Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

M Reilly; R M Miller; M H Thomson; V Patris; P Ryle; L McLoughlin; P Mutch; P Gilboy; C Miller; M Broekema; B Keogh; W McCormack; J van de Wetering de Rooij

doi:10.1038/clpt.2013.150

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.2013.150 ◽

2013 ◽

Vol 94 (5) ◽

pp. 593-600 ◽

Cited By ~ 67

Author(s):

M Reilly ◽

R M Miller ◽

M H Thomson ◽

V Patris ◽

P Ryle ◽

...

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Double Blind ◽

Double Blind Placebo ◽

Dose Escalating

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Randomised, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I Study of QGC001, a Centrally Acting Aminopeptidase A Inhibitor Prodrug

Clinical Pharmacokinetics ◽

10.1007/s40262-013-0125-y ◽

2013 ◽

Vol 53 (4) ◽

pp. 385-395 ◽

Cited By ~ 33

Author(s):

Fabrice Balavoine ◽

Michel Azizi ◽

Damien Bergerot ◽

Nadia De Mota ◽

Rémi Patouret ◽

...

Keyword(s):

Phase I ◽

Phase I Study ◽

Double Blind ◽

Double Blind Placebo ◽

Aminopeptidase A ◽

Aminopeptidase A Inhibitor ◽

Dose Escalating

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First-in-human safety, tolerability, and pharmacokinetics of ammoxetine in healthy subjects: a randomized, double-blind, placebo-controlled phase I study

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2021.105724 ◽

2021 ◽

Vol 159 ◽

pp. 105724

Author(s):

Qi Shen ◽

Chao Hu ◽

Jia Miao ◽

Junxia Chen ◽

Yueying Peng ◽

...

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Phase I Study ◽

Double Blind ◽

Double Blind Placebo ◽

Human Safety

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A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

CNS Drugs ◽

10.1007/s40263-018-0578-5 ◽

2018 ◽

Vol 32 (11) ◽

pp. 1053-1067 ◽

Cited By ~ 84

Author(s):

Lesley Taylor ◽

Barry Gidal ◽

Graham Blakey ◽

Bola Tayo ◽

Gilmour Morrison

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Multiple Dose ◽

Food Effect ◽

Double Blind ◽

Double Blind Placebo

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A Phase I, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects Receiving Codeine or Placebo: 2017 Fellows-in-Training Award (Functional Bowel Disease Category) 2017 Presidential Poster Award

The American Journal of Gastroenterology ◽

10.14309/00000434-201710001-00431 ◽

2017 ◽

Vol 112 ◽

pp. S230 ◽

Cited By ~ 1

Author(s):

Houssam Halawi ◽

Priya Vijayvargiya ◽

Irene Busciglio ◽

Ibironke Oduyebo ◽

Disha Khemani ◽

...

Keyword(s):

Small Bowel ◽

Phase I ◽

Bowel Disease ◽

Healthy Subjects ◽

Colonic Transit ◽

Controlled Study ◽

Disease Category ◽

Double Blind ◽

Double Blind Placebo ◽

Poster Award

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(420) NEO6860, a novel modality selective TRPV1 antagonist: results from a phase I, double-blind, placebo-controlled study in healthy subjects

Journal of Pain ◽

10.1016/j.jpain.2016.01.397 ◽

2016 ◽

Vol 17 (4) ◽

pp. S79 ◽

Cited By ~ 9

Author(s):

D. Chiche ◽

W. Brown ◽

P. Walker

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Controlled Study ◽

Double Blind ◽

Double Blind Placebo ◽

Trpv1 Antagonist

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A Phase I, Randomized, Double‐Blind, Placebo‐Controlled, Single‐Dose and Multiple‐Rising‐Dose Study of the BTK Inhibitor TAK‐020 in Healthy Subjects

Clinical and Translational Science ◽

10.1111/cts.12871 ◽

2021 ◽

Author(s):

Ehsanollah Esfandiari ◽

Mary Chen ◽

Glennda Smithson ◽

Derek Blair ◽

Helene Faessel ◽

...

Keyword(s):

Single Dose ◽

Phase I ◽

Healthy Subjects ◽

Double Blind ◽

Double Blind Placebo ◽

Dose Study ◽

Btk Inhibitor

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A Phase I Clinical Study of a Live Attenuated Bordetella pertussis Vaccine - BPZE1; A Single Centre, Double-Blind, Placebo-Controlled, Dose-Escalating Study of BPZE1 Given Intranasally to Healthy Adult Male Volunteers

PLoS ONE ◽

10.1371/journal.pone.0083449 ◽

2014 ◽

Vol 9 (1) ◽

pp. e83449 ◽

Cited By ~ 77

Author(s):

Rigmor Thorstensson ◽

Birger Trollfors ◽

Nabil Al-Tawil ◽

Maja Jahnmatz ◽

Jakob Bergström ◽

...

Keyword(s):

Clinical Study ◽

Phase I ◽

Pertussis Vaccine ◽

Bordetella Pertussis ◽

Healthy Adult ◽

Single Centre ◽

Double Blind ◽

Double Blind Placebo ◽

Healthy Adult Male ◽

Dose Escalating

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Correction to: A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects

CNS Drugs ◽

10.1007/s40263-019-00617-3 ◽

2019 ◽

Vol 33 (4) ◽

pp. 397-397

Author(s):

Lesley Taylor ◽

Barry Gidal ◽

Graham Blakey ◽

Bola Tayo ◽

Gilmour Morrison

Keyword(s):

Phase I ◽

Healthy Subjects ◽

Multiple Dose ◽

Food Effect ◽

Double Blind ◽

Double Blind Placebo

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Faculty Opinions recommendation of Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718212176.793529345 ◽

2017 ◽

Author(s):

Paul Drawz

Keyword(s):

Phase I ◽

Phase I Study ◽

Double Blind ◽

Double Blind Placebo ◽

Aminopeptidase A ◽

Aminopeptidase A Inhibitor ◽

Dose Escalating

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A phase 1, randomized, double-blind, placebo-controlled dose-escalating, safety, tolerability, pharmacokinetic, and pharmacodynamic study of oral recombinant human interleukin eleven (O-rhIl-11) in normal healthy subjects

Gastroenterology ◽

10.1016/s0016-5085(03)81907-8 ◽

2003 ◽

Vol 124 (4) ◽

pp. A377 ◽

Cited By ~ 1

Author(s):

Monette M. Cotreau ◽

Lucille Stonis ◽

Ullrich S. Schwertschlag

Keyword(s):

Healthy Subjects ◽

Phase 1 ◽

Double Blind ◽

Double Blind Placebo ◽

Pharmacodynamic Study ◽

Dose Escalating

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