scholarly journals Lenalidomide enhances the function of chimeric antigen receptor T cells against the epidermal growth factor receptor variant III by enhancing immune synapses

2015 ◽  
Vol 22 (10) ◽  
pp. 487-495 ◽  
Author(s):  
S Kuramitsu ◽  
M Ohno ◽  
F Ohka ◽  
S Shiina ◽  
A Yamamichi ◽  
...  
Keyword(s):  
T Cells ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chimeric Antigen Receptor ◽  
Antigen Receptor ◽  
Growth Factor Receptor ◽  
Immune Synapses ◽  
Epidermal Growth

scholarly journals Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

2015 ◽  
Vol 33 (15) ◽  
pp. 1688-1696 ◽  
Author(s):  
Nabil Ahmed ◽  
Vita S. Brawley ◽  
Meenakshi Hegde ◽  
Catherine Robertson ◽  
Alexia Ghazi ◽  
...  
Keyword(s):  
T Cells ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chimeric Antigen Receptor ◽  
Growth Factor Receptor ◽  
Her2 Positive ◽  
Car T Cells ◽  
Car T ◽  
Epidermal Growth

Purpose The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. Patients and Methods We conducted a phase I/II clinical study in which patients with recurrent/refractory human epidermal growth factor receptor 2 (HER2) –positive sarcoma received escalating doses (1 × 104/m2 to 1 × 108/m2) of T cells expressing an HER2-specific chimeric antigen receptor with a CD28.ζ signaling domain (HER2-CAR T cells). Results We enrolled 19 patients with HER2-positive tumors (16 osteosarcomas, one Ewing sarcoma, one primitive neuroectodermal tumor, and one desmoplastic small round cell tumor). HER2-CAR T-cell infusions were well tolerated with no dose-limiting toxicity. At dose level 3 (1 × 105/m2) and above, we detected HER2-CAR T cells 3 hours after infusion by quantitative polymerase chain reaction in 14 of 16 patients. HER2-CAR T cells persisted for at least 6 weeks in seven of the nine evaluable patients who received greater than 1 × 106/m2 HER2-CAR T cells (P = .005). HER2-CAR T cells were detected at tumor sites of two of two patients examined. Of 17 evaluable patients, four had stable disease for 12 weeks to 14 months. Three of these patients had their tumor removed, with one showing ≥ 90% necrosis. The median overall survival of all 19 infused patients was 10.3 months (range, 5.1 to 29.1 months). Conclusion This first evaluation of the safety and efficacy of HER2-CAR T cells in patients with cancer shows the cells can persist for 6 weeks without evident toxicities, setting the stage for studies that combine HER2-CAR T cells with other immunomodulatory approaches to enhance their expansion and persistence.

T cells are crucial for the anti-metastatic effect of anti-epidermal growth factor receptor antibodies

2007 ◽  
Vol 56 (11) ◽  
pp. 1701-1710 ◽  
Author(s):  
Greta Garrido ◽  
Pablo Lorenzano ◽  
Belinda Sánchez ◽  
Irene Beausoleil ◽  
Daniel F. Alonso ◽  
...  
Keyword(s):  
T Cells ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Receptor Antibodies
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