scholarly journals Loss of microRNAs in thymus perturbs invariant NKT cell development and function

2010 ◽  
Vol 7 (6) ◽  
pp. 447-453 ◽  
Author(s):  
Kook-Heon Seo ◽  
Li Zhou ◽  
Dongmei Meng ◽  
Jianrui Xu ◽  
Zhong Dong ◽  
...  
Keyword(s):  
Cell Development ◽  
Nkt Cell ◽  
And Function ◽  
Invariant Nkt Cell

Invariant NKT cell development and function in microRNA-223 knockout mice

2011 ◽  
Vol 11 (5) ◽  
pp. 561-568 ◽  
Author(s):  
Kai Li ◽  
Kook-Heon Seo ◽  
Tianwen Gao ◽  
Quanhui Zheng ◽  
Rui-Qun Qi ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Cell Development ◽  
Nkt Cell ◽  
And Function ◽  
Invariant Nkt Cell

scholarly journals MicroRNA miR-150 Is Involved in Vα14 Invariant NKT Cell Development and Function

2012 ◽  
Vol 188 (5) ◽  
pp. 2118-2126 ◽  
Author(s):  
Quanhui Zheng ◽  
Li Zhou ◽  
Qing-Sheng Mi
Keyword(s):  
Cell Development ◽  
Nkt Cell ◽  
And Function ◽  
Invariant Nkt Cell

scholarly journals Regulation of invariant NKT cell development and function by a 0.14 Mbp locus on chromosome 1: a possible role for Fcgr3

2018 ◽  
Vol 20 (4) ◽  
pp. 261-272 ◽  
Author(s):  
Victoria L. DeVault ◽  
Murisa Malagic ◽  
Linda Mei ◽  
Oliver Dienz ◽  
Graham W. J. Lilley ◽  
...  
Keyword(s):  
Cell Development ◽  
Chromosome 1 ◽  
Nkt Cell ◽  
And Function ◽  
Invariant Nkt Cell

scholarly journals A Cell-Type Specific CD1d Expression Program Modulates Invariant NKT Cell Development and Function

2006 ◽  
Vol 176 (3) ◽  
pp. 1421-1430 ◽  
Author(s):  
Michael I. Zimmer ◽  
Angela Colmone ◽  
Kyrie Felio ◽  
Honglin Xu ◽  
Averil Ma ◽  
...  
Keyword(s):  
Cell Development ◽  
Cell Type ◽  
Nkt Cell ◽  
A Cell ◽  
Cell Type Specific ◽  
And Function ◽  
Expression Program ◽  
Invariant Nkt Cell

scholarly journals Invariant NKT Cell Development Requires a Full Complement of Functional CD3 ζ Immunoreceptor Tyrosine-Based Activation Motifs

2010 ◽  
Vol 184 (12) ◽  
pp. 6822-6832 ◽  
Author(s):  
Amy M. Becker ◽  
Jon S. Blevins ◽  
Farol L. Tomson ◽  
Jennifer L. Eitson ◽  
Jennifer J. Medeiros ◽  
...  
Keyword(s):  
Cell Development ◽  
Nkt Cell ◽  
Full Complement ◽  
Invariant Nkt Cell

scholarly journals Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells

Blood ◽  
2011 ◽  
Vol 117 (6) ◽  
pp. 1880-1887 ◽  
Author(s):  
Hak-Jong Choi ◽  
Yanbiao Geng ◽  
Hoonsik Cho ◽  
Sha Li ◽  
Pramod Kumar Giri ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Transcription Factors ◽  
Nk Cells ◽  
Nk Cell ◽  
Nkt Cells ◽  
Cell Development ◽  
Intrinsic Defect ◽  
Nkt Cell ◽  
Ets Family ◽  
And Function

Abstract E26 Transformation specific (Ets) family transcription factors control the expression of a large number of genes regulating hematopoietic cell development and function. Two such transcription factors, Ets-1 and myeloid Elf-1–like factor (MEF), have been shown to play critical roles in both natural killer (NK)– and NKT-cell development, but not in the development of conventional T cells. In this study, we address the role of E74-like factor 1 (Elf-1), another Ets family transcription factor that is closely related to MEF but divergent from Ets-1, in NK- and NKT-cell development using Elf-1–deficient (Elf-1−/−) mice. Whereas the proportion of NK cells in Elf-1−/− mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1−/− mice compared with wild-type (WT) mice. Although Ets-1–deficient mice lack NKT cells altogether, Elf-1−/− mice exhibited only a partial block in NKT-cell development caused by a cell-intrinsic defect in the selection, survival, and maturation of NKT cells. In addition, residual NKT cells found in Elf-1−/− mice produced less cytokine upon antigen stimulation compared with WT NKT cells. Our data demonstrate that Elf-1 plays an important and nonredundant role in the development and function of NKT cells, but is not involved in NK-cell development.

scholarly journals Essential Functions for ID Proteins at Multiple Checkpoints in Invariant NKT Cell Development

2013 ◽  
Vol 191 (12) ◽  
pp. 5973-5983 ◽  
Author(s):  
Mihalis Verykokakis ◽  
Veena Krishnamoorthy ◽  
Antonio Iavarone ◽  
Anna Lasorella ◽  
Mikael Sigvardsson ◽  
...  
Keyword(s):  
Cell Development ◽  
Nkt Cell ◽  
Id Proteins ◽  
Invariant Nkt Cell
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