scholarly journals Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer

2017 ◽  
Vol 8 (9) ◽  
pp. e3049-e3049 ◽  
Author(s):  
Jian Gao ◽  
Minmin Fan ◽  
Shuang Peng ◽  
Minxia Zhang ◽  
Gang Xiang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Small Molecule ◽  
Triple Negative Breast Cancer ◽  
Therapeutic Strategy ◽  
Triple Negative ◽  
Autophagic Cell Death

Abstract LB-A16: Novel Small Molecule ONC201 Induces Cell Death in Triple Negative and Non-triple Negative Breast Cancer Cells

2015 ◽  
Author(s):  
Marie D. Baumeister ◽  
Jessica Wagner ◽  
Christina L.B. Kline ◽  
Joshua E. Allen ◽  
David T. Dicker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Small Molecule ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative

Abstract P5-05-12: Small molecule targeting regulated cell death pathways in treating triple negative breast cancer

2020 ◽  
Author(s):  
Venkata Mahidhar Yenugonda ◽  
Ariana Waters ◽  
Sivaramakrishna Yadavalli ◽  
Diego Marzese ◽  
Surojeet Senugupta ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Small Molecule ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Cell Death Pathways ◽  
Regulated Cell Death

New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms

2020 ◽  
Vol 20 ◽  
Author(s):  
Milad Ashrafizadeh ◽  
Reza Mohammadinejad ◽  
Shima Tavakol ◽  
Zahra Ahmadi ◽  
Amihossein Sahebkar
Keyword(s):  
Breast Cancer ◽  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Er Stress ◽  
Tumor Cells ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Mortality ◽  
Autophagic Cell Death ◽  
Cancer Pathology

Background: Breast cancer is accounted as the fifth leading cause of mortality among the other cancers. Notwithstanding, Triple Negative Breast Cancer (TNBC) is responsible for the 15-20% of breast cancer mortality. Despite the many investigations, it remains incurable in part due to insufficient understanding of its exact mechanisms. Methods: A literature search was performed in PubMed, SCOPUS and Web of Science databases using the keywords autophagy, Endoplasmic Reticulum (ER) stress, apoptosis, TNBC and the combinations of these keywords. Results: It was found that autophagy plays a dual role in cancer, so that it may decrease the viability of tumor cells or act as a cytoprotective mechanism. It then appears that using compounds having modulatory effects on autophagy is of importance in terms of induction of autophagic cell death and diminishing the proliferation and metastasis of tumor cells. Also, ER stress can be modulated in order to stimulate apoptotic and autophagic cell death in tumor cells. Conclusion: Perturbation in the signaling pathways related to cell survival leads to the initiation and progression of cancer. Regarding the advancement in the cancer pathology, it seems that modulation of autophagy and ER stress are promising.

scholarly journals Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo

2017 ◽  
Vol 8 (4) ◽  
pp. 2687-2701 ◽  
Author(s):  
Lan Zhang ◽  
Leilei Fu ◽  
Shouyue Zhang ◽  
Jin Zhang ◽  
Yuqian Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Small Molecule ◽  
Triple Negative Breast Cancer ◽  
Triple Negative

ULK1 is identified as a target in TNBC; thus a small-molecule agonist is discovered by targeting ULK1-modulated cell death, associated with autophagy and apoptosis.

scholarly journals Fluoxetine induces autophagic cell death via eEF2K-AMPK-mTOR-ULK complex axis in triple negative breast cancer

2017 ◽  
Vol 51 (2) ◽  
pp. e12402 ◽  
Author(s):  
Dejuan Sun ◽  
Lingjuan Zhu ◽  
Yuqian Zhao ◽  
Yingnan Jiang ◽  
Lixia Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Autophagic Cell Death
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