scholarly journals Stereotyped distribution of midbody remnants in early C. elegans embryos requires cell death genes and is dispensable for development

Cell Research ◽  
2013 ◽  
Vol 24 (2) ◽  
pp. 251-253 ◽  
Author(s):  
Guangshuo Ou ◽  
Christian Gentili ◽  
Pierre Gönczy
Keyword(s):  
Cell Death ◽  
C Elegans ◽  
Cell Death Genes ◽  
Death Genes

scholarly journals Apoptotic regulators promote cytokinetic midbody degradation in C. elegans

2012 ◽  
Vol 199 (7) ◽  
pp. 1047-1055 ◽  
Author(s):  
Yongping Chai ◽  
Dong Tian ◽  
Yihong Yang ◽  
Guoxin Feng ◽  
Ze Cheng ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Division ◽  
Daughter Cell ◽  
Apoptotic Cell ◽  
Imaging Analysis ◽  
C Elegans ◽  
Cellular Events ◽  
Cell Death Genes ◽  
Death Genes ◽  
Cell Engulfment

Cell death genes are essential for apoptosis and other cellular events, but their nonapoptotic functions are not well understood. The midbody is an important cytokinetic structure required for daughter cell abscission, but its fate after cell division remains elusive in metazoans. In this paper, we show through live-imaging analysis that midbodies generated by Q cell divisions in Caenorhabditis elegans were released to the extracellular space after abscission and subsequently internalized and degraded by the phagocyte that digests apoptotic Q cell corpses. We further show that midbody degradation is defective in apoptotic cell engulfment mutants. Externalized phosphatidylserine (PS), an engulfment signal for corpse phagocytosis, exists on the outer surface of the midbody, and inhibiting PS signaling delayed midbody clearance. Thus, our findings uncover a novel function of cell death genes in midbody internalization and degradation after cell division.

scholarly journals Network Analysis Identifies Drug Targets and Small Molecules to Modulate Apoptosis Resistant Cancers

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 851
Author(s):  
Samreen Fathima ◽  
Swati Sinha ◽  
Sainitin Donakonda
Keyword(s):  
Cell Death ◽  
Small Molecules ◽  
Drug Targets ◽  
Apoptotic Cell ◽  
Colon Adenocarcinoma ◽  
Interaction Networks ◽  
Small Cell Lung ◽  
Protein Protein Interaction ◽  
Cell Death Genes ◽  
Death Genes

Programed cell death or apoptosis fails to induce cell death in many recalcitrant cancers. Thus, there is an emerging need to activate the alternate cell death pathways in such cancers. In this study, we analyzed the apoptosis-resistant colon adenocarcinoma, glioblastoma multiforme, and small cell lung cancers transcriptome profiles. We extracted clusters of non-apoptotic cell death genes from each cancer to understand functional networks affected by these genes and their role in the induction of cell death when apoptosis fails. We identified transcription factors regulating cell death genes and protein–protein interaction networks to understand their role in regulating cell death mechanisms. Topological analysis of networks yielded FANCD2 (ferroptosis, negative regulator, down), NCOA4 (ferroptosis, up), IKBKB (alkaliptosis, down), and RHOA (entotic cell death, down) as potential drug targets in colon adenocarcinoma, glioblastoma multiforme, small cell lung cancer phenotypes respectively. We also assessed the miRNA association with the drug targets. We identified tumor growth-related interacting partners based on the pathway information of drug-target interaction networks. The protein–protein interaction binding site between the drug targets and their interacting proteins provided an opportunity to identify small molecules that can modulate the activity of functional cell death interactions in each cancer. Overall, our systematic screening of non-apoptotic cell death-related genes uncovered targets helpful for cancer therapy.

scholarly journals 1779 Cell Death Genes are Induced Immediately after Hypoxia-Reoxygenation (HR) in the Newborn Mouse Lung

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A503-A503
Author(s):  
E. Wollen ◽  
A. Rognlien ◽  
M. Atneosen-Asegg ◽  
M. Wright ◽  
M. Bjoras ◽  
...  
Keyword(s):  
Cell Death ◽  
Mouse Lung ◽  
Newborn Mouse ◽  
Cell Death Genes ◽  
Death Genes ◽  
Hypoxia Reoxygenation

Interleukin-1α-converting enzyme (ICE) and related cell death genes ICErel-II and ICErel-III map to the same PAC clone at band 11q22.2-22.3

1997 ◽  
Vol 8 (8) ◽  
pp. 611-613 ◽  
Author(s):  
Jamal Nasir ◽  
Jane L. Theilmann ◽  
John P. Vaillancourt ◽  
Neil A. Munday ◽  
Ambereen Ali ◽  
...  
Keyword(s):  
Cell Death ◽  
Converting Enzyme ◽  
Related Cell ◽  
Interleukin 1Α ◽  
Cell Death Genes ◽  
Death Genes

scholarly journals Native cell-death genes as candidates for developing wilt resistance in transgenic banana plants

AoB Plants ◽  
2014 ◽  
Vol 6 (0) ◽  
pp. plu037-plu037 ◽  
Author(s):  
S. B. Ghag ◽  
U. K. S. Shekhawat ◽  
T. R. Ganapathi
Keyword(s):  
Cell Death ◽  
Wilt Resistance ◽  
Native Cell ◽  
Transgenic Banana ◽  
Cell Death Genes ◽  
Death Genes
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