The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose

1989 ◽  
Vol 46 (4) ◽  
pp. 408-419 ◽  
Author(s):  
Rebecca A Boyd ◽  
Shu K Chin ◽  
Oluta Don-Pedro ◽  
Davide Verotta ◽  
Lewis B Sheiner ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Healthy Adults ◽  
Pharmacokinetics And Pharmacodynamics

Pharmacokinetics and Pharmacodynamics of Amoxicillin-Sulbactam, a Novel Aminopenicillin–β-Lactamase Inhibitor Combination, against Escherichia coli

1999 ◽  
Vol 43 (6) ◽  
pp. 1503-1504 ◽  
Author(s):  
Carlos Bantar ◽  
Federico Nicola ◽  
Hector J. Arenoso ◽  
Marcelo Galas ◽  
Liliana Soria ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Oral Dose ◽  
Single Oral Dose ◽  
Drug Combination ◽  
Pharmacokinetics And Pharmacodynamics ◽  
E Coli ◽  
Inhibitory Activities ◽  
Novel Drug ◽  
Inhibitor Combination ◽  
Lactamase Inhibitor

ABSTRACT We evaluated the pharmacokinetics of amoxicillin-sulbactam (AMX-SUL), a novel drug combination, and its pharmacodynamics againstEscherichia coli in 12 volunteers receiving a single oral dose (1,000 mg). Peak serum bactericidal and urine inhibitory activities in most volunteers were observed against E. colistrains for which AMX-SUL MICs were low (2- to 4-mg/liter) (2 strains) and high (≥16-mg/liter) (47 strains), respectively.

Effect of itraconazole on the single oral dose pharmacokinetics and pharmacodynamics of alprazolam

1998 ◽  
Vol 139 (3) ◽  
pp. 269-273 ◽  
Author(s):  
Norio Yasui ◽  
T. Kondo ◽  
Koichi Otani ◽  
Hanako Furukori ◽  
Sunao Kaneko ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics

scholarly journals Vitamin B12 Absorption as Measured by Total B12 and Holo-TC Following A Single Oral Dose of Multivitamin in Healthy Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1332-1332
Author(s):  
Kelly Zhang ◽  
William Hooper ◽  
Laura Harkness ◽  
Annahita Ghassemi
Keyword(s):  
Oral Dose ◽  
Vitamin B12 ◽  
Single Oral Dose ◽  
Phase 1 ◽  
Healthy Adults ◽  
Serum Samples ◽  
Funding Sources ◽  
Significant Difference ◽  
Vitamin B12 Absorption ◽  
The Difference

Abstract Objectives Measure total B12 and holotranscobalamin (Holo-TC) concentrations in serum to show vitamin B12 absorption following single oral doses of multivitamin (MVI) gummy and tablet. Methods This crossover clinical trial involved healthy adults randomized to either gummy or tablet multivitamins (MVI) containing vitamin B12 (60.8 mcg in gummy and 91.8 mcg in tablet) as cyanocobalamin in a single dose in Phase 1 with serial blood samples collected at pre-dose and at 0.5-, 1-, 2-, 4-, 6-, 8-, 9-, 10-, 24-, and 48-hrs after dosing, followed by a 2-week washout period. In Phase 2, participants then crossed over to receive MVI in the form not previously given, with blood draws at the same timepoints. Serum samples were measured for total B12 (n = 19) using an electrochemiluminescence immunoassay (ECLIA) and for Holo-TC (n = 14) using commercial Holo-TC ELISA kit. Measurements from groups of time points were averaged to estimate pre-absorptive (0 to 2 hours) and absorptive (6 to 10 hours) concentrations of total B12 and Holo-TC for each subject. The difference between pre-absorptive and absorptive concentrations for both analytes was calculated to estimate newly absorbed vitamin B12. Results Mean increases of about 15% in serum Holo-TC in absorptive phase over the pre-absorptive phase were observed for both the gummies and the tablets, which are statistically significant (p < 0.001). These changes were similar to those observed for total B12. There was no significant difference in mean increases between the gummies and the tablets in both total B12 and Holo-TC. These results support the conclusion that the observed increases in total B12 and Holo-TC were the result of intestinal absorption following the single oral dose. Conclusions Overall, under the conditions of this study, both gummy and tablet multivitamins showed similar absorption of vitamin B12, whether assessed by total B12 or holo-TC measurement. Funding Sources Church & Dwight Co. Inc.

No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam

2002 ◽  
Vol 24 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Yohei Otsuji ◽  
Naoyuki Okuyama ◽  
Toshiaki Aoshima ◽  
Takashi Fukasawa ◽  
Kimiyasu Kato ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics

Effect of Food on the Pharmacokinetics and Pharmacodynamics of a Single Oral Dose of Tegoprazan

2021 ◽  
Author(s):  
Sungpil Han ◽  
Hee Youn Choi ◽  
Yo Han Kim ◽  
Ji Yeon Nam ◽  
Bongtae Kim ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Effect Of Food

Pharmacokinetics and Pharmacodynamics of Tepoxalin after Single Oral Dose Administration to Healthy Volunteers

1996 ◽  
Vol 36 (5) ◽  
pp. 462-468 ◽  
Author(s):  
Scott A. Waldman ◽  
Cheryl Vitow ◽  
Barbara Osborne ◽  
Lisa Gillen ◽  
Dennis C. Argentieri ◽  
...  
Keyword(s):  
Oral Dose ◽  
Healthy Volunteers ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Dose Administration

scholarly journals Pharmacokinetics and pharmacodynamics after administration of a single oral dose of aprindine hydrochloride.

1985 ◽  
Vol 16 (2) ◽  
pp. 417-425 ◽  
Author(s):  
Mitsuhiro YOKOTA ◽  
Kazuaki MIYAHARA ◽  
Iwao SOTOBATA ◽  
Jitsuki TSUZUKI ◽  
Junki GOTO ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Pharmacokinetics And Pharmacodynamics
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