and community-based) and opportunistic cancer screening in Japan. There were 45 531 gastric cancer deaths in 2016, with the low screening and detection rates.Helicobacter pylori(H. pylori) screening followed by eradication treatment is recommended in high-risk population settings to reduce gastric cancer incidence. The aim of this study was to evaluate the cost-effectiveness ofH. pyloriscreening followed by eradication treatment for a high-risk population in the occupational health setting. Decision trees and Markov models were developed for two strategies;H. pyloriantibody test (HPA) screening and no screening. Targeted populations were hypothetical cohorts of employees aged 20, 30, 40, 50 and 60 years using a company health payer perspective on a lifetime horizon. Per-person costs and effectiveness (quality-adjusted life-years) were calculated and compared. HPA screening yielded greater benefits at the lower cost than no screening. One-way and probabilistic sensitivity analyses using Monte-Carlo simulation showed strong robustness of the results.H. pyloriscreening followed by eradication treatment is recommended to prevent gastric cancer for employees in Japan, on the basis of cost-effectiveness.

scholarly journals Combined Gastric and Colorectal Cancer Screening—A New Strategy

2018 ◽  
Vol 19 (12) ◽  
pp. 3854 ◽  
Author(s):  
Michael Selgrad ◽  
Jan Bornschein ◽  
Arne Kandulski ◽  
Jochen Weigt ◽  
Albert Roessner ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Intestinal Metaplasia ◽  
Incidence Rates ◽  
Screening Colonoscopy ◽  
Serum Pepsinogen ◽  
Serum Samples ◽  
Serological Screening ◽  
Increased Risk ◽  
H Pylori

Background: Our aim was to evaluate the feasibility of a serological assessment of gastric cancer risk in patients undergoing colonoscopy in countries with low-to-moderate incidence rates. Methods: Serum samples were prospectively collected from 453 patients (>50 years old) undergoing colonoscopies. Of these, 279 (61.6%) also underwent gastroscopy to correlate the results for serum pepsinogen I and II (sPG-I and sPG-II), sPG-I/II ratio, and anti-H. pylori antibodies with gastric histopathology findings (graded according to the updated Sydney classification and the Operative Link of Gastritis Assessment (OLGA) and the Operative Link for Gastric Intestinal Metaplasia assessment (OLGIM) systems). Results: H. pylori was found in 85 patients (30.5%). Chronic atrophic gastritis was diagnosed in 89 (31.9%) patients. High-risk OLGA (III–IV) stages were present in 24 patients, and high-risk OLGIM stages were present in 14 patients. There was an inverse correlation of sPG-I with the degree of atrophy and intestinal metaplasia (IM), as well as with the respective OLGA (r = −0.425; p < 0.001) and OLGIM (r = −0.303; p < 0.001) stages. A pathological sPG-I result was associated with a relative risk (RR) of 12.2 (95% confidence interval: 6.29–23.54; p < 0.001) for gastric preneoplastic changes. Conclusions: The assessment of serum pepsinogen allows the identification of patients at increased risk of gastric cancer. A prevention strategy of combining a screening colonoscopy with a serological screening for preneoplastic gastric changes should be considered in the general population.

Mo1167 Magnifying Image-Enhanced Endoscopy for Diagnosis of Gastric Atrophy and H. Pylori Infection in a Amerindian Population With a High-Risk of Gastric Cancer

2017 ◽  
Vol 85 (5) ◽  
pp. AB446
Author(s):  
Pablo Cortés ◽  
Antonio Rollán ◽  
Robinson G. Gonzalez ◽  
María E. Bufadel ◽  
Raúl Araya ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Gastric Atrophy ◽  
Amerindian Population ◽  
H Pylori

Gene Diversity of H. pylori cagPAI Genes in Patients with Gastroduodenal Diseases in a Region at High Risk of Gastric Cancer

2014 ◽  
Vol 55 (1) ◽  
pp. 118-120 ◽  
Author(s):  
Ming-yi Wang ◽  
Chen Shao ◽  
Jie Li ◽  
Xiao-yan Wang ◽  
Shao-bo Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Gene Diversity ◽  
H Pylori

scholarly journals Prevalence of cagA, vacA, babA2 and iceA Genes in Helicobacter pylori Strains Isolated from Colombian Patients with Functional Dyspepsia

2012 ◽  
Vol 61 (1) ◽  
pp. 33-40 ◽  
Author(s):  
AZUCENA ARÉVALO-GALVIS ◽  
ALBA A. TRESPALACIOS-RANGEL ◽  
WILLIAM OTERO ◽  
MARCELA M. MERCADO-REYES ◽  
RAÚL A. POUTOU-PIÑALES
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Molecular Markers ◽  
High Risk ◽  
Functional Dyspepsia ◽  
Allelic Variants ◽  
High Prevalence ◽  
History Of ◽  
H Pylori ◽  
New Evidence

