scholarly journals Combination of vorinostat and adenovirus-TRAIL exhibits a synergistic antitumor effect by increasing transduction and transcription of TRAIL in lung cancer cells

2011 ◽  
Vol 18 (7) ◽  
pp. 467-477 ◽  
Author(s):  
D R Kim ◽  
M-Y Park ◽  
C-S Lee ◽  
S-H Shim ◽  
H-I Yoon ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Lung Cancer Cells ◽  
Synergistic Antitumor Effect

Synergistic Antitumor Effect of Taxanes and CDK4/6 Inhibitor in Lung Cancer Cells and Mice Harboring KRAS Mutations

2021 ◽  
Vol 41 (10) ◽  
pp. 4807-4820
Author(s):  
KYOUNG-HWA SON ◽  
MIN-YOUNG KIM ◽  
JUNG-YOUNG SHIN ◽  
JEONG-OH KIM ◽  
JIN-HYOUNG KANG
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Lung Cancer Cells ◽  
Kras Mutations ◽  
Synergistic Antitumor Effect

scholarly journals The Synergistic Antitumor Effect of 5-Fluorouracil Combined with Allicin against Lung and Colorectal Carcinoma Cells

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1947
Author(s):  
Adrian Bogdan Țigu ◽  
Vlad-Alexandru Toma ◽  
Augustin Cătălin Moț ◽  
Ancuța Jurj ◽  
Cristian Silviu Moldovan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Death ◽  
Colorectal Carcinoma ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Antitumor Effect ◽  
Single Agent ◽  
Carcinoma Cells ◽  
Lung Cancer Cells ◽  
Synergistic Antitumor Effect

5-fluorouracil (5-FU) is an anticancer drug used to inhibit the proliferation of many different tumor cells. Since severe events are associated with this compound, its combination with different anticancer drugs or adjuvants would allow the use of a significantly lower dose of 5-FU. In this study, we highlighted that the combination of allicin with 5-FU inhibited the cell migration and proliferation of colorectal and lung cancer cells. 5-FU inhibited cell growth with a similar inhibitory concentration for both normal and tumor cells (~200µM), while allicin showed different inhibitory concentrations. With an IC50 of 8.625 µM, lung cancer cells were the most sensitive to allicin. Compared to 5-FU and allicin single-agent treatments, the co-treatment showed a reduced viability rate, with p < 0.05. The morphological changes were visible on all three cell lines, indicating that the treatment inhibited the proliferation of both normal and tumor cells. We highlighted different cell death mechanisms—apoptosis for lung cancer and a non-apoptotic cell death for colorectal cancer. The synergistic antitumor effect of 5-FU combined with allicin was visible against lung and colorectal carcinoma cells. Better results were obtained when a lower concentration of 5-FU was combined with allicin than the single-agent treatment at IC50.

The Superior Antitumor Effect of Self-Assembled Paclitaxel Nanofilaments for Lung Cancer Cells

2018 ◽  
Vol 16 (2) ◽  
pp. 171-178
Author(s):  
Mengyu He ◽  
Jiali Zhu ◽  
Na Yu ◽  
Hui Kong ◽  
Xiaoning Zeng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Stress Proteins ◽  
A549 Cells ◽  
Lung Cancer Cells ◽  
Antitumor Effects ◽  
Self Assembled

Objectives: Paclitaxel (Ptx) has been regarded as one of the most effective chemotherapeutic drugs for lung cancers. Increasing studies focused on the nano-delivery system of Ptx due to its poor solubility and hypersensitivity. The aim of the recent study was to investigate the antitumor effects of self-assembled Ptx nano-filaments for lung cancer cells. </P><P> Methods: In the present study, we designed and synthesized novel Ptx-loaded nano-filaments through conjugation of Ptx and succinic acid (SA) (Ptx-SA, P-NFs). Non-small cell lung cancer (NSCLC) A549 and H460 cells were used for detecting the antitumor effects of P-NFs, including cytotoxicity, apoptosis, and migration. Western blotting was performed for analyzing mechanism. Results: P-NFs nano-filaments exerted superior antitumor effects against NSCLC cells compared with free Ptx using cytotoxicity tests. Furthermore, P-NFs nano-filaments were much more effective in inducing NSCLC cells apoptosis and inhibiting A549 cells migration than free Ptx. To elucidate the underlying mechanisms, the expression of apoptotic and endoplasmic reticulum (ER) stress proteins was detected. The results indicated that P-NFs nano-filaments enhanced the expression of bax/bcl-2, protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1&#945; (IRE1&#945;), phospho- c-Jun N-terminal kinase (p-JNK), and C/EPB homologous protein (CHOP), which suggested that the strong antitumor effect of P-NFs nano-filaments may be partially attributed to the activation ER stress. The current work demonstrated that P-NFs nano-filaments showed superior cytotoxicity of lung cancer cells, highlighting a novel profile of nano-filaments delivery systems as potential strategies for facilitating the therapeutic efficacy of Ptx in lung cancer treatment.

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