scholarly journals The shrimp IKK–NF-κB signaling pathway regulates antimicrobial peptide expression and may be subverted by white spot syndrome virus to facilitate viral gene expression

2013 ◽  
Vol 10 (5) ◽  
pp. 423-436 ◽  
Author(s):  
Pei-Hui Wang ◽  
Zhi-Hua Gu ◽  
Ding-Hui Wan ◽  
Bo-Du Liu ◽  
Xian-De Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Antimicrobial Peptide ◽  
Signaling Pathway ◽  
White Spot Syndrome Virus ◽  
Viral Gene Expression ◽  
White Spot ◽  
Viral Gene ◽  
Peptide Expression ◽  
White Spot Syndrome ◽  
Antimicrobial Peptide Expression

Transcriptome analysis reveals differential gene expression associated with white spot syndrome virus resistance in the shrimp Litopenaeus vannamei fed on functional diets

Aquaculture ◽  
2022 ◽  
Vol 547 ◽  
pp. 737434
Author(s):  
Monica Janeth Cabrera-Stevens ◽  
Arturo Sánchez-Paz ◽  
Fernando Mendoza-Cano ◽  
Cristina Escobedo-Fregoso ◽  
Trinidad Encinas-García ◽  
...  
Keyword(s):  
Gene Expression ◽  
Differential Gene Expression ◽  
Transcriptome Analysis ◽  
Litopenaeus Vannamei ◽  
Virus Resistance ◽  
White Spot Syndrome Virus ◽  
White Spot ◽  
Differential Gene ◽  
White Spot Syndrome

scholarly journals Two White Spot Syndrome Virus MicroRNAs Target the Dorsal Gene To Promote Virus Infection in Marsupenaeus japonicus Shrimp

2017 ◽  
Vol 91 (8) ◽  
Author(s):  
Qian Ren ◽  
Xin Huang ◽  
Yalei Cui ◽  
Jiejie Sun ◽  
Wen Wang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Signaling Pathway ◽  
White Spot Syndrome Virus ◽  
Regulation Of Gene Expression ◽  
White Spot ◽  
Viral Mirnas ◽  
Host Interactions ◽  
Toll Signaling ◽  
White Spot Syndrome

ABSTRACT In eukaryotes, microRNAs (miRNAs) serve as regulators of many biological processes, including virus infection. An miRNA can generally target diverse genes during virus-host interactions. However, the regulation of gene expression by multiple miRNAs has not yet been extensively explored during virus infection. This study found that the Spaztle (Spz)-Toll-Dorsal-antilipopolysaccharide factor (ALF) signaling pathway plays a very important role in antiviral immunity against invasion of white spot syndrome virus (WSSV) in shrimp (Marsupenaeus japonicus). Dorsal, the central gene in the Toll pathway, was targeted by two viral miRNAs (WSSV-miR-N13 and WSSV-miR-N23) during WSSV infection. The regulation of Dorsal expression by viral miRNAs suppressed the Spz-Toll-Dorsal-ALF signaling pathway in shrimp in vivo, leading to virus infection. Our study contributes novel insights into the viral miRNA-mediated Toll signaling pathway during the virus-host interaction. IMPORTANCE An miRNA can target diverse genes during virus-host interactions. However, the regulation of gene expression by multiple miRNAs during virus infection has not yet been extensively explored. The results of this study indicated that the shrimp Dorsal gene, the central gene in the Toll pathway, was targeted by two viral miRNAs during infection with white spot syndrome virus. Regulation of Dorsal expression by viral miRNAs suppressed the Spz-Toll-Dorsal-ALF signaling pathway in shrimp in vivo, leading to virus infection. Our study provides new insight into the viral miRNA-mediated Toll signaling pathway in virus-host interactions.

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