scholarly journals Cdc25A phosphatase: a key cell cycle protein that regulates neuron death in disease and development

2017 ◽  
Vol 8 (3) ◽  
pp. e2692-e2692 ◽  
Author(s):  
Subhas Chandra Biswas ◽  
Priyankar Sanphui ◽  
Nandini Chatterjee ◽  
Stav Kemeny ◽  
Lloyd A Greene
Keyword(s):  
Cell Cycle ◽  
Neuron Death ◽  
Cell Cycle Protein ◽  
Cdc25a Phosphatase

scholarly journals Cell-Cycle Protein Expression in a Population-Based Study of Ovarian and Endometrial Cancers

2015 ◽  
Vol 5 ◽  
Author(s):  
Ashley S. Felix ◽  
Mark E. Sherman ◽  
Stephen M. Hewitt ◽  
Munira Z. Gunja ◽  
Hannah P. Yang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Expression ◽  
Population Based ◽  
Cell Cycle Protein ◽  
Population Based Study ◽  
Endometrial Cancers

scholarly journals The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

2019 ◽  
Vol 294 (32) ◽  
pp. 12099-12111 ◽  
Author(s):  
Jennifer L. McCann ◽  
Madeline M. Klein ◽  
Evelyn M. Leland ◽  
Emily K. Law ◽  
William L. Brown ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cyclin D1 ◽  
Nuclear Import ◽  
Cell Cycle Protein

scholarly journals IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

Diabetologia ◽  
2008 ◽  
Vol 51 (10) ◽  
pp. 1862-1872 ◽  
Author(s):  
J. Agudo ◽  
E. Ayuso ◽  
V. Jimenez ◽  
A. Salavert ◽  
A. Casellas ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Beta Cell ◽  
Endocrine Pancreas ◽  
Cell Replication ◽  
Cell Cycle Protein ◽  
Beta Cell Replication ◽  
Igf I

Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children

2001 ◽  
Vol 103 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Carlos G. Carlotti ◽  
Bodour Salhia ◽  
Sheila Weitzman ◽  
Mark Greenberg ◽  
Peter B. Dirks ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Expression ◽  
Choroid Plexus ◽  
Proliferative Index ◽  
Cell Cycle Protein ◽  
Choroid Plexus Tumors

B Cell Receptor (BCR) Ligation Enhances Cell Survival in Progressive Chronic Lymphocytic Leukemia (CLL).

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 966-966
Author(s):  
Pierre-Antoine Deglesne ◽  
Natalie Chevallier ◽  
Remi Letestu ◽  
Celia Salanoubat ◽  
Laurence Sanhes ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Survival ◽  
Disease Progression ◽  
Mtt Assay ◽  
Specific Antibody ◽  
Progressive Disease ◽  
Lymphocytic Leukemia ◽  
Gene Profiling ◽  
Cell Cycle Protein ◽  
Promoting Effect

Abstract Recent gene profiling studies demonstrated that signalisation through the BCR plays a central role during CLL disease progression. However, incidence of BCR engagement on cell survival remains unclear as both increased and decreased apoptosis have been reported after BCR ligation by anti-mu antibodies. We investigated the effect of anti-mu exposure on fresh cells from 32 untreated CLL cases. Cell viability was assessed both by MTT assay and Annexin V/ IP labelling. Culture conditions were set after time and dose experiments. A 25% increase of viability, obtained by MTT assay after 72h of culture, was considered as significant. When a coated rabbit anti-human IgH mu specific antibody was used, it significantly prevented apoptosis in 20/32 cases (named responders) and never increased it. On the same CLL cases, soluble goat F(ab’)2 anti-human IgH mu specific antibody increased apoptosis in all but one case. However, coating of this latter antibody to the culture plate cancelled the pro-apoptotic effect and restored cell survival promoting effect in 13/14 cases tested. Unspecific effects were ruled out using control antibodies. Cytometry experiments and confocal microscopy demonstrated that uncoated antibody was rapidly internalized and degraded. In responders cases, enhanced survival was supported by increased expression of early cell cycle protein cyclin D2 and cdk4. There was no subsequent cell cycle progression as shown by IP staining and absence of pRB phosphorylation most likely related to the lack of p27 down regulation. There was a strong correlation between the extent of apoptosis prevention after anti-mu exposure and disease progression. Indeed, the 12 over 32 cases who were found to have no IgVH somatic hypermutations, happened to be all responders. Conversely among the 20 mutated cases, 12/20 were non responders and had a clinically stable disease. As for the 8 responders with somatic mutations, four had detectable levels of ZAP 70 protein and 2 others had a clinically progressive disease. In conclusion, coated anti-mu antibody is likely to mimic in vivo conditions of stimulation, suggesting that BCR ligation could play a major role in the pathophysiology of the progressive disease, giving a survival advantage to these CLL cells

scholarly journals Effect of simvastatin on proliferative nephritis and cell-cycle protein expression

1999 ◽  
Vol 56 ◽  
pp. S84-S87 ◽  
Author(s):  
Ashio Yoshimura ◽  
Takashi Nemoto ◽  
Youichi Sugenoya ◽  
Kiyoko Inui ◽  
Susumu Watanabe ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Protein Expression ◽  
Cell Cycle Protein
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