scholarly journals Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

2017 ◽  
Vol 8 (2) ◽  
pp. e2585-e2585 ◽  
Author(s):  
Yuning Liao ◽  
Ningning Liu ◽  
Xianliang Hua ◽  
Jianyu Cai ◽  
Xiaohong Xia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Proliferation ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

The ubiquitin-specific protease USP10 modulates androgen receptor function

2005 ◽  
Vol 245 (1-2) ◽  
pp. 138-146 ◽  
Author(s):  
Hortensia Faus ◽  
Hellmuth-Alexander Meyer ◽  
Martina Huber ◽  
Inke Bahr ◽  
Bernard Haendler
Keyword(s):  
Androgen Receptor ◽  
Receptor Function ◽  
Specific Protease ◽  
Ubiquitin Specific Protease ◽  
Androgen Receptor Function

scholarly journals Induction of the SUMO-specific Protease 1 Transcription by the Androgen Receptor in Prostate Cancer Cells

2007 ◽  
Vol 282 (52) ◽  
pp. 37341-37349 ◽  
Author(s):  
Tasneem Bawa-Khalfe ◽  
Jinke Cheng ◽  
Zhengxin Wang ◽  
Edward T. H. Yeh
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Specific Protease

scholarly journals Huaier Extract Inhibits Prostate Cancer Growth via Targeting AR/AR-V7 Pathway

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhengfang Liu ◽  
Cheng Liu ◽  
Keqiang Yan ◽  
Jikai Liu ◽  
Zhiqing Fang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Nuclear Translocation ◽  
Mrna Levels ◽  
Castration Resistant Prostate Cancer ◽  
Castration Resistant ◽  
Specific Protease ◽  
Hormone Sensitive

The androgen receptor (AR) plays a pivotal role in prostatic carcinogenesis, and it also affects the transition from hormone sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC). Particularly, the persistent activation of the androgen receptor and the appearance of androgen receptor splicing variant 7 (AR-V7), could partly explain the failure of androgen deprivation therapy (ADT). In the present study, we reported that huaier extract, derived from officinal fungi, has potent antiproliferative effects in both HSPC and CRPC cells. Mechanistically, huaier extract downregulated both full length AR (AR-FL) and AR-V7 mRNA levels via targeting the SET and MYND domain-containing protein 3 (SMYD3) signaling pathway. Huaier extract also enhanced proteasome-mediated protein degradation of AR-FL and AR-V7 by downregulating proteasome-associated deubiquitinase ubiquitin-specific protease 14 (USP14). Furthermore, huaier extract inhibited AR-FL/AR-V7 transcriptional activity and their nuclear translocation. More importantly, our data demonstrated that huaier extract could re-sensitize enzalutamide-resistant prostate cancer cells to enzalutamide treatment in vitro and in vivo models. Our work revealed that huaier extract could be effective for treatment of prostate cancer either as monotherapy or in combination with enzalutamide.

scholarly journals Stabilizing Androgen Receptor in Mitosis Inhibits Prostate Cancer Proliferation

Cell Cycle ◽  
2007 ◽  
Vol 6 (6) ◽  
pp. 647-651 ◽  
Author(s):  
Donald J. Vander Griend ◽  
Ivan V. Litvinov ◽  
John T. Isaacs
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Proliferation

scholarly journals Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†

2019 ◽  
Vol 100 (4) ◽  
pp. 1118-1128 ◽  
Author(s):  
Hong Tian ◽  
Yongwei Huo ◽  
Jie Zhang ◽  
Shangshu Ding ◽  
Zhiyong Wang ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Hormone Secretion ◽  
Male Reproduction ◽  
Seminiferous Tubules ◽  
Knockout Mouse Model ◽  
Male Subfertility ◽  
Testicular Cells ◽  
Different Ages ◽  
Specific Protease ◽  
Ubiquitin Specific Protease

Abstract Ubiquitin-specific protease 26 (USP26) is an X-linked gene exclusively expressed in the testis and codes for the USP26, a peptidase enzyme that belongs to the deubiquitinating enzyme family. Recent studies have indicated that mutations in USP26 affect spermatogenesis and are associated with male infertility in humans and mice. However, the exact role of USP26 in spermatogenesis and how it affects male reproduction remains unknown. In this study, we generated a conventional Usp26 knockout mouse model and found that deletion of Usp26 in male mice (Usp26−/Y) leads to significantly reduced pup numbers per litter and significantly increased intervals between two consecutive offspring. We also found that the serum follicle stimulating hormone and testosterone levels of adult Usp26−/Y mice were significantly decreased compared to those of Usp26+/Y mice. Histological examination results showed that Usp26−/Y mice had significantly increased percentage of abnormal seminiferous tubules at different ages. Flow cytometry results exhibited that Usp26−/Y mice had significantly reduced percentage of mature haploid cells in the testes compared to Usp26+/Y mice. Sperm counts in epididymis were also significantly declined in Usp26−/Y mice compared to those in Usp26+/Y mice. Immunohistochemistry and immunofluorescence staining and immunoprecipitation analysis results showed that USP26 and androgen receptor were co-localized in mouse testicular cells at different ages and they both had physiological interactions. All these results demonstrated that the loss of Usp26 affects spermatogenesis and hormone secretion and causes male subfertility. Our study also provides the evidence on the interactions between USP26 and androgen receptor in mouse testis, whereby pointing to a potential mechanism.

scholarly journals Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer

Oncotarget ◽  
2015 ◽  
Vol 6 (35) ◽  
pp. 37724-37736 ◽  
Author(s):  
Urszula L. McClurg ◽  
Victoria J. Harle ◽  
Arash Nabbi ◽  
Amanda Batalha-Pereira ◽  
Scott Walker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Therapeutic Targets ◽  
Specific Protease ◽  
Ubiquitin Specific Protease
Sign in / Sign up

Export Citation Format

Share Document