scholarly journals Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes

Cell Research ◽  
2016 ◽  
Vol 26 (2) ◽  
pp. 206-216 ◽  
Author(s):  
Xiao-Lei Shi ◽  
Yimeng Gao ◽  
Yupeng Yan ◽  
Hucheng Ma ◽  
Lulu Sun ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Bioartificial Liver ◽  
Bioartificial Liver Device

scholarly journals The study of albumin dialysis efficiency in acute liver failure using the «Bioartificial liver» device

2015 ◽  
Vol 96 (5) ◽  
pp. 768-771
Author(s):  
E E Polevshchikova
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Biochemical Markers ◽  
Clinical Signs ◽  
Human Albumin ◽  
Bioartificial Liver ◽  
Experimental Sample ◽  
Albumin Solution ◽  
Albumin Dialysis ◽  
Bioartificial Liver Device

Aim. Clinical testing of albumin dialysis method in patients with acute liver failure of different etiologies on the experimental sample of the «bioartificial liver» device. Methods. Clinical assessment of treatment using the «bioartificial liver» device was conducted on 20 patients aged 22-68 years old who had acute liver failure of different etiology. The «bioartificial liver» device consisted of a perfusion unit, the dialyzer, dialysis circuit with albumin solution and carbon haemosorbent mode. A 10% donor human albumin solution was used as the dialysis fluid in recirculation mode. For restoration of the accepting ability albumin was exposed to perfusion through the carbonic hemosorbent. Duration of the treatment was 3 hours, control of liver damage biochemical markers was performed before and after the session. Results. There was a statistically significant reduction in biochemical markers of cytolysis and cholestasis: transaminases, alkaline phosphatase and bilirubin levels. We also observed a statistically significant reduction of ammonia level, which is one of the main clinical and laboratory signs characterizing the severity of encephalopathy. Improvement of liver synthetic function reflected a statistically significant increase in glucose level. Clinical stabilization as well as reduction of encephalopathy clinical signs were observed after the procedure. No side effects were notices. Conclusion. Implementation of albumin dialysis in patients with acute liver failure using the «bioartificial liver» device was accompanied by an improvement of their functional state. This gives reason to use this method for the treatment of acute liver failure in intensive care units.

DEMONSTRATION OF THE EFFICIENCY OF A BIOARTIFICIAL LIVER IN A POTENTIALLY REVERSIBLE LARGE ANIMAL MODEL OF ACUTE LIVER FAILURE.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S405
Author(s):  
I. Fourneau ◽  
S. H. Yap ◽  
T. Roskams ◽  
L. Flendrig ◽  
R. Chamuleau ◽  
...  
Keyword(s):  
Animal Model ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Bioartificial Liver ◽  
Large Animal Model ◽  
Large Animal

Effects of acute-liver-failure-plasma exposure on hepatic functionality of HepaRG-AMC-Bioartificial Liver

2013 ◽  
Vol 33 (4) ◽  
pp. 516-524 ◽  
Author(s):  
Geert A. A. Nibourg ◽  
Ruurdtje Hoekstra ◽  
Tessa V. van der Hoeven ◽  
Mariëtte T. Ackermans ◽  
Theodorus B. M. Hakvoort ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Bioartificial Liver ◽  
Plasma Exposure

NEUROLOGICAL IMPROVEMENT DURING BIOARTIFICIAL LIVER SESSIONS IN PATIENTS WITH ACUTE LIVER FAILURE AWAITING TRANSPLANTATION1

2002 ◽  
Vol 73 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Didier Samuel ◽  
Philippe Ichai ◽  
Cyrille Feray ◽  
Faouzi Saliba ◽  
Daniel Azoulay ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Bioartificial Liver ◽  
Neurological Improvement

Bridging a Patient with Acute Liver Failure to Liver Transplantation by the AMC-Bioartificial Liver

2003 ◽  
Vol 12 (6) ◽  
pp. 563-568 ◽  
Author(s):  
Maarten-Paul Van De Kerkhove ◽  
Ernesto Di Florio ◽  
Vincenzo Scuderi ◽  
Antonio Mancini ◽  
Antonello Belli ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Bioartificial Liver
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