Effects of amiloride on plasma and total body potassium, blood pressure, and the renin-angiotensin-aldosterone system in thiazide-treated hypertensive patients

1983 ◽  
Vol 34 (4) ◽  
pp. 448-453 ◽  
Author(s):  
Ulrik Gerner Svendsen ◽  
Hans Ibsen ◽  
Sten Rasmussen ◽  
Arne Leth ◽  
Meta Damkjær Nielsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Total Body Potassium ◽  
Renin Angiotensin Aldosterone System ◽  
Hypertensive Patients ◽  
Renin Angiotensin ◽  
Total Body

scholarly journals TOTAL BODY POTASSIUM IN LOW RENIN ESSENTIAL HYPERTENSION WITH REFERENCE TO THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

1978 ◽  
Vol 67 (12) ◽  
pp. 1522-1528
Author(s):  
Shin SUZUKI ◽  
Yutaka DOI ◽  
Shunsuke TASAKI ◽  
Wataru AOI ◽  
Morio KURAMOCHI ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Total Body Potassium ◽  
Renin Angiotensin Aldosterone System ◽  
Renin Angiotensin ◽  
Total Body

scholarly journals Effect of captopril on blood pressure and renin-angiotensin-aldosterone system in hypertensive patients on hemodialysis.

1982 ◽  
Vol 137 (1) ◽  
pp. 21-31 ◽  
Author(s):  
HIROSHI KANEDA ◽  
TOYOAKI MURATA ◽  
JUN MATSUMOTO ◽  
TAKAKICHI MAETA ◽  
KOZO SHITOMI ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renin Angiotensin Aldosterone System ◽  
Hypertensive Patients ◽  
Renin Angiotensin

scholarly journals SUN-LB94 Impact of the Gut Microbiome and Renin-Angiotensin-Aldosterone System in Hypertensive Patients With Low-Salt Intake

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Kouki Taniguchi ◽  
Satoshi Nagase ◽  
Shigehiro Karashima ◽  
Mitsuhiro Kometani ◽  
Daisuke Aono ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Gut Microbiome ◽  
Salt Intake ◽  
High Salt ◽  
Renin Angiotensin Aldosterone System ◽  
Hypertensive Patients ◽  
Renin Angiotensin ◽  
High Salt Intake ◽  
Low Salt ◽  
The Impact

Abstract Salt intake is one of most important environmental factors responsible for triggering the onset of hypertension. Renin-angiotensin-aldosterone system (RAAS) plays a key role in adjusting sodium homeostasis and blood pressure. Recently, the potential role of the gut microbiome (GM) in altering the health of the host has drawn considerable attention. We investigated the impact of intestinal microflora and RAAS in hypertensive patients with low-salt or high-salt intake using an observational study. A total of 239 participants were enrolled and their GMs and clinical backgrounds examined, including the renin-angiotensin-aldosterone system and inflammatory cytokine levels. On the basis of enterotypes—determined by cluster analysis—and salt intake, the participants were classified into four groups, low salt/GM enterotype 1, low salt/GM enterotype 2, high salt/GM enterotype 1, and high salt/GM enterotype 2. The prevalence of hypertension was significantly lower in the low-salt intake (low salt/GM enterotype 1 = 47% vs low salt/GM enterotype 2 = 27%, p = 0.04) groups. No significant difference in the prevalence of hypertension was observed for the two GM enterotype groups with high-salt intake (GM enterotype 1 = 50%, GM enterotype 2 = 47%; p = 0.83). Plasma aldosterone concentration was significantly different among the four groups (p < 0.01). Furthermore, the relative abundance of Blautia, Bifidobacterium, Escherichia-Shigella, Lachnoclostridium, and Clostridium sensu stricto was also significantly different among these enterotypes. This suggested in certain individuals (with specific gut bacteria composition) changing dietary habits—to low salt—would be ineffective for regulating hypertension through RAAS. Our findings provide a new strategy for controlling blood pressure and preventing the development of hypertension through restoring GM homeostasis.

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