The acute effects of acrivastine (BW825C), a new antihistamine, compared with triprolidine on measures of central nervous system performance and subjective effects

1985 ◽  
Vol 38 (4) ◽  
pp. 381-386 ◽  
Author(s):  
A F Cohen ◽  
M Hamilton ◽  
R Philipson ◽  
A W Peck
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
System Performance ◽  
Subjective Effects ◽  
Acute Effects

scholarly journals Chronic and acute effects of solvents on central nervous system functions in floorlayers.

1986 ◽  
Vol 43 (2) ◽  
pp. 101-106 ◽  
Author(s):  
K Ekberg ◽  
L Barregard ◽  
S Hagberg ◽  
G Sallsten
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Effects

Acute effects of 1,1,1-trichloroethane inhalation on the human central nervous system

1996 ◽  
Vol 69 (1) ◽  
pp. 53-61 ◽  
Author(s):  
A. Laine ◽  
Anna Maria Sepp�l�inen ◽  
Kai Savolainen ◽  
Vesa Riihim�ki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Effects ◽  
Human Central Nervous System

Acute Effects of Central Neuropeptide Y Injection on Glucose Metabolism in Fasted Rats

1995 ◽  
Vol 89 (5) ◽  
pp. 543-548 ◽  
Author(s):  
J. P. H. Wilding ◽  
Y. T. Kruszynska ◽  
P. D. Lambert ◽  
S. R. Bloom
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Glucose Metabolism ◽  
Neuropeptide Y ◽  
Plasma Glucose ◽  
Hepatic Glucose Production ◽  
Constant Infusion ◽  
Initial Increase ◽  
Acute Effects ◽  
Fasted Rats

1. Neuropeptide Y is a potent appetite stimulant and has been found to modulate glucose metabolism when given chronically. The acute effects of neuropeptide on peripheral glucose handling have not been studied in detail. We have studied the acute effects of central nervous system injection of neuropeptide on glucose metabolism in vivo in the rat. 2. Rats implanted with chronic cannulae in the third cerebral ventricle were injected with either neuropeptide Y or saline and peripheral insulin sensitivity was assessed during a hyperinsulinaemic euglycaemic clamp. The effect of centrally injected neuropeptide Y on post-absorptive glucose metabolism was studied using a constant infusion of [6-3H]glucose. 3. Infusion of neuropeptide Y resulted in a 18% increase in glucose requirement during the clamp, suggesting increased peripheral tissue responsiveness to insulin. Neuropeptide Y injection in 10 h fasted rats increased plasma glucose (area under curve 9.9 ± 0.2 versus 9.1 ± 0.1 mmol h−1 I−1, P < 0.01), insulin (103 ± 23 versus 33 ± 8 pmol/l, P < 0.01, at 30 min) and glucagon (5.5 ± 0.5 versus 3.1 ± 0.3 pmol/l, P < 0.05, at 30 min). The increase in plasma glucose was due to an initial increase in the rate of appearance, which peaked between 20 and 30 min after neuropeptide Y infusion; over the entire 90 min 16% more glucose entered the systemic circulation in the neuropeptide Y-treated rats than in control rats, and the total quantity of glucose removed was also greater. 4. Neuropeptide Y in the central nervous system influences glucose metabolism by altering secretion of islet hormones, hepatic glucose production and the peripheral response to insulin.

Central nervous system catecholamine content and norepinephrine release after AV3V ablation

1992 ◽  
Vol 262 (6) ◽  
pp. R1064-R1069 ◽  
Author(s):  
J. W. Van Huysse ◽  
S. L. Bealer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Ventricle ◽  
Hypothalamic Nucleus ◽  
Acute Effects ◽  
Norepinephrine Release ◽  
Paraventricular Hypothalamic Nucleus ◽  
Catecholamine Content ◽  
Electrolytic Ablation ◽  
The Brain

Electrolytic ablation of the periventricular tissue surrounding the anteroventral third cerebral ventricle (AV3V-X) results in immediate increases in norepinephrine release in the paraventricular hypothalamic nucleus/anterior hypothalamus (P/A) and in the dorsomedial medulla (DM) and depletion of norepinephrine and epinephrine throughout the brain. The present study determined whether catecholamine depletion and/or altered norepinephrine release persisted after recovery from the acute effects of AV3V-X. Fourteen to eighteen days after surgery, catecholamine concentrations throughout the brain and norepinephrine release in the P/A and DM during hemorrhage were measured in control-operated and AV3V-X rats. AV3V-X decreased epinephrine content only in the midbrain, increased norepinephrine only in the cortex, and produced no differences in central nervous system dopamine. Hemorrhage-induced norepinephrine release was significantly greater in the P/A of AV3V-X rats than in control animals, whereas norepinephrine release in the DM increased equally in both groups. Thus AV3V-X does not result in chronic global central nervous system catecholamine depletion and enhances norepinephrine release in the P/A during hemorrhage.

Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment

2002 ◽  
Vol 16 (4) ◽  
pp. 337-343 ◽  
Author(s):  
J. Van der Post ◽  
L. A. W. Noordzij ◽  
M. L. de Kam ◽  
G. J. Blauw ◽  
A. F. Cohen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cognitive Impairment ◽  
System Performance

Acute effects of 1,1,1-trichloroethane inhalation on the human central nervous system

1996 ◽  
Vol 69 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Arto Laine ◽  
Anna Maria Seppäläinen ◽  
Kai Savolainen ◽  
Vesa Riihimäki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Acute Effects ◽  
Human Central Nervous System

scholarly journals Functional biomarkers for the acute effects of alcohol on the central nervous system in healthy volunteers

2011 ◽  
Vol 71 (3) ◽  
pp. 331-350 ◽  
Author(s):  
Remco W. M. Zoethout ◽  
Wilson L. Delgado ◽  
Annelies E. Ippel ◽  
Albert Dahan ◽  
Joop M. A. van Gerven
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Healthy Volunteers ◽  
Acute Effects ◽  
The Central Nervous System ◽  
Functional Biomarkers
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