scholarly journals Significant Evidence of Linkage for a Gene Predisposing to Colorectal Cancer and Multiple Primary Cancers on 22q11

2014 ◽  
Vol 5 (2) ◽  
pp. e50 ◽  
Author(s):  
Craig Teerlink ◽  
Quentin Nelson ◽  
Randall Burt ◽  
Lisa Cannon-Albright
Keyword(s):  
Colorectal Cancer ◽  
Multiple Primary Cancers ◽  
Significant Evidence ◽  
Multiple Primary

Multiple Primary Cancers Including Colorectal Cancer

2008 ◽  
Vol 24 (6) ◽  
pp. 467 ◽  
Author(s):  
Soo Hong Kim ◽  
Hyung Jin Kim ◽  
Jae Im Lee ◽  
Yoon Suk Lee ◽  
Won Kyung Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary

scholarly journals Colorectal cancer in cases of multiple primary cancers: Clinical features of 59 cases and point mutation analyses

2017 ◽  
Vol 13 (6) ◽  
pp. 4720-4726 ◽  
Author(s):  
Anshan Wu ◽  
Siqi He ◽  
Jingjing Li ◽  
Ling Liu ◽  
Chunlan Liu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Point Mutation ◽  
Clinical Features ◽  
Multiple Primary Cancers ◽  
Multiple Primary ◽  
Mutation Analyses

Multiple primary cancers in extracolonic sites with colorectal cancer

2008 ◽  
Vol 24 (3) ◽  
pp. 301-304 ◽  
Author(s):  
Seung-Hyun Lee ◽  
Byung-Kwon Ahn ◽  
Sung-Uhn Baek
Keyword(s):  
Colorectal Cancer ◽  
Multiple Primary Cancers ◽  
Multiple Primary

Clinical analysis of multiple primary cancers

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 19639-19639
Author(s):  
K. Lee ◽  
H. Jang ◽  
M. Choi ◽  
J. Kong ◽  
S. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gastric Cancer ◽  
University Hospital ◽  
Survival Duration ◽  
Multiple Primary Cancers ◽  
Second Primary ◽  
Female Ratio ◽  
Genitourinary Cancer ◽  
Multiple Primary ◽  
Synchronous Cancers

19639 Background: Multiple primary cancers are defined as two or more abnormal growths of tissue occurring simultaneously or abnormal growths of tissues that follow a previous neoplasm but are not metastases of the latter in the same individual. The primary objective of this study was to determine the occurrence, clinical characteristics and prognosis of multiple primary cancers in single institution, respectively. Methods: Between January 1995 and June 2006, patients with multiple primary cancers were selected from a review of patients who had been treated and followed-up in our Ewha Womans University Hospital. Demographic data were obtained from medical records. Results: Two hundred seven patients were selected and patients with multiple primary cancers constituted 1.95% of all malignancies. Male to female ratio was 1.84. (male 134 vs. female 73 patients) The median age first cancer diagnosis was 67 years old in male, 57 in female. The incidence of synchronous cancers is higher than metachronous. (108 vs. 99) and the median time to additional cancers in metachronous group was 35 months. The most frequent cancers was gastrointestinal cancers in both sex synchronously and metachronously. In male, colorectal cancer followed by gastric cancer methchronously (9.1%), genitourinary cancer with another genitourinary cancer synchronously (12.7%) were frequently observed. In female, breast cancer followed by colorectal cancer metachronously (6.8%), gastric cancer with colorectal cancer (6.9%) were frequently observed. The median survival duration was 14.4 months totally from the index diagnosis and synchronous cancers showed lower survival duration than metachronous cancers. (7.4 vs. 26.1 months, p=0.017) Conclusions: Adequate investigations including G-I tract should focus in the first 3 years after initial diagnosis to detect second primary cancers earlier. No significant financial relationships to disclose.

scholarly journals Are relatives of patients with multiple HNPCC spectrum tumours at increased risk of cancer?

Gut ◽  
1998 ◽  
Vol 43 (5) ◽  
pp. 664-668 ◽  
Author(s):  
S R Brown ◽  
P J Finan ◽  
D T Bishop
Keyword(s):  
Colorectal Cancer ◽  
General Population ◽  
Comparison Group ◽  
Structured Interview ◽  
Multiple Primary Cancers ◽  
Study Group ◽  
Increased Risk ◽  
Multiple Primary ◽  
Close Relatives ◽  
Risk Of Cancer

Background—Relatives of patients with early onset colorectal cancer, a feature of hereditary non-polyposis colorectal cancer (HNPCC), are at increased risk of colorectal cancer.Aims—To investigate risk in relatives of patients with multiple primary cancers, another feature of HNPCC.Methods—Details were obtained on patients from one region who had developed colorectal cancer and a separate primary from the HNPCC tumour spectrum (colorectal, stomach, urinary, ovary, endometrial). Overall, 157 patients had second primaries occurring between 1990 and 1995 and 128 completed family histories were obtained by structured interview (study group). A comparison group of 444 patients with a single colorectal cancer were similarly interviewed.Results—Fifteen families (13%) from the study group were suggestive of HNPCC compared with three (0.7%, p<0.0001) from the comparison group. Overall risk of colorectal cancer in close relatives of the study group was 3.4 times the general population rate compared with 1.8 times for the comparison group. Bowel cancer risk was even higher for relatives of bowel/ovary and bowel/endometrial subgroups, but was similar to the comparison group for the bowel/bowel subgroup. Finally, extracolonic HNPCC associated cancers were seen twice as frequently as expected in the general population in relatives of the study group.Conclusion—This study highlights the importance of taking a family history in patients with multiple primary cancers and indicates the risk of malignancy in their relatives.

Diagnosis and Treatment of Multiple Primary Cancers of the Cervicofacial and Esophageal Regions

2011 ◽  
Vol 62 (2) ◽  
pp. 158-158
Author(s):  
S. Ohta ◽  
Y. Nakajima ◽  
T. Okada ◽  
Jirawat Swangsri ◽  
A. Hoshino ◽  
...  
Keyword(s):  
Diagnosis And Treatment ◽  
Multiple Primary Cancers ◽  
Multiple Primary
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