Human Endotoxin Administration as an Experimental Model in Drug Development

A F Suffredini; R J Noveck

doi:10.1038/clpt.2014.146

Human Endotoxin Administration as an Experimental Model in Drug Development

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2014.146 ◽

2014 ◽

Vol 96 (4) ◽

pp. 418-422 ◽

Cited By ~ 25

Author(s):

A F Suffredini ◽

R J Noveck

Keyword(s):

Drug Development ◽

Experimental Model ◽

Endotoxin Administration

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Abnormal behavior of the rat as an experimental model useful in psychotherapeutic drug development.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)37730-3 ◽

1991 ◽

Vol 55 ◽

pp. 10

Author(s):

Showa Ueki

Keyword(s):

Drug Development ◽

Experimental Model ◽

Abnormal Behavior ◽

Psychotherapeutic Drug

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Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects

Journal of Endotoxin Research ◽

10.1177/0968051907085986 ◽

2007 ◽

Vol 13 (5) ◽

pp. 251-279 ◽

Cited By ~ 61

Author(s):

Marjan Bahador ◽

Alan S. Cross

Keyword(s):

Experimental Model ◽

Human Subjects ◽

Endotoxin Administration

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Ultrastructural Alterations in Sinusoidal Endothelial Fenestrae as a Result of Hypoxia

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100090828 ◽

1976 ◽

Vol 34 ◽

pp. 168-169

Author(s):

Waykin Nopanitaya ◽

Raeford E. Brown ◽

Joe W. Grisham ◽

Johnny L. Carson

Keyword(s):

Endothelial Cells ◽

Experimental Model ◽

Hepatic Lobule ◽

Ultrastructural Alterations ◽

Large Type ◽

Sinusoidal Endothelial Fenestrae ◽

General Size ◽

Sem Studies

Mammalian endothelial cells lining hepatic sinusoids have been found to be widely fenestrated. Previous SEM studies (1,2) have noted two general size catagories of fenestrations; large fenestrae were distributed randomly while the small type occurred in groups. These investigations also reported that large fenestrae were more numerous and larger in the endothelial cells at the afferent ends of sinusoids or around the portal areas, whereas small fenestrae were more numerous around the centrilobular portion of the hepatic lobule. It has been further suggested that under some physiologic conditions small fenestrae could fuse and subsequently become the large type, but this is, as yet, unproven.We have used a reproducible experimental model of hypoxia to study the ultrastructural alterations in sinusoidal endothelial fenestrations in order to investigate the origin of occurrence of large fenestrae.

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