scholarly journals Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Zhengyu Zha ◽  
Xiao-Ran Han ◽  
Matthew D Smith ◽  
Qun-Ying Lei ◽  
Kun-Liang Guan ◽  
...  
Keyword(s):  
C825t Polymorphism

C825T polymorphism in the G protein β3-Subunit gene is associated with seasonal affective disorder

2003 ◽  
Vol 54 (7) ◽  
pp. 682-686 ◽  
Author(s):  
Matthäus Willeit ◽  
Nicole Praschak-Rieder ◽  
Peter Zill ◽  
Alexander Neumeister ◽  
Manfred Ackenheil ◽  
...  
Keyword(s):  
Affective Disorder ◽  
G Protein ◽  
Seasonal Affective Disorder ◽  
Subunit Gene ◽  
C825t Polymorphism

scholarly journals Worldwide Ethnic Distribution of the G Protein β3 Subunit 825T Allele and Its Association with Obesity in Caucasian, Chinese, and Black African Individuals

1999 ◽  
Vol 10 (9) ◽  
pp. 1921-1930
Author(s):  
WINFRIED SIFFERT ◽  
PETER FORSTER ◽  
KARL-HEINZ JÖCKEL ◽  
DAVID A. MVERE ◽  
BERND BRINKMANN ◽  
...  
Keyword(s):  
G Protein ◽  
Young Male ◽  
Normal Weight ◽  
Allele Frequencies ◽  
Gene Encoding ◽  
Black Africans ◽  
Black African ◽  
South Africans ◽  
825T Allele ◽  
C825t Polymorphism

Abstract. Recently, it was demonstrated that one allele (825T) of the gene encoding the G protein β3 subunit (GNB3) is associated with hypertension in Germans. This study investigates a possible association with obesity in young male Germans, Chinese, and black South Africans with low, intermediate, and high 825T allele frequencies, respectively. In each of these three distinct cohorts, the 825T allele frequency was increased significantly in overweight (body mass index [BMI] ≥25 kg/m2) and obese individuals (BMI >27 kg/m2) compared to those with normal weight. The 825T allele frequencies in these three BMI groups were, respectively, 29.5, 39.3, and 47.7% in Germans, 46.8, 53.9, and 58.6% in Chinese, and 83.1, 87.7, and 90.9% in South Africans. In each of these three distinct groups, the 825T allele was significantly associated with obesity with odds ratios between 2 and 3. More urban than rural black Africans were overweight despite similar 825T allele frequencies in both populations, which underscores the role of both genetic and environmental factors. BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity. Genotyping of 5254 individuals from 55 native population samples from Africa, the Americas, Europe, Asia, Australia, and New Guinea demonstrated highest 825T allele frequencies in black Africans (82%) and intermediate values in east Asians (47%). It is anticipated that high frequencies of the 825T allele in Africans and Asians may contribute to an obesity and hypertension epidemic if Westernization of lifestyles continues.

scholarly journals C825T Polymorphism of the G Protein β 3 -Subunit and Antihypertensive Response to a Thiazide Diuretic

Hypertension ◽  
2001 ◽  
Vol 37 (2) ◽  
pp. 739-743 ◽  
Author(s):  
Stephen T. Turner ◽  
Gary L. Schwartz ◽  
Arlene B. Chapman ◽  
Eric Boerwinkle
Keyword(s):  
G Protein ◽  
Thiazide Diuretic ◽  
C825t Polymorphism ◽  
Antihypertensive Response

scholarly journals The role of G protein gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation

Retrovirology ◽  
2012 ◽  
Vol 9 (1) ◽  
pp. 1 ◽  
Author(s):  
Jennifer Juno ◽  
Jeffrey Tuff ◽  
Robert Choi ◽  
Catherine Card ◽  
Joshua Kimani ◽  
...  
Keyword(s):  
G Protein ◽  
Immune Activation ◽  
Protein Gene ◽  
C825t Polymorphism ◽  
Gnb3 C825t ◽  
Hiv 1

[623] THE GNB3 C825T POLYMORPHISM AFFECTS RESPONSE TO HCV THERAPY WITH PEGYLATED INTERFERON IN HCV/HIV CO-INFECTED BUT NOT IN HCV MONO-INFECTED PATIENTS

2007 ◽  
Vol 46 ◽  
pp. S235-S236
Author(s):  
J. Nattermann ◽  
K. Bueren ◽  
HD. Nischalke ◽  
G. Ahlenstiel ◽  
T. Berg ◽  
...  
Keyword(s):  
Pegylated Interferon ◽  
Hcv Therapy ◽  
C825t Polymorphism ◽  
Gnb3 C825t

Association of GNB3 gene C825T polymorphism with coronary heart disease

2007 ◽  
Vol 43 (8) ◽  
pp. 937-941
Author(s):  
A. G. Nikitin ◽  
D. A. Chudakova ◽  
E. V. Spitsina ◽  
L. O. Minushkina ◽  
D. A. Zateishchikov ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
C825t Polymorphism
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