Pharmacological Treatment of Acute Heart Failure: Current Treatment and New Targets

2013 ◽  
Vol 94 (4) ◽  
pp. 499-508 ◽  
Author(s):  
J Pöss ◽  
A Link ◽  
M Böhm
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Pharmacological Treatment ◽  
Current Treatment ◽  
New Targets

scholarly journals Identification of Lactate as a Cardiac Protectant by Inhibiting Inflammation and Cardiac Hypertrophy Using a Zebrafish Acute Heart Failure Model

2021 ◽  
Vol 14 (3) ◽  
pp. 261
Author(s):  
Elijah R. Haege ◽  
Hui-Chi Huang ◽  
Cheng-chen Huang
Keyword(s):  
Heart Failure ◽  
Cardiac Hypertrophy ◽  
Acute Heart Failure ◽  
Symptom Relief ◽  
Cardiac Contractility ◽  
Mapk Signaling ◽  
Current Treatment ◽  
Chemical Fractionation ◽  
Biological Tests ◽  
Heart Failure Model

Acute heart failure (AHF) commonly arises from decompensated chronic heart failure or sudden structural and functional breakdown causing a decrease in cardiac contractility and consequently fluid accumulation and systemic congestion. Current treatment for AHF aims at reducing fluid overload and improving hemodynamic which results in quick symptom relief but still poor prognostic outcome. This study utilizes a zebrafish AHF model induced by aristolochic acid (AA) to look for natural products that could attenuate the progression of AHF. The project started off by testing nearly seventy herbal crude extracts. Two of the positive extracts were from Chinese water chestnuts and are further studied in this report. After several rounds of chromatographical chemical fractionation and biological tests, a near pure fraction, named A2-4-2-4, with several hydrophilic compounds was found to attenuate the AA-induced AHF. A2-4-2-4 appeared to inhibit inflammation and cardiac hypertrophy by reducing MAPK signaling activity. Chemical analyses revealed that the major compound in A2-4-2-4 is actually lactate. Pure sodium lactate showed attenuation of the AA-induced AHF and inflammation and cardiac hypertrophy suppression as well, suggesting that the AHF attenuation ability in A2-4-2-4 is attributable to lactate. Our studies identify lactate as a cardiac protectant and a new therapeutic agent for AHF.

Biomarkers in diagnosing and treatment of acute heart failure

2019 ◽  
Vol 13 (14) ◽  
pp. 1235-1249 ◽  
Author(s):  
Leili Pourafkari ◽  
Arezou Tajlil ◽  
Nader D Nader
Keyword(s):  
Heart Failure ◽  
Risk Stratification ◽  
Acute Heart Failure ◽  
Natriuretic Peptides ◽  
Morbidity And Mortality ◽  
Disease Monitoring ◽  
New Targets ◽  
Complex Disorder ◽  
Cardiac Troponins

Acute heart failure (AHF) is a complex disorder involving different pathophysiological pathways. In recent years, there is an increased focus on biomarkers that help with diagnosis, risk stratification and disease monitoring of AHF. Finding a reliable set of biomarkers not only improves morbidity and mortality but it can also potentially reveal the new targets of therapy. In this paper, we have reviewed the biomarkers found useful for the diagnosis as well as for risk stratification and prognostication in patients with AHF. We have discussed the established biomarkers for AHF including cardiac troponins and natriuretic peptides and emerging biomarkers including adiponectin, mi-RNA, sST2, Gal-3, MR-proADM, OPG, CT-proAVP and H-FABP for the purposes of making diagnosis, their use as a guide of therapy or for determination of prognosis.

Early pharmacological treatment of acute heart failure syndromes: A systematic review of clinical trials

2007 ◽  
Vol 9 (1) ◽  
pp. 10-21 ◽  
Author(s):  
Leonardo De Luca ◽  
Gregg C. Fonarow ◽  
Alexandre Mebazaa ◽  
David D. Shin ◽  
Sean P. Collins ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Clinical Trials ◽  
Acute Heart Failure ◽  
Pharmacological Treatment ◽  
Acute Heart Failure Syndromes

620 Modifications of left atrial reservoir function early after acute heart failure

1999 ◽  
Vol 1 ◽  
pp. S103-S103
Author(s):  
M ALIMENTO ◽  
P BARBIER ◽  
A GRIMALDI ◽  
G BERNA ◽  
M GUAZZI
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Left Atrial ◽  
Reservoir Function

588 The prognostic role of anemia in acute heart failure. Data from the Italian survey on acute heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 134-134
Author(s):  
L SCELSI ◽  
L TAVAZZI ◽  
A MAGGIONI ◽  
D LUCCI ◽  
G CACCIATORE ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
Prognostic Role ◽  
Failure Data ◽  
Italian Survey
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