The clinical outcome of Helicobacter pylori infection has been particularly associated with virulence genotypes. These genotypes are useful as molecular markers in the identification of patients that are infected and at high risk for developing more severe gastric pathologies. Our main objective was to determine the prevalence of virulence genotypes cagA, vacA, iceA and babA2 of H. pylori, in patients with functional dyspepsia who are infected with the bacteria. H. pylori genotypes babA2 and cagA as well as vacA and iceA allelic variants were identified by PCR in 122 isolates resulting from 79 patients with functional dyspepsia. A high prevalence of genes cagA+ (71%), vacAs1am1 (34%), babA2 (57%) and iceA1 (87%) was found. The most frequent combined genotype found were cagA+/vacAs1am1/babA2+/iceA1 and cagA-/vacAs1am1/babA2+/iceA1, regardless of any family history of gastric cancer or MALT lymphoma. The very virulent genotype cagA+/vacAs1am1/babA2+/iceA1 prevailed in the studied patients with functional dyspepsia. Our results provide information about the prevalence of four of the more important virulent factors and constitute new evidence on the prevalence of the most virulent H. pylori genotype in patients with functional dyspepsia.

scholarly journals [ARTICLE PARTIAL RETRACTION] PREVALENCE OF HELICOBACTER PYLORI INFECTION IN DYSPEPTIC PATIENTS AND ITS ASSOCIATION WITH CLINICAL RISK FACTORS FOR DEVELOPING GASTRIC ADENOCARCINOMA

2019 ◽  
Vol 56 (1) ◽  
pp. 66-70
Author(s):  
Stéfani Sousa BORGES ◽  
Amanda Ferreira Paes Landim RAMOS ◽  
Aroldo Vieira de MORAES FILHO ◽  
Carla Afonso da Silva Bitencourt BRAGA ◽  
Lilian Carla CARNEIRO ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
High Risk ◽  
Gastric Adenocarcinoma ◽  
Public Health Problem ◽  
Clinical Risk Factors ◽  
International Agency ◽  
Clinical Risk ◽  
H Pylori

ABSTRACT BACKGROUND: In Brazil, particularly in the underdeveloped localities, the prevalence of Helicobacter pylori (H. pylori) infections can range up to 90%. These rates are higher in older individuals and vary by country region. H. pylori infections are linked to the development of gastric pathologies, namely mild to moderate gastritis, gastroenteritis, peptic ulcer, intestinal metaplasia, and gastric cancer. In 1994, this organism was classified by the International Agency for Research on Cancer (IARC) as pertaining to the Group 1 carcinogen for gastric adenocarcinoma etiology. Gastric cancer represents a significant public health problem, being the fourth most common malignant tumor and the second largest cause of cancer-related deaths. OBJECTIVE: To investigate the prevalence of H. pylori infection in dyspeptic patients and determine the link between clinical risk factors and gastric adenocarcinoma diagnosis. METHODS: Polymerase chain reaction (PCR) analysis was employed for molecular diagnosis of gastric tissue biopsies collected from 113 dyspeptic patients at the University Hospital of Federal University of Goiás. Molecular analyses allowed the identification of H. pylori infections. Furthermore, histopathological examinations were performed to determine the clinical risks of developing gastric malignancies. RESULTS: The test results identified 69 individuals older than 44 years, from 75 (66.4%) positive H. pylori infection samples. The prevalence of gastric adenocarcinoma in this study was 1.3%. Among the infected patients, six (8.2%) had high risk, and 67 (91.8%) had a low risk of developing gastric cancer (P<0.05). CONCLUSION: This study shows a high prevalence of H. pylori infection and identifies its contribution to gastric inflammations, which in the long term are manifested in high-risk clinical factors for the development of gastric adenocarcinoma.

Mo1556 High-Risk Host Genotype and H. pylori Strains in First Degree Relatives of Patients With Early-Onset Gastric Cancer

2012 ◽  
Vol 142 (5) ◽  
pp. S-627-S-628
Author(s):  
Ricardo Marcos-Pinto ◽  
Mario J. Dinis-Ribeiro ◽  
Fátima Carneiro ◽  
Jose C. Machado ◽  
Ceu Figueiredo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Early Onset ◽  
Host Genotype ◽  
First Degree Relatives ◽  
H Pylori

T2067 Prospective Analysis of Metachronous Early Gastric Cancer in High Risk Patients After H. pylori Eradication

2008 ◽  
Vol 134 (4) ◽  
pp. A-612
Author(s):  
Akiko Shiotani ◽  
Noriya Uedo ◽  
Tomoari Kamada ◽  
Hiroyasu Iishi ◽  
Masaharu Tatsuta ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Risk ◽  
Early Gastric Cancer ◽  
Prospective Analysis ◽  
High Risk Patients ◽  
Risk Patients ◽  
H Pylori
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