scholarly journals Enhanced specificity of HPV16 E6E7 siRNA by RNA–DNA chimera modification

2011 ◽  
Vol 18 (8) ◽  
pp. 587-597 ◽  
Author(s):  
K Yamato ◽  
N Egawa ◽  
S Endo ◽  
K Ui-Tei ◽  
T Yamada ◽  
...  
Keyword(s):  
Dna Chimera

Detection of Antigens Using a Protein–DNA Chimera Developed by Enzymatic Covalent Bonding with phiX Gene A*

2012 ◽  
Vol 84 (11) ◽  
pp. 5040-5046 ◽  
Author(s):  
Farhima Akter ◽  
Masayasu Mie ◽  
Sebastian Grimm ◽  
Per-Åke Nygren ◽  
Eiry Kobatake
Keyword(s):  
Covalent Bonding ◽  
Dna Chimera

scholarly journals N-Benzoyl-protected Peptide Nucleic Acid (PNA) Monomers Expand the Range of Nucleobases Available for PNA-DNA Chimera

2019 ◽  
Vol 48 (4) ◽  
pp. 341-344
Author(s):  
Masahito Inagaki ◽  
Ryohei Uematsu ◽  
Tatsuya Mizutani ◽  
Daisuke Unabara ◽  
Yasuyuki Araki ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Peptide Nucleic Acid ◽  
Dna Chimera

TARGETING OF A701G NUCLEOTIDE AT THE HUMAN ATP1A1 LOCUS USING A RNA/DNA CHIMERA

2002 ◽  
Vol 21 (11-12) ◽  
pp. 775-784
Author(s):  
Tiziana Cervelli ◽  
Grazia Lombardi ◽  
Lorenzo Citti ◽  
Alvaro Galli ◽  
Maria Teresa Locci ◽  
...  
Keyword(s):  
Dna Chimera

scholarly journals Synthesis of Peptide Ribonucleic Acid (PRNA)-DNA Chimera and Interaction with DNA and RNA

2007 ◽  
Vol 51 (1) ◽  
pp. 21-22 ◽  
Author(s):  
T. Wada ◽  
Y. Maeda ◽  
N. Sawa ◽  
H. Sato ◽  
H. Chon ◽  
...  
Keyword(s):  
Ribonucleic Acid ◽  
Dna And Rna ◽  
Dna Chimera

scholarly journals Transcription Factor Decoy Molecules Based on a Peptide Nucleic Acid (PNA)-DNA Chimera Mimicking Sp1 Binding Sites

2002 ◽  
Vol 278 (9) ◽  
pp. 7500-7509 ◽  
Author(s):  
Monica Borgatti ◽  
Ilaria Lampronti ◽  
Alessandra Romanelli ◽  
Carlo Pedone ◽  
Michele Saviano ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nucleic Acid ◽  
Binding Sites ◽  
Peptide Nucleic Acid ◽  
Transcription Factor Decoy ◽  
Dna Chimera

Automated Chemical Synthesis of PNA and PNA-DNA Chimera on a Nucleic Acid Synthesizer

1997 ◽  
Vol 16 (7-9) ◽  
pp. 1653-1656 ◽  
Author(s):  
Ravi Vinayak ◽  
Alexander C. van der Laan ◽  
Rick Brill ◽  
Ken Otteson ◽  
Alex Andrus ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Chemical Synthesis ◽  
Dna Chimera

scholarly journals Bile Acid Conjugated DNA Chimera that Conditionally Inhibits Carbonic Anhydrase-II in the Presence of MicroRNA-21

2015 ◽  
Vol 26 (8) ◽  
pp. 1606-1612 ◽  
Author(s):  
Xiaozhu Chu ◽  
Cooper H. Battle ◽  
Nan Zhang ◽  
Gyan H. Aryal ◽  
Madhusoodanan Mottamal ◽  
...  
Keyword(s):  
Bile Acid ◽  
Carbonic Anhydrase ◽  
Carbonic Anhydrase Ii ◽  
Dna Chimera

scholarly journals Decoy approach using RNA-DNA chimera oligonucleotides to inhibit the regulatory function of human immunodeficiency virus type 1 Rev protein.

1997 ◽  
Vol 41 (2) ◽  
pp. 319-325 ◽  
Author(s):  
T Nakaya ◽  
S Iwai ◽  
K Fujinaga ◽  
Y Sato ◽  
E Otsuka ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Regulatory Function ◽  
Immunodeficiency Virus ◽  
Bubble Structure ◽  
Hiv 1 ◽  
Dna Chimera ◽  
Rev Protein

Human immunodeficiency virus type 1 (HIV-1) encodes two regulatory proteins, Tat and Rev, that bind to target RNA sequences. These are the trans-activation responsive (TAR) RNA and the Rev-responsive element (RRE), respectively. The Rev protein shifts RNA synthesis to viral transcripts by binding to the RRE within the env gene. In the present study we prepared a RNA-DNA chimera consisting of 29 or 31 nucleotides to inhibit the Rev regulatory function by means of the decoy approach. The chimera oligonucleotides (anti-Rev oligonucleotides [AROs]) contained an RNA "bubble" structure (13 oligonucleotides; the Rev-binding element in RRE) that bound Rev with a high affinity in an in vitro assay. The controls were RNA-DNA chimera oligonucleotides (negative control oligonucleotides [NCOs]) similar to ARO, but without the bubble structure, that bound with considerably less affinity to Rev. When the inhibitory effects of these decoys on HIV-1 replication were examined, we found that AROs, but no NCOs, reduced more than 90% of the HIV-1 production generated by productively infected human T-cell lines. The production of primary HIV-1 isolates in healthy donor-derived peripheral blood mononuclear cells was also similarly inhibited by AROs. In addition, the induction of viral mRNAs and antigens in latently HIV-1-infected ACH-2 cells by tumor necrosis factor alpha was specifically inhibited by AROs, but not by NCOs. No apparent cytotoxicity was caused by either decoy. Thus, the use of a Rev-binding element-based decoy, the RNA-DNA chimera oligonucleotide, may represent a safer approach to gene therapy for reducing the virus load in HIV-1-infected individuals.

scholarly journals Artificial Modulation of the Gating Behavior of a K+ Channel in a KvAP-DNA Chimera

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e18598 ◽  
Author(s):  
Andrew Wang ◽  
Giovanni Zocchi
Keyword(s):  
K Channel ◽  
Dna Chimera
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