scholarly journals Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells

Cell Research ◽  
2011 ◽  
Vol 22 (3) ◽  
pp. 607-610 ◽  
Author(s):  
Zhijian Cai ◽  
Wei Zhang ◽  
Fei Yang ◽  
Lei Yu ◽  
Zhou Yu ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Autoimmune Disease ◽  
Regulatory T Cells ◽  
Inflammatory Autoimmune Disease ◽  
Tgf Β1

scholarly journals Human Dendritic Cells Produce TGF-β1 under the Influence of Lung Carcinoma Cells and Prime the Differentiation of CD4+CD25+Foxp3+Regulatory T Cells

2009 ◽  
Vol 182 (5) ◽  
pp. 2795-2807 ◽  
Author(s):  
Ingrid E. Dumitriu ◽  
Donald R. Dunbar ◽  
Sarah E. Howie ◽  
Tariq Sethi ◽  
Christopher D. Gregory
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Lung Carcinoma ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Dendritic Cells ◽  
Tgf Β1

scholarly journals Dendritic Cells With TGF-β1 and IL-2 Differentiate Naive CD4+ T Cells Into Alloantigen-Specific and Allograft Protective Foxp3+ Regulatory T Cells

2012 ◽  
Vol 93 (6) ◽  
pp. 580-588 ◽  
Author(s):  
Hua Yang ◽  
Elaine Y. Cheng ◽  
Vijay K. Sharma ◽  
Mila Lagman ◽  
Christina Chang ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
Cd4 T Cells ◽  
Tgf Β1

scholarly journals Emerging Cellular Therapies for Anti-myeloperoxidase Vasculitis and Other Autoimmune Diseases

2021 ◽  
Vol 12 ◽  
Author(s):  
Dragana Odobasic ◽  
Stephen R. Holdsworth
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Dendritic Cells ◽  
Autoimmune Disease ◽  
Regulatory T Cells ◽  
Adverse Effects ◽  
Autoimmune Diseases ◽  
Cellular Therapies ◽  
Tolerogenic Dendritic Cells ◽  
Life Threatening

Anti-myeloperoxidase vasculitis (MPO-AAV) is a life-threatening autoimmune disease which causes severe inflammation of small blood vessels, mainly in the kidney. As for many other autoimmune diseases, current treatments, which consist of general immunosuppressants, are partially effective, toxic and broadly immunosuppressive, causing significant and serious adverse effects in many patients. Therefore, there is an urgent need for more targeted and less harmful therapies. Tolerogenic dendritic cells, regulatory T cells and stem cells have emerged as attractive, new and safer options for the treatment for various autoimmune diseases due to their unique and selective immunosuppressive capacity. In this review, we will discuss how these cellular therapies offer potential to become novel and safer treatments for MPO-AAV.

Induction of porcine-specific regulatory T cells with high specificity and expression of IL-10 and TGF-β1 using baboon-derived tolerogenic dendritic cells

2017 ◽  
Vol 25 (1) ◽  
pp. e12355 ◽  
Author(s):  
Mingqian Li ◽  
Judith Eckl ◽  
Jan-Michael Abicht ◽  
Tanja Mayr ◽  
Bruno Reichart ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Regulatory T Cells ◽  
High Specificity ◽  
Tolerogenic Dendritic Cells ◽  
Tgf Β1

TGF-β1-induced regulatory T cells

2015 ◽  
Vol 76 (8) ◽  
pp. 561-564 ◽  
Author(s):  
Eva N. Hadaschik ◽  
Alexander H. Enk
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Tgf Β1

scholarly journals FOXP3 Defines Regulatory T Cells in Human Tumor and Autoimmune Disease

2009 ◽  
Vol 69 (9) ◽  
pp. 3995-4000 ◽  
Author(s):  
Ilona Kryczek ◽  
Rebecca Liu ◽  
Guobin Wang ◽  
Ke Wu ◽  
Xiaogong Shu ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
Regulatory T Cells ◽  
Human Tumor
Sign in / Sign up

Export Citation Format

Share Document