scholarly journals Let-7c blocks estrogen-activated Wnt signaling in induction of self-renewal of breast cancer stem cells

2016 ◽  
Vol 23 (4) ◽  
pp. 83-89 ◽  
Author(s):  
X Sun ◽  
C Xu ◽  
S-C Tang ◽  
J Wang ◽  
H Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Breast Cancer Stem Cells ◽  
Self Renewal

scholarly journals Targeting the Roots of Recurrence: New Strategies for Eliminating Therapy-Resistant Breast Cancer Stem Cells

Cancers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 54
Author(s):  
Margaret L. Dahn ◽  
Paola Marcato
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Self Renewal ◽  
New Strategies

Cancer stem cells (CSCs) are functionally defined in our laboratories by their impressive tumor-generating and self-renewal capacity; clinically, CSCs are of interest because of their enhanced capacity to evade conventional therapies [...]

scholarly journals The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells

2010 ◽  
Vol 126 (2) ◽  
pp. 355-364 ◽  
Author(s):  
Alejandro Vazquez-Martin ◽  
Cristina Oliveras-Ferraros ◽  
Sonia Del Barco ◽  
Begoña Martin-Castillo ◽  
Javier A. Menendez
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Self Renewal

scholarly journals Loss of SIRT4 promotes the self-renewal of Breast Cancer Stem Cells

Theranostics ◽  
2020 ◽  
Vol 10 (21) ◽  
pp. 9458-9476 ◽  
Author(s):  
Lutao Du ◽  
Xiaoyan Liu ◽  
Yidan Ren ◽  
Juan Li ◽  
Peilong Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
The Self ◽  
Breast Cancer Stem Cells ◽  
Self Renewal

scholarly journals miR‐10b expression in breast cancer stem cells supports self‐renewal through negative PTEN regulation and sustained AKT activation

EMBO Reports ◽  
2016 ◽  
Vol 17 (7) ◽  
pp. 1081-1081 ◽  
Author(s):  
Ivan Bahena‐Ocampo ◽  
Magali Espinosa ◽  
Gisela Ceballos‐Cancino ◽  
Floria Lizarraga ◽  
Denise Campos‐Arroyo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Breast Cancer Stem Cells ◽  
Self Renewal ◽  
Akt Activation

scholarly journals Cyclohexylmethyl Flavonoids Suppress Propagation of Breast Cancer Stem Cells via Downregulation of NANOG

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Wen-Ying Liao ◽  
Chih-Chuang Liaw ◽  
Yuan-Chao Huang ◽  
Hsin-Ying Han ◽  
Hung-Wei Hsu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Suppressive Effect ◽  
Breast Cancer Stem Cells ◽  
Self Renewal ◽  
Breast Cscs ◽  
P53 Activation ◽  
Poorly Differentiated ◽  
Mcf 7

Breast cancer stem cells (CSCs) are highly tumorigenic and possess the capacity to self-renew. Recent studies indicated that pluripotent geneNANOGinvolves in regulating self-renewal of breast CSCs, and expression of NANOG is correlated with aggressiveness of poorly differentiated breast cancer. We initially confirmed that breast cancer MCF-7 cells expressed NANOG, and overexpression of NANOG enhanced the tumorigenicity of MCF-7 cells and promoted the self-renewal expansion of CD24−/lowCD44+CSC subpopulation. In contrast, knockdown of NANOG significantly affected the growth of breast CSCs. Utilizing flow cytometry, we identified five cyclohexylmethyl flavonoids that can inhibit propagation of NANOG-positive cells in both breast cancer MCF-7 and MDA-MB231 cells. Among these flavonoids, ugonins J and K were found to be able to induce apoptosis in non-CSC populations and to reduce self-renewal growth of CD24−/lowCD44+CSC population. Treatment with ugonin J significantly reduced the tumorigenicity of MCF-7 cells and efficiently suppressed formation of mammospheres. This suppression was possibly due to p53 activation and NANOG reduction as either addition of p53 inhibitor or overexpression of NANOG can counteract the suppressive effect of ugonin J. We therefore conclude that cyclohexylmethyl flavonoids can possibly be utilized to suppress the propagation of breast CSCs via reduction of NANOG.

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