scholarly journals Sildenafil Increases Digital Skin Blood Flow During All Phases of Local Cooling in Primary Raynaud's Phenomenon

2012 ◽  
Vol 91 (5) ◽  
pp. 813-819 ◽  
Author(s):  
M Roustit ◽  
M Hellmann ◽  
C Cracowski ◽  
S Blaise ◽  
J L Cracowski
Keyword(s):  
Blood Flow ◽  
Skin Blood Flow ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Local Cooling ◽  
Primary Raynaud’S Phenomenon

Impaired transient vasodilation and increased vasoconstriction to digital local cooling in primary Raynaud's phenomenon

2011 ◽  
Vol 301 (2) ◽  
pp. H324-H330 ◽  
Author(s):  
Matthieu Roustit ◽  
Sophie Blaise ◽  
Claire Millet ◽  
Jean-Luc Cracowski
Keyword(s):  
Blood Flow ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Topical Anesthesia ◽  
Sensory Nerves ◽  
Local Cooling ◽  
Doppler Flowmetry ◽  
Percentage Decrease ◽  
Significant Difference ◽  
And Gender

Raynaud's phenomenon (RP) is defined as episodic ischemia of the extremities in response to cold. Although the structure of skin capillaries is normal in primary RP, some data suggest impairment of microvascular function. We aimed at testing whether digital skin blood flow was lower in RP than in controls while cooling locally. We further evaluated the contribution of sensory nerves in the response. We recruited 21 patients with primary RP and 20 healthy volunteers matched on age and gender. After a 10-min baseline at 33°C, skin temperature was cooled at 15 or 24°C during 30 min on the forearm and the finger while monitoring perfusion with a custom-design laser Doppler flowmetry probe. Perfusion was also assessed after topical anesthesia. Blood flow was expressed as cutaneous vascular conductance (CVC). Data were subsequently expressed as area above the curve (AAC0–30) of the percentage decrease from baseline CVC (%BL). CVC on the dorsum of the finger was lower in RP patients compared with controls at 15°C (AAC0–30 were 106,237.2 and 69,544.3%BL·s, respectively; P = 0.02) and at 24°C (AAC0–30 were 86,915 and 57,598%BL·s, respectively; P = 0.04) whereas we observed no significant difference on the finger pad and the forearm. Topical anesthesia increased CVC in patients with RP ( P = 0.05), whereas it did not affect reactivity in controls ( P = 0.86). Our study shows exaggerated skin microvascular vasoconstriction to local cooling on the dorsum of the finger in primary RP compared with controls. Part of this abnormal response in primary RP depends on sensitive nerves.

The effect of captopril on cutaneous blood flow in patients with primary Raynaud's phenomenon

1987 ◽  
Vol 117 (6) ◽  
pp. 751-758 ◽  
Author(s):  
M.H.A. RUSTIN ◽  
N.E. ALMOND ◽  
J.A. BEACHAM ◽  
R.J. BROOKS ◽  
D.P. JONES ◽  
...  
Keyword(s):  
Blood Flow ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Cutaneous Blood Flow ◽  
Primary Raynaud’S Phenomenon ◽  
Cutaneous Blood

scholarly journals “Beet” the cold: beetroot juice supplementation improves peripheral blood flow, endothelial function, and anti-inflammatory status in individuals with Raynaud’s phenomenon

2019 ◽  
Vol 127 (5) ◽  
pp. 1478-1490 ◽  
Author(s):  
Anthony I. Shepherd ◽  
Joseph T. Costello ◽  
Stephen J. Bailey ◽  
Nicolette Bishop ◽  
Alex J. Wadley ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Endothelial Function ◽  
Diastolic Blood Pressure ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Beetroot Juice ◽  
Local Cooling ◽  
Inflammatory Status ◽  
Anti Inflammatory

