scholarly journals Neuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival

2017 ◽  
Vol 8 (3) ◽  
pp. e2635-e2635 ◽  
Author(s):  
Theresa M Thole ◽  
Marco Lodrini ◽  
Johannes Fabian ◽  
Jasmin Wuenschel ◽  
Sebastian Pfeil ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Neuroblastoma Cells ◽  
Mitotic Cell ◽  
Mitotic Cell Cycle ◽  
Cycle Progression

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

2010 ◽  
Vol 12 (5) ◽  
pp. 447-456 ◽  
Author(s):  
Isabel Novoa ◽  
Javier Gallego ◽  
Pedro G. Ferreira ◽  
Raul Mendez
Keyword(s):  
Cell Cycle ◽  
Translational Control ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Mitotic Cell Cycle ◽  
Cycle Progression

scholarly journals XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE

2016 ◽  
Vol 7 (10) ◽  
pp. e2409-e2409 ◽  
Author(s):  
Shuai Hou ◽  
Na Li ◽  
Qian Zhang ◽  
Hui Li ◽  
Xinyue Wei ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Transcriptional Regulation ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Mitotic Cell Cycle ◽  
Cycle Progression

Natural sourced inhibitors of EGFR, PDGFR, FGFR and VEGFR-mediated signaling pathways as potential anticancer agents

2021 ◽  
Vol 28 ◽  
Author(s):  
Sisir Nandi ◽  
Rishita Dey ◽  
Asmita Samadder ◽  
Aaruni Saxena ◽  
Anil Kumar Saxena
Keyword(s):  
Cell Cycle ◽  
Cancer Progression ◽  
Anticancer Agents ◽  
Cell Cycle Progression ◽  
Molecular Mechanisms ◽  
Mitotic Cell ◽  
Cell Cycle Checkpoints ◽  
Signalling Pathways ◽  
Mitotic Cell Cycle ◽  
Cycle Progression

: The molecular mechanisms of mitotic cell cycle progression involve very tightly restricted types of machinery which are highly regulated by a fine balance between the positive and negative accelerators (or regulators). These regulators include several checkpoints that have proteins acting as enzymes and their activating partners. These checkpoints incessantly monitor the external as well as internal environments such as growth signals, favorable conditions for growth, cell size, DNA integrity of the cell and hence function to maintain the highly ordered cell cycle progression by sustaining cell homeostasis and promotes error-free DNA replication and cell cycle, division. To progress through the mitotic cell cycle, the cell has to successfully drive past the cell cycle checkpoints. Due to the abnormal behavior of some cell cycle proteins, the cells tend to divide continuously overcoming the tight regulation of cell cycle checkpoints. Such anomalies may lead to unwanted cell division and this deregulation of cell cycle events is considered as one of the main reasons behind tumor development and thus cancer progression. So the understanding of the molecular mechanisms in cancer progression might be insightful for designing several cancer treatment strategies. The deregulation in the checkpoints is caused due to the changes brought in the tyrosine residues of TPKs via PDGFR, EGFR, FGFR, and VEGFR-mediated signalling pathways. Therefore, the inhibitors of PDGFR, EGFR, FGFR, and VEGFR-mediated signalling pathways would be potential anticancer agents. The resistance and toxicity in the existing synthetic anticancer chemotherapeutics may decrease the life span of a patient. For a long, natural products have always played an essential alternative source of therapeutic agents due to having the least or no side effect and toxicity. The present study is an attempt to promote the natural anticancer drug development focusing on the updated structural information of PDGFR, EGFR, FGFR, and VEGFR inhibitors isolated from the plant sources. The data used in this review has been collected from internet resources viz. GOOGLE Web, GOOGLE SCHOLAR, and PubMed Central. The citation of each report was first checked after which the articles were selected as an authentic reference for the present study. Around 200 journal articles were selected of which around 142 were selected finally for presenting the study on the natural sourced inhibitors of EGFR, PDGFR, FGFR, and VEGFR-mediated signaling pathways which would help in the potential cancer treatment.

scholarly journals The Exon Junction Complex Controls the Efficient and Faithful Splicing of a Subset of Transcripts Involved in Mitotic Cell-Cycle Progression

2016 ◽  
Vol 17 (8) ◽  
pp. 1153 ◽  
Author(s):  
Kazuhiro Fukumura ◽  
Shunichi Wakabayashi ◽  
Naoyuki Kataoka ◽  
Hiroshi Sakamoto ◽  
Yutaka Suzuki ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Exon Junction Complex ◽  
Mitotic Cell Cycle ◽  
Cycle Progression ◽  
Exon Junction

The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression

Gene ◽  
2001 ◽  
Vol 266 (1-2) ◽  
pp. 103-110 ◽  
Author(s):  
Rachel J West ◽  
Andrew Y Sun ◽  
Diane L Church ◽  
Eric J Lambie
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Mitotic Cell ◽  
Cation Channel ◽  
Mitotic Cell Cycle ◽  
Cycle Progression ◽  
Channel Protein ◽  
C Elegans
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