scholarly journals CD4+ T cell-released exosomes inhibit CD8+ cytotoxic T-lymphocyte responses and antitumor immunity

2010 ◽  
Vol 8 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Haifeng Zhang ◽  
Yufeng Xie ◽  
Wei Li ◽  
Rajni Chibbar ◽  
Sidong Xiong ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Antitumor Immunity ◽  
Cytotoxic T Lymphocyte ◽  
Cd4 T Cell ◽  
Lymphocyte Responses

Anti-HIV Type 1 Memory Cytotoxic T Lymphocyte Responses Associated with Changes in CD4+T Cell Numbers in Progression of HIV Type 1 Infection

1998 ◽  
Vol 14 (16) ◽  
pp. 1423-1433 ◽  
Author(s):  
CHARLES R. RINALDO ◽  
PHALGUNI GUPTA ◽  
XIAO-LI HUANG ◽  
ZHENG FAN ◽  
JAMES I. MULLINS ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Cd4 T Cell ◽  
Cell Numbers ◽  
Hiv Type 1 ◽  
Lymphocyte Responses ◽  
Anti Hiv

scholarly journals Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Can Regulate Dendritic Cell–induced Activation and Cytotoxicity of CD8+ T Cells Independently of CD4+T Cell Help

1999 ◽  
Vol 189 (7) ◽  
pp. 1157-1162 ◽  
Author(s):  
Kathy D. McCoy ◽  
Ian F. Hermans ◽  
J. Henry Fraser ◽  
Graham Le Gros ◽  
Franca Ronchese
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Lymphocyte ◽  
Cd8 T Cells ◽  
Cytotoxic T Lymphocyte ◽  
Cd4 T Cell ◽  
Cd4 T Cell Help ◽  
T Cell Help

The mechanisms that regulate the strength and duration of CD8+ cytotoxic T cell activity determine the effectiveness of an antitumor immune response. To better understand the antitumor effects of anti-cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) antibody treatment, we analyzed the effect of CTLA-4 signaling on CD8+ T cells in vitro and in vivo. In vitro, cross-linking of CTLA-4 on purified CD8+ T cells caused decreased proliferative responses to anti-CD3 stimulation and rapid loss of activation marker expression. In vivo, blockade of CTLA-4 by neutralizing anti–CTLA-4 mAb greatly enhanced the accumulation, activation, and cytotoxic activity of CD8+ T cells induced by immunization with Ag on dendritic cells (DC). This enhanced response did not require the expression of MHC class II molecules on DC or the presence of CD4+ T cells. These results demonstrate that CTLA-4 blockade is able to directly enhance the proliferation and activation of specific CD8+ T cells, indicating its potential for tumor immunotherapy even in situations in which CD4+ T cell help is limited or absent.

T CELL HELP IN CYTOTOXIC T LYMPHOCYTE RESPONSES

1983 ◽  
Vol 35 (1) ◽  
pp. 78-83 ◽  
Author(s):  
SHMUEL LIVNAT ◽  
RONALD B. CORLEY
Keyword(s):  
T Cell ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Responses ◽  
T Cell Help

scholarly journals Cytotoxic T Lymphocyte Antigen-4 Blockade Enhances Antitumor Immunity by Stimulating Melanoma-Specific T-cell Motility

2014 ◽  
Vol 2 (10) ◽  
pp. 970-980 ◽  
Author(s):  
Tsvetelina Pentcheva-Hoang ◽  
Tyler R. Simpson ◽  
Welby Montalvo-Ortiz ◽  
James P. Allison
Keyword(s):  
T Cell ◽  
Cell Motility ◽  
T Lymphocyte ◽  
Antitumor Immunity ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen
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