A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

K K Machavaram; L M Almond; A Rostami-Hodjegan; I Gardner; M Jamei; S Tay; S Wong; A Joshi; J R Kenny

doi:10.1038/clpt.2013.79

A Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease–Drug Interactions: Suppression of CYP3A by IL-6

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2013.79 ◽

2013 ◽

Vol 94 (2) ◽

pp. 260-268 ◽

Cited By ~ 49

Author(s):

K K Machavaram ◽

L M Almond ◽

A Rostami-Hodjegan ◽

I Gardner ◽

M Jamei ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Guide Optimal Dosing Regimens for Imatinib and Potential Drug Interactions in Paediatrics

Frontiers in Pharmacology ◽

10.3389/fphar.2019.01672 ◽

2020 ◽

Vol 10 ◽

Cited By ~ 2

Author(s):

Jeffry Adiwidjaja ◽

Alan V. Boddy ◽

Andrew J. McLachlan

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Potential Drug ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Optimal Dosing ◽

Physiologically Based ◽

Dosing Regimens

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A physiologically based pharmacokinetic modeling approach to predict drug-drug interactions between domperidone and inhibitors of CYP3A4

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1992 ◽

2016 ◽

Vol 37 (1) ◽

pp. 15-27 ◽

Cited By ~ 8

Author(s):

Ian Templeton ◽

Paulien Ravenstijn ◽

Carlo Sensenhauser ◽

Jan Snoeys

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug–Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients

Drug Metabolism and Disposition ◽

10.1124/dmd.116.073585 ◽

2017 ◽

Vol 45 (4) ◽

pp. 361-374 ◽

Cited By ~ 4

Author(s):

Heidi J. Einolf ◽

Jocelyn Zhou ◽

Christina Won ◽

Lai Wang ◽

Sam Rebello

Keyword(s):

Drug Interactions ◽

Cancer Patients ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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A Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug-Drug Interactions of Buprenorphine After Subcutaneous Administration of CAM2038 With Perpetrators of CYP3A4

Journal of Pharmaceutical Sciences ◽

10.1016/j.xphs.2017.10.035 ◽

2018 ◽

Vol 107 (3) ◽

pp. 942-948

Author(s):

Tao Liu ◽

Jogarao V.S. Gobburu

Keyword(s):

Drug Interactions ◽

Subcutaneous Administration ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic modeling to predict complex drug-drug interactions: a case study of AZD2327 and its metabolite, competitive and time-dependent CYP3A inhibitors

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1962 ◽

2015 ◽

Vol 36 (8) ◽

pp. 507-519 ◽

Cited By ~ 4

Author(s):

Jian Guo ◽

Diansong Zhou ◽

Yan Li ◽

Bui H. Khanh

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Complex Drug

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Pain Chemogenomics Knowledgebase (Pain-CKB) for Systems Pharmacology Target Mapping and Physiologically Based Pharmacokinetic Modeling Investigation of Opioid Drug–Drug Interactions

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00372 ◽

2020 ◽

Vol 11 (20) ◽

pp. 3245-3258

Author(s):

Mingzhe Shen ◽

Maozi Chen ◽

Tianjian Liang ◽

Siyi Wang ◽

Ying Xue ◽

...

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Systems Pharmacology ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically‐Based Pharmacokinetic Modeling for Predicting Drug Interactions of a Combination of Olanzapine and Samidorphan

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12488 ◽

2020 ◽

Vol 9 (2) ◽

pp. 106-114 ◽

Cited By ~ 2

Author(s):

Lei Sun ◽

Lisa Moltke ◽

Karen Rowland Yeo

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2017.11.011 ◽

2018 ◽

Vol 112 ◽

pp. 168-179 ◽

Cited By ~ 28

Author(s):

Yumi Yamamoto ◽

Pyry A. Välitalo ◽

Yin Cheong Wong ◽

Dymphy R. Huntjens ◽

Johannes H. Proost ◽

...

Keyword(s):

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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Physiologically based pharmacokinetic modeling of disposition and drug–drug interactions for atorvastatin and its metabolites

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2015.06.019 ◽

2015 ◽

Vol 77 ◽

pp. 216-229 ◽

Cited By ~ 18

Author(s):

Tao Zhang

Keyword(s):

Drug Interactions ◽

Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic Modeling ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based

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