Monitoring for Hepatotoxicity: What Is the Predictive Value of Liver “Function” Tests?

2009 ◽  
Vol 85 (3) ◽  
pp. 331-334 ◽  
Author(s):  
JR Senior
Keyword(s):  
Liver Function ◽  
Predictive Value ◽  
Liver Function Tests ◽  
Function Tests

scholarly journals The Role of CEA and Liver Function Tests in the Detection of Hepatic Metastases From Colo-Rectal Cancer

HPB Surgery ◽  
1990 ◽  
Vol 3 (1) ◽  
pp. 29-37 ◽  
Author(s):  
G. Bonfanti ◽  
Luigia Bombelli ◽  
F. Bozzetti ◽  
R. Doci ◽  
L. Gennari ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Liver Function ◽  
Liver Metastases ◽  
Predictive Value ◽  
Imaging Technique ◽  
Hepatic Metastases ◽  
Liver Function Tests ◽  
Good Prediction ◽  
Gamma Glutamyl Transpeptidase ◽  
Function Tests

Carcinoembryonic antigen and some liver function tests (alkaline phosphatase, gamma-glutamyl-transpeptidase, lactic dehydrogenase and cholinesterase) were evaluated in patients with primary colorectal cancer in order to define their role in the pre-operative detection of liver metastases.The records of 278 consecutive patients admitted to the Istituto Nazionale Tumori of Milan between January 1982 and December 1983 who were suffering from primary invasive colo-rectal cancer and who underwent laparotomy were retrospectively analyzed.At laparotomy, liver metastases were found in 38 pts (13.7%). Considering single tests, CEA was the most sensitive (71%); no single test was found to be reliably predictive, when the result was abnormal. On the contrary, the normal value of each test was associated with a good prediction.When we considered all the five tests together in the single patient their predictive value, when abnormal, proved to be quite good only if four or five results were abnormal. On the other hand, liver metastases in the presence of all normal tests were found only in two patients, so giving a negative predictive value of about 97%.So we conclude that, in the lack of an infallable imaging technique for liver evaluation, in the presence of all normal tests any other investigation on the liver could be avoided. However, when liver tests are pathologic, some other imaging technique should be performed in order to supply the surgeon with information about the extent and the spread of the metastases.

ABNORMALITIES OF LIVER FUNCTION AND THE PREDICTIVE VALUE OF LIVER FUNCTION TESTS IN INFECTION AND OUTCOME OF ACUTELY ILL ELDERLY PATIENTS

1984 ◽  
Vol 13 (4) ◽  
pp. 224-229 ◽  
Author(s):  
ROSE ANNE M. KENNY ◽  
H. M. HODKINSON ◽  
OONAGH F. PRENDIVILLE ◽  
MARY C. HAYES ◽  
M. D. FLYNN
Keyword(s):  
Liver Function ◽  
Elderly Patients ◽  
Predictive Value ◽  
Liver Function Tests ◽  
Function Tests

Relevance of liver function tests in pulmonary hypertension

2014 ◽  
Vol 52 (08) ◽  
Author(s):  
KC Grotemeyer ◽  
H Wilkens ◽  
F Lammert ◽  
R Bals ◽  
R Kaiser
Keyword(s):  
Pulmonary Hypertension ◽  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests
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