scholarly journals p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

Cell Research ◽  
2015 ◽  
Vol 25 (3) ◽  
pp. 351-369 ◽  
Author(s):  
Lu Gong ◽  
Hongjian Gong ◽  
Xiao Pan ◽  
Changqing Chang ◽  
Zhao Ou ◽  
...  
Keyword(s):  
Dna Damage ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair

scholarly journals Epigenetic Mechanisms in DNA Double Strand Break Repair: A Clinical Review

2021 ◽  
Vol 8 ◽  
Author(s):  
Alejandra Fernandez ◽  
Connor O’Leary ◽  
Kenneth J O’Byrne ◽  
Joshua Burgess ◽  
Derek J Richard ◽  
...  
Keyword(s):  
Dna Damage ◽  
Chromatin Structure ◽  
Dna Methyltransferase ◽  
Strand Break ◽  
Dna Methyltransferases ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Epigenetic Mechanisms ◽  
Dna Double Strand Break ◽  
Break Repair

Upon the induction of DNA damage, the chromatin structure unwinds to allow access to enzymes to catalyse the repair. The regulation of the winding and unwinding of chromatin occurs via epigenetic modifications, which can alter gene expression without changing the DNA sequence. Epigenetic mechanisms such as histone acetylation and DNA methylation are known to be reversible and have been indicated to play different roles in the repair of DNA. More importantly, the inhibition of such mechanisms has been reported to play a role in the repair of double strand breaks, the most detrimental type of DNA damage. This occurs by manipulating the chromatin structure and the expression of essential proteins that are critical for homologous recombination and non-homologous end joining repair pathways. Inhibitors of histone deacetylases and DNA methyltransferases have demonstrated efficacy in the clinic and represent a promising approach for cancer therapy. The aims of this review are to summarise the role of histone deacetylase and DNA methyltransferase inhibitors involved in DNA double strand break repair and explore their current and future independent use in combination with other DNA repair inhibitors or pre-existing therapies in the clinic.

scholarly journals The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

PLoS Genetics ◽  
2010 ◽  
Vol 6 (7) ◽  
pp. e1001025 ◽  
Author(s):  
Aymeric P. Bailly ◽  
Alasdair Freeman ◽  
Julie Hall ◽  
Anne-Cécile Déclais ◽  
Arno Alpi ◽  
...  
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Damage Signaling ◽  
Dna Double Strand Break ◽  
Break Repair

scholarly journals BCL10 is recruited to sites of DNA damage to facilitate DNA double-strand break repair

Cell Cycle ◽  
2016 ◽  
Vol 15 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Ismail Hassan Ismail ◽  
Ashley Dronyk ◽  
Xiuying Hu ◽  
Michael J. Hendzel ◽  
Andrew R. Shaw
Keyword(s):  
Dna Damage ◽  
Strand Break ◽  
Double Strand Break ◽  
Double Strand Break Repair ◽  
Dna Double Strand Break ◽  
Break Repair
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