Oocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice

Background: Infertility is defined as the inability to conceive after at least one year of unprotected intercourse. It is a complex disorder with significant medical, psychosocial, and economic problems. In about one third of couples are infertile. Approximately 167 million married women aged 15-49 years in developing countries were infertility. The present study aimed to determine the most common causes of female infertility in patients who visiting the National Ayuvedic Teaching Hospital, Borella, Sri Lanka. Methods: In this study 635 infertile (primary and secondary) women were selected to determine the causes of infertility. The subjects were selected from the gynecology clinic, between the periods of February 2015 to March 2016. The data were gathered using a questionnaire; and after that proper statistical method was applied to analyze the data. Results: From the results age between 28-37 years (37.16%) are more prevalent to infertility and the causes of infertility are mainly due to anovulatory cycle (31.18%) and menstrual irregularities (19.21%). BMI also one of the significant cause for infertility. Conclusion: Therefore, identifying the risk factors and proper treatment on time along with policy makers providing facilities to resolve the infertility could possible diverse this alarming increasing trend of infertility.

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EVALUATION OF HYSTEROSALPINGOGRAPHY VERSUS LAPAROSCOPY IN THE DETERMINATION OF TUBAL FACTORS IN FEMALE INFERTILITY: A HOSPITAL BASED COMPARATIVE STUDY.

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i9.1421 ◽

2020 ◽

Vol 4 (9) ◽

Author(s):

Richa Choudhary ◽

Rishikant Sinha

Keyword(s):

Female Infertility ◽

Diagnostic Methods ◽

Panoramic View ◽

Tubal Patency ◽

Pelvic Organs ◽

Clinical Investigations ◽

Detailed Assessment ◽

Reproductive Anatomy ◽

Tubal Pathology

Objectives: Hysterosalpingography and laparoscopy both are the diagnostic methods for assessment of female infertility. The present study was to compare the evaluation of hysterosalpingography (HSG) versus laparoscopy in determination of tubal factors in female infertility. Methods: Detailed assessment, physical examination and clinical investigations were performed in all 100 infertile female with age 20 years to 40 years. All patients were advised to perform digital HSG. Patients with an abnormal HSG underwent laparoscopy without delay, whereas in patients with a normal HSG, laparoscopy was performed three months after HSG. HSG is best scheduled during the 2nd -5th day interval immediately following the end of menstruation, to minimize risk for infection, avoid interference from intrauterine blood and clot, and to prevent any possibility that the procedure might be performed after conception. Results: Data was analysed by using IBM SPSS version 23 software. All data was tabulated and percentages were calculated. Mean ± standard deviation was observed. Conclusions: Diagnostic laparoscopy is the gold standard in diagnosing tubal pathology and other intra-abdominal causes of infertility. Other hand, Hysterosalpingography is a frequently utilized diagnostic tool in the assessment of tubal status and detection of uterine anatomical defects in infertility. Hysterosalpingography and laparoscopy are not alternatives but complimentary investigations. But, inadequacy of hysterosalpingography (HSG) in determining the state of tubal patency, emphasizes the need for laparoscopy. Laparoscopy provides both a panoramic view of the pelvic reproductive anatomy and a magnified view of pelvic organs and peritoneal surfaces. Keywords: Female infertility, Tubal patency, HSG, Laparoscopy

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Islet Beta-Cell Specific Deletion of UBL5 Gene Associated with Mitochondrial Stress Leads to Diabetes in Mice and Beta-Cell Impairment/Death

Diabetes ◽

10.2337/db18-311-lb ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 311-LB

Author(s):

CHRISTIAN HARALAMBOUS ◽

VIKTORIA NTOUMA

Keyword(s):

Beta Cell ◽

Mitochondrial Stress ◽

Islet Beta Cell ◽

Diabetes In Mice ◽

Specific Deletion

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1921-P: Nonalcoholic Steatohepatitis in Mice with Hepatocyte-Specific Deletion of Mitochondrial Fission Factor

Diabetes ◽

10.2337/db20-1921-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1921-P

Author(s):

YUKINA TAKEICHI ◽

TAKASHI MIYAZAWA ◽

SHOHEI SAKAMOTO ◽

RYUICHI SAKAMOTO ◽

MASATOSHI NOMURA ◽

...

Keyword(s):

Nonalcoholic Steatohepatitis ◽

Mitochondrial Fission ◽

Specific Deletion

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