scholarly journals The integrative roles of chemokines at the maternal–fetal interface in early pregnancy

2014 ◽  
Vol 11 (5) ◽  
pp. 438-448 ◽  
Author(s):  
Mei-Rong Du ◽  
Song-Cun Wang ◽  
Da-Jin Li
Keyword(s):  
Early Pregnancy ◽  
Maternal Fetal Interface

HTRA3 Expression in Non-pregnant Rhesus Monkey Ovary and Endometrium, and at the Maternal-Fetal Interface During Early Pregnancy.

2008 ◽  
Vol 78 (Suppl_1) ◽  
pp. 61-61
Author(s):  
Marissa A. Bowden ◽  
Ying Li ◽  
Jock K. Findlay ◽  
Lois A. Salamonsen ◽  
Guiying Nie
Keyword(s):  
Rhesus Monkey ◽  
Early Pregnancy ◽  
Maternal Fetal Interface

scholarly journals Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires

2019 ◽  
Vol 20 (3) ◽  
pp. 687 ◽  
Author(s):  
Antonia Terzieva ◽  
Violeta Dimitrova ◽  
Lyubomir Djerov ◽  
Petya Dimitrova ◽  
Silvina Zapryanova ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Γδ T Cells ◽  
Γδ T Cell ◽  
Maternal Immune System ◽  
Human Decidua ◽  
Maternal Fetal Interface

Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of harmful responses towards the fetus and ability to fight infections. TCR γδ cells have been implicated in the responses in infectious diseases, in the regulation of immune responses, and in tissue homeostasis and repair. The variety of functions makes γδ T cells a particularly interesting population during pregnancy. In this study, we investigated the proportion, phenotype and TCR γ and δ repertoires of γδ T cells at the maternal–fetal interface and in the blood of pregnant women using FACS, immunohistochemistry and spectratyping. We found an enrichment of activated and terminally differentiated pro-inflammatory γδ T-cell effectors with specific location in the human decidua during early pregnancy, while no significant changes in their counterparts in the blood of pregnant women were observed. Our spectratyping data revealed polyclonal CDR3 repertoires of the δ1, δ2 and δ3 chains and γ2, γ3, γ4 and γ5 chains and oligoclonal and highly restricted CDR3γ9 repertoire of γδ T cells in the decidua and blood of pregnant women. Early pregnancy induces recruitment of differentiated pro-inflammatory γδ T-cell effectors with diverse TCR repertoires at the maternal–fetal interface.

scholarly journals Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis

2020 ◽  
Vol 105 (12) ◽  
pp. e4275-e4289
Author(s):  
Banqin Wang ◽  
Tonghui Xu ◽  
Yan Li ◽  
Wenfu Wang ◽  
Chunzi Lyu ◽  
...  
Keyword(s):  
Spontaneous Abortion ◽  
Early Pregnancy ◽  
Human Placenta ◽  
Deoxyribonucleic Acid ◽  
Recurrent Spontaneous Abortion ◽  
Migration And Invasion ◽  
T Helper ◽  
Trophoblast Cells ◽  
Maternal Fetal Interface

Abstract Context Dysregulated immune hemostasis occurs in unexplained recurrent spontaneous abortion (URSA). Synthesized by cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE), hydrogen sulfide (H2S) promotes regulatory T-cell differentiation and regulates immune hemostasis; yet, its role in URSA is elusive. Objective To determine if H2S plays a role in early pregnancy and if dysregulated H2S signaling results in recurrent spontaneous abortion. Design First trimester placenta villi and decidua were collected from normal and URSA pregnancies. Protein expression was examined by immunohistochemistry and immunoblotting. Human trophoblast HTR8/SVneo and JEG3 cells were treated with H2S donors; HTR8/SVneo cells were transfected with CBS ribonucleic acid interference (RNAi) or complementary deoxyribonucleic acid. Cell migration and invasion were determined by transwell assays; trophoblast transcriptomes were determined by RNA sequencing (RNA-seq). Wild-type, CBS-deficient, and CBA/J × DBA/2 mice were treated with CBS and CSE inhibitors or H2S donors to determine the role of H2S in early pregnancy in vivo. Results CBS and CSE proteins showed cell-specific expressions, but only CBS decreased in the villous cytotrophoblast in URSA versus normal participants. H2S donors promoted migration and invasion and MMP-2 and VEGF expression in human placenta trophoblast cells that contain SV40 viral deoxyribonucleic acid sequences (HTR8/SVneo) and human placenta trophoblast cells (JEG3 cells), similar to forced CBS expression in HTR8/SVneo cells. The CBS-responsive transcriptomes in HTR8/SVneo cells contained differentially regulated genes (ie, interleukin-1 receptor and prostaglandin-endoperoxide synthase 2) that are associated with nuclear factor-κB-mediated inflammatory response. In vivo, dysregulated CBS/H2S signaling significantly increased embryonic resorption and decidual T-helper 1/T-helper 2 imbalance in mice, which was partially rescued by H2S donors. Conclusion CBS/H2S signaling maintains early pregnancy, possibly via regulating maternal-fetal interface immune hemostasis, offering opportunities for H2S-based immunotherapies for URSA.

scholarly journals Remodelling at the maternal–fetal interface: relevance to human pregnancy disorders

Reproduction ◽  
2010 ◽  
Vol 140 (6) ◽  
pp. 803-813 ◽  
Author(s):  
Judith E Cartwright ◽  
Rupsha Fraser ◽  
Karin Leslie ◽  
Alison E Wallace ◽  
Joanna L James
Keyword(s):  
Early Pregnancy ◽  
Immune Cells ◽  
Active Role ◽  
Maternal Blood ◽  
Placental Development ◽  
Successful Pregnancy ◽  
Human Pregnancy ◽  
Healthy Pregnancy ◽  
Maternal Fetal Interface ◽  
Pregnancy Disorders

In human pregnancy, successful placentation and remodelling of the uterine vasculature require the integration of a number of stages, which are crucial for a healthy pregnancy. As the demands of the developing fetus for nutrients and oxygen increase, the capacity of the maternal blood vessels to supply this must be altered radically, with deficiencies in this process implicated in a number of dangerous pregnancy complications. The complex signalling networks that regulate these tightly co-ordinated events are becoming clearer as more studies of early pregnancy are performed. It is the aim of this review to draw together our knowledge of events that occur to facilitate a successful pregnancy ranging from the preparation for implantation, through the invasion and differentiation of the trophoblast and the regulation of these processes by other cells within the decidual environment, to the active role that the trophoblast and maternal immune cells play in facilitating the remodelling of the uterine spiral arteries. The events involved in a healthy pregnancy will then be compared to aberrant placentation and remodelling, which are characteristics of many pregnancy disorders, and recent advances in detection of abnormal placental development will also be discussed.

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