Raynaud’s phenomenon (RP) is characterized by recurrent transient peripheral vasospasm and lower nitric oxide (NO) bioavailability in the cold. We investigated the effect of nitrate-rich beetroot juice (BJ) supplementation on 1) NO-mediated vasodilation, 2) cutaneous vascular conductance (CVC) and skin temperature (Tsk) following local cooling, and 3) systemic anti-inflammatory status. Following baseline testing, 23 individuals with RP attended four times, in a double-blind, randomized crossover design, following acute and chronic (14 days) BJ and nitrate-depleted beetroot juice (NDBJ) supplementation. Peripheral Tsk and CVC were measured during and after mild hand and foot cooling, and during transdermal delivery of acetylcholine and sodium nitroprusside. Markers of anti-inflammatory status were also measured. Plasma nitrite concentration ([nitrite]) was increased in the BJ conditions ( P < 0.001). Compared with the baseline visit, thumb CVC was greater following chronic-BJ (Δ2.0 flux/mmHg, P = 0.02) and chronic-NDBJ (Δ1.45 flux/mmHg, P = 0.01) supplementation; however, no changes in Tsk were observed ( P > 0.05). Plasma [interleukin-10] was greater, pan endothelin and systolic and diastolic blood pressure (BP) were reduced, and forearm endothelial function was improved, by both BJ and NDBJ supplementation ( P < 0.05). Acute and chronic BJ and NDBJ supplementation improved anti-inflammatory status, endothelial function and blood pressure (BP). CVC following cooling increased post chronic-BJ and chronic-NDBJ supplementation, but no effect on Tsk was observed. The key findings are that beetroot supplementation improves thumb blood flow, improves endothelial function and anti-inflammatory status, and reduces BP in people with Raynaud’s. NEW & NOTEWORTHY This is the first study to examine the effect of dietary nitrate supplementation in individuals with Raynaud’s phenomenon. The principal novel findings from this study were that both beetroot juice and nitrate-depleted beetroot juice 1) increased blood flow in the thumb following a cold challenge; 2) enhanced endothelium-dependent and -independent vasodilation in the forearm; 3) reduced systolic and diastolic blood pressure, and pan-endothelin concentration; and 4) improved inflammatory status in comparison to baseline.

scholarly journals Laser Doppler Perfusion Imaging Is Useful in the Study of Raynaud’s Phenomenon and Improves the Capillaroscopic Diagnosis

2009 ◽  
Vol 36 (10) ◽  
pp. 2257-2263 ◽  
Author(s):  
EDOARDO ROSATO ◽  
FEDERICA BORGHESE ◽  
SIMONETTA PISARRI ◽  
FELICE SALSANO
Keyword(s):  
Blood Flow ◽  
Distribution Pattern ◽  
Skin Blood Flow ◽  
Perfusion Imaging ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Laser Doppler ◽  
Healthy Controls ◽  
Laser Doppler Perfusion Imaging ◽  
Distal Perfusion

Objective.To investigate capillary morphology and skin blood flow of dorsal hands by nailfold videocapillaroscopy (NVC) and laser Doppler perfusion imaging (LDPI), respectively, in patients with primary Raynaud’s phenomenon (PRP) and systemic sclerosis (SSc) and to compare the results with those obtained in healthy controls.Methods.The study group consisted of 142 patients with SSc, 88 patients with PRP, and 147 healthy controls. NVC was performed in all the groups examined. In patients with SSc the capillaroscopic pattern was classified as early, active, or late group pattern. A baseline skin blood flow determination of the dorsum of the subject’s hands was acquired through a low-energy 670 nm Lisca Laser Doppler Perfusion Imager.Results.In the healthy controls the perfusion distribution pattern was homogeneous, with a proximal-distal perfusion gradient. In patients with PRP, the perfusion distribution pattern was homogeneous, but the proximal-distal perfusion gradient was absent. Finally, in patients with SSc the perfusion distribution pattern was dyshomogeneous and a proximal-distal gradient was absent. The minimum perfusion, mean perfusion, maximum perfusion, and standard deviation, calculated as variation by means of each measurement site, were significantly different in all the groups examinated.Conclusion.NVC represents the best method to analyze microvascular damage in rheumatic diseases. LDPI improves the evaluation of vascular damage in patients with SSc. The LDPI and the capillaroscopic images fully matched the definition of the various stages of vascular digital damage in SSc.

scholarly journals Vasodilators for primary Raynaud's phenomenon

2021 ◽  
Author(s):  
Kevin YC Su ◽  
Meghna Sharma ◽  
Hyunjun Jonathan Kim ◽  
Elizabeth Kaganov ◽  
Ian Hughes ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Primary Raynaud’S Phenomenon

Primary Raynaud’s phenomenon and nailfold videocapillaroscopy: age-related changes in capillary morphology

2016 ◽  
Vol 36 (7) ◽  
pp. 1637-1642 ◽  
Author(s):  
Carmen Pizzorni ◽  
Alberto Sulli ◽  
Vanessa Smith ◽  
Barbara Ruaro ◽  
Amelia Chiara Trombetta ◽  
...  
Keyword(s):  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Nailfold Videocapillaroscopy ◽  
Age Related ◽  
Primary Raynaud’S Phenomenon ◽  
Age Related Changes
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