Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist

Alain Munafo; Yves Christen; Jürg Nussberger; Linyee Y Shum; R Michael Borland; Robert J Lee; Bernard Waeber; Jérôme Biollaz; Hans R Brunner

doi:10.1038/clpt.1992.56

Drug concentration response relationships in normal volunteers after oral administration of losartan, an angiotensin II receptor antagonist

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.1992.56 ◽

1992 ◽

Vol 51 (5) ◽

pp. 513-521 ◽

Cited By ~ 133

Author(s):

Alain Munafo ◽

Yves Christen ◽

Jürg Nussberger ◽

Linyee Y Shum ◽

R Michael Borland ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Drug Concentration ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Normal Volunteers

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Phase I Study of MK-954, a New Angiotensin II Receptor Antagonist. Results of Single Oral Administration.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ◽

10.3999/jscpt.26.671 ◽

1995 ◽

Vol 26 (3) ◽

pp. 671-684 ◽

Cited By ~ 3

Author(s):

Mitsuyoshi NAKASHIMA ◽

Mitsutaka KANAMARU ◽

Toshihiko UEMATSU ◽

Fumio TAKAYAMA ◽

Kazuo KAMEI

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Phase I ◽

Receptor Antagonist ◽

Phase I Study ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Single Oral Administration

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SC-52458, an Orally Active Angiotensin II-Receptor Antagonist: Inhibition of Blood Pressure Response to Angiotensin II Challenges and Pharmacokinetics in Normal Volunteers

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199704000-00003 ◽

1997 ◽

Vol 29 (4) ◽

pp. 444-450 ◽

Cited By ~ 7

Author(s):

M. Hagmann ◽

J. Nussberger ◽

R. B. Naudin ◽

T. S. Burns ◽

A. Karim ◽

...

Keyword(s):

Blood Pressure ◽

Angiotensin Ii ◽

Receptor Antagonist ◽

Blood Pressure Response ◽

Pressure Response ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Normal Volunteers ◽

Orally Active

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Pharmacological Profiles of a Highly Potent and Long-Acting Angiotensin II Receptor Antagonist, Fimasartan, in Rats and Dogs after Oral Administration

Biological and Pharmaceutical Bulletin ◽

10.1248/bpb.b16-00987 ◽

2017 ◽

Vol 40 (7) ◽

pp. 992-1001 ◽

Cited By ~ 3

Author(s):

Soo Heui Paik ◽

Yong Ha Chi ◽

Joo Han Lee ◽

Hee-Soo Han ◽

Kyung-Tae Lee

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Long Acting ◽

Pharmacological Profiles

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Antihypertensive effects of acute and chronic oral administration of KT3-671, a novel angiotensin II receptor antagonist, in renal hypertensive dogs.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)37529-8 ◽

1996 ◽

Vol 71 ◽

pp. 322

Author(s):

Shingo Tajima ◽

Yoshinobu Takata ◽

Hitoshi Kato

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Oral administration of DuP 753, a specific angiotensin II receptor antagonist, to normal male volunteers. Inhibition of pressor response to exogenous angiotensin I and II.

Circulation ◽

10.1161/01.cir.83.4.1333 ◽

1991 ◽

Vol 83 (4) ◽

pp. 1333-1342 ◽

Cited By ~ 163

Author(s):

Y Christen ◽

B Waeber ◽

J Nussberger ◽

M Porchet ◽

R M Borland ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Pressor Response ◽

Normal Male ◽

Angiotensin Ii Receptor ◽

Angiotensin I ◽

Angiotensin Ii Receptor Antagonist ◽

Male Volunteers

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Phase I Study of MK-954, a New Angiotensin II Receptor Antagonist. Results of Multiple Oral Administration.

Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ◽

10.3999/jscpt.26.685 ◽

1995 ◽

Vol 26 (3) ◽

pp. 685-696

Author(s):

Mitsuyoshi NAKASHIMA ◽

Mitsutaka KANAMARU ◽

Toshihiko UEMATSU ◽

Fumio TAKAYAMA ◽

Kazuo KAMEI

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Phase I ◽

Receptor Antagonist ◽

Phase I Study ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Metabolic Fate of Losartan, a New Angiotensin II Receptor Antagonist. (2). Absorption, Distribution, Metabolism, Excretion and Effects on Drug Metabolizing Enzyme Activities after Repeated Oral Administration in Rats.

Drug Metabolism and Pharmacokinetics ◽

10.2133/dmpk.10.244 ◽

1995 ◽

Vol 10 (2) ◽

pp. 244-256 ◽

Cited By ~ 2

Author(s):

Fumio TAKAYAMA ◽

Hiroyuki ISHIZAKI ◽

Tomomi YOSHINAGA ◽

Mitsuko MORITA ◽

Shunsuke HATA ◽

...

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Enzyme Activities ◽

Angiotensin Ii Receptor ◽

Metabolic Fate ◽

Angiotensin Ii Receptor Antagonist ◽

Drug Metabolizing Enzyme ◽

Metabolizing Enzyme

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Pharmacokinetics and biochemical efficacy after single and multiple oral administration of losartan, an orally active nonpeptide angiotensin II receptor antagonist, in humans.

British Journal of Clinical Pharmacology ◽

10.1111/j.1365-2125.1993.tb05696.x ◽

1993 ◽

Vol 35 (3) ◽

pp. 290-297 ◽

Cited By ~ 106

Author(s):

M. Ohtawa ◽

F. Takayama ◽

K. Saitoh ◽

T. Yoshinaga ◽

M. Nakashima

Keyword(s):

Angiotensin Ii ◽

Oral Administration ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist ◽

Orally Active

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Chronic hemodynamic and antifibrotic effects of a specific angiotensin II receptor antagonist (losartan) in bile duct ligated (BDL) rats and in portal vein ligated (PVL) rats

Journal of Hepatology ◽

10.1016/s0168-8278(01)80311-1 ◽

2001 ◽

Vol 34 (0) ◽

pp. 88

Author(s):

V Croquet

Keyword(s):

Angiotensin Ii ◽

Bile Duct ◽

Portal Vein ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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Angiotensin II Receptor Antagonist Improves the Immune Activations of Patients With Chronic Heart Failure

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)83860-0 ◽

1998 ◽

Vol 31 (2) ◽

pp. 33A

Author(s):

T Tsutamoto

Keyword(s):

Heart Failure ◽

Angiotensin Ii ◽

Chronic Heart Failure ◽

Receptor Antagonist ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonist

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