scholarly journals Probing hepatocyte heterogeneity

Cell Research ◽  
2015 ◽  
Vol 25 (11) ◽  
pp. 1181-1182 ◽  
Author(s):  
Ben Z Stanger
Keyword(s):  
Hepatocyte Heterogeneity

scholarly journals Liver Zonation – Revisiting Old Questions With New Technologies

2021 ◽  
Vol 12 ◽  
Author(s):  
Rory P. Cunningham ◽  
Natalie Porat-Shliom
Keyword(s):  
Liver Disease ◽  
Spatial Organization ◽  
New Technologies ◽  
Single Cell Analysis ◽  
Normal Liver ◽  
Alcoholic Fatty Liver ◽  
Liver Zonation ◽  
Hepatocyte Heterogeneity ◽  
Glucose And Lipid Homeostasis ◽  
Technological Limitations

Despite the ever-increasing prevalence of non-alcoholic fatty liver disease (NAFLD), the etiology and pathogenesis remain poorly understood. This is due, in part, to the liver’s complex physiology and architecture. The liver maintains glucose and lipid homeostasis by coordinating numerous metabolic processes with great efficiency. This is made possible by the spatial compartmentalization of metabolic pathways a phenomenon known as liver zonation. Despite the importance of zonation to normal liver function, it is unresolved if and how perturbations to liver zonation can drive hepatic pathophysiology and NAFLD development. While hepatocyte heterogeneity has been identified over a century ago, its examination had been severely hindered due to technological limitations. Recent advances in single cell analysis and imaging technologies now permit further characterization of cells across the liver lobule. This review summarizes the advances in examining liver zonation and elucidating its regulatory role in liver physiology and pathology. Understanding the spatial organization of metabolism is vital to further our knowledge of liver disease and to provide targeted therapeutic avenues.

Hepatocyte Heterogeneity in Bile Formation and Hepatobiliary Transport of Drugs

Enzyme ◽  
1992 ◽  
Vol 46 (1-3) ◽  
pp. 94-138 ◽  
Author(s):  
G.M.M. Groothuis ◽  
D.K.F. Meijer
Keyword(s):  
Bile Formation ◽  
Hepatobiliary Transport ◽  
Hepatocyte Heterogeneity

scholarly journals Hepatocyte heterogeneity in response to extracellular ATP

1987 ◽  
Vol 169 (3) ◽  
pp. 645-650 ◽  
Author(s):  
Dieter HAUSSINGER ◽  
Thomas STEHLE ◽  
Wolfgang GEROK ◽  
Thuy-Anh TRAN-THI ◽  
Karl DECKER
Keyword(s):  
Extracellular Atp ◽  
Hepatocyte Heterogeneity

Sa1497 NOVEL TECHNIQUE FOR ISOLATION OF HEPATOCYTES FROM NEEDLE BIOPSIES TO STUDY HEPATOCYTE HETEROGENEITY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1311
Author(s):  
Sindhura T. Batchu ◽  
Deviana Burhan ◽  
Rasika Patkar ◽  
Bruce Wang
Keyword(s):  
Novel Technique ◽  
Hepatocyte Heterogeneity